Unexpected Effects of a Heterozygous Dnmt1 Null Mutation on Age-Dependent DNA Hypomethylation and Autoimmunity

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

Clinical and Experimental Immunology

1966 • 1,544 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

DNA hypomethylation leads to elevated mutation rates

1998 • 935 citations

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1999 • 898 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Prognostic factors in lupus nephritis

1983 • 755 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

DNA methylation and chromatin modification

1999 • 641 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

Patterns of cytokine gene expression by CD4+ T cells from young and old mice.

1993 • 357 citations

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

1993 • 350 citations

DNA methylation is a reversible biological signal

1999 • 334 citations

Asymptotic Optimality of Fisher's Method of Combining Independent Tests

1971 • 246 citations

Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.

1995 • 209 citations

DNA Demethylation In Vitro: Involvement of RNA

1996 • 188 citations

The 5-Methylcytosine in DNA of Rats

1973 • 177 citations

The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.

1973 • 167 citations

MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery

2000 • 146 citations

Mechanisms of drug‐induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo

1997 • 117 citations

Formation of methylation patterns in the mammalian genome

1997 • 114 citations

Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2

2000 • 102 citations

Aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes.

1987 • 95 citations

Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice.

1989 • 95 citations

Quantitative changes in T cell DNA methylation occur during differentiation and ageing

1990 • 91 citations

DNA methylation and embryogenesis

1993 • 77 citations

Role of the ras-MAPK Signaling Pathway in the DNA Methyltransferase Response to DNA Hypomethylation

1998 • 76 citations

Biological Significance of DNA Methylation in the Ageing Process

1993 • 67 citations

Asymptotic Optimality of Fisher's Method of Combining Independent Tests

1971 • 56 citations

DNA methylation: regulation of gene expression and role in the immune system

1997 • 48 citations

Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity.

1997 • 45 citations

Endogenous virus genomes become hypomethylated tissue—Specifically during aging process of C57BL mice

1989 • 33 citations

Analysis of human peripheral blood T cells and single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome

1999 • 28 citations

Similarities in B cell repertoire development between autoimmune and aging normal mice.

1992 • 27 citations

Spontaneous occurrence of autoimmune cholangitis in senescent mice

1993 • 16 citations