Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

2000 • 783 citations

Branched-Chain Amino Acid Metabolism

1999 • 754 citations

Leucine. A possible regulator of protein turnover in muscle.

1975 • 746 citations

Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes

1995 • 654 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

Regulation of peptide‐chain elongation in mammalian cells

2002 • 467 citations

Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?

1982 • 445 citations

Signaling Pathways Involved in Translational Control of Protein Synthesis in Skeletal Muscle by Leucine

2001 • 428 citations

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

2001 • 388 citations

Regulation of mammalian translation factors by nutrients

2002 • 388 citations

A molecular model of human branched-chain amino acid metabolism

1998 • 386 citations

Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6

1999 • 356 citations

Mechanism of action of the immunosuppressant rapamycin

1995 • 334 citations

Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation

2001 • 296 citations

Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise

2002 • 289 citations

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

2002 • 243 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic β-Cells

2001 • 205 citations

Amino Acid-dependent Control of p70s6k

1999 • 205 citations

Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise

1998 • 204 citations

mTOR inhibitors: An overview

2001 • 193 citations

The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity

2001 • 180 citations

Regulation of branched-chain α-ketoacid dehydrogenase kinase

1984 • 175 citations

Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue

2002 • 173 citations

Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes

2000 • 164 citations

Control of p70 ribosomal protein S6 kinase and acetyl‐CoA carboxylase by AMP‐activated protein kinase and protein phosphatases in isolated hepatocytes

2002 • 162 citations

Role of Leucine in the Regulation of mTOR by Amino Acids: Revelations from Structure–Activity Studies

2001 • 157 citations

Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats

2002 • 135 citations

Metabolic and Autocrine Regulation of the Mammalian Target of Rapamycin by Pancreatic β-Cells

2002 • 131 citations

Control of protein synthesis by amino acid availability

2002 • 130 citations

Amino acids stimulate phosphorylation of p70 ^S6k and organization of rat adipocytes into multicellular clusters

1998 • 130 citations

Regulation of Translation Initiation by Amino Acids in Eukaryotic Cells

2001 • 104 citations

Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes

2003 • 102 citations

Purification and properties of branched-chain alpha-keto acid dehydrogenase phosphatase from bovine kidney.

1984 • 100 citations

Control of Translation by the Target of Rapamycin Proteins

2001 • 99 citations

Activity state of the branched chain α-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats

1983 • 99 citations

Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes

2002 • 96 citations

Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats

1977 • 96 citations

Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina

2001 • 88 citations

Subcellular Distribution of Branched-Chain Aminotransferase Activity in Rat Tissues

1988 • 81 citations

Regulation of branched-chain α-ketoacid dehydrogenase complex by covalent modification

1986 • 75 citations

Physiological covalent regulation of rat liver branched-chain α-ketoacid dehydrogenase

1985 • 74 citations

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes

2000 • 74 citations

Phosphorylation sites and inactivation of branched-chain α-ketoacid dehydrogenase isolated from rat heart, bovine kidney, and rabbit liver, kidney, heart, brain, and skeletal muscle

1986 • 72 citations

Amino Acid Regulation of Gene Expression

2001 • 62 citations

Effects of dietary protein intake on branched-chain keto acid dehydrogenase activity of the rat. Immunochemical analysis of the enzyme complex.

1988 • 59 citations

Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.

1989 • 58 citations

Branched-chain alpha-keto acid dehydrogenase complex in rat skeletal muscle: regulation of the activity and gene expression by nutrition and physical exercise.

1995 • 57 citations

Site-directed mutagenesis of phosphorylation sites of the branched chain alpha-ketoacid dehydrogenase complex

1994 • 53 citations

Dietary Control and Tissue Specific Expression of Branched-Chain α-Ketoacid Dehydrogenase Kinase

1995 • 51 citations

Interplay between insulin and nutrients in the regulation of translation factors

2001 • 49 citations

L-Leucine activates branched chain alpha-keto acid dehydrogenase in rat adipose tissue.

1981 • 44 citations

Effect of Dietary Protein on the Liver Content and Subunit Composition of the Branched-Chain α-Ketoacid Dehydrogenase Complex

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Purification of branched chain α-ketoacid dehydrogenase complex from rat liver

1987 • 30 citations

mTOR-Dependent Control of Skeletal Muscle Protein Synthesis

2001 • 29 citations

Insulin Signaling and the Control of PHAS-I Phosphorylation

2001 • 26 citations

Insulin regulation of the activity and phosphorylation of branched-chain 2-oxo acid dehydrogenase in adipose tissue

1989 • 23 citations

Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase

1992 • 19 citations

Regulation of Rat Liver Branched-Chain α-Keto Acid Dehydrogenase Activity by Meal Frequency and Dietary Protein

1990 • 15 citations

Nutritional and Hormonal Regulation of the Activity State of Hepatic Branched‐Chain α‐Keto Acid Dehydrogenase Complex^a

1989 • 14 citations

Controlled Overexpression of BCKD Kinase Expression: Metabolic Engineering Applied to BCAA Metabolism in a Mammalian System

2000 • 13 citations

Nutritional control of branched chain alpha-ketoacid dehydrogenase in rat hepatocytes.

1985 • 9 citations

Transamination and oxidation of leucine and valine in rat adipose tissue.

1988 • 7 citations