Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes

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1994 • 12,975 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis

1964 • 1,401 citations

Leptin

2000 • 1,368 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes*

1998 • 416 citations

The TOR Kinases Link Nutrient Sensing to Cell Growth

2001 • 348 citations

Mechanisms of Subcellular mRNA Localization

2002 • 326 citations

Cloning and Characterization of a Novel Insulin-regulated Membrane Aminopeptidase from Glut4 Vesicles

1995 • 320 citations

Insulin Stimulates Both Leptin Secretion and Production by Rat White Adipose Tissue

1997 • 276 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.

1999 • 203 citations

Human Placental Leucine Aminopeptidase/Oxytocinase

1996 • 191 citations

Role of Leucine in the Regulation of mTOR by Amino Acids: Revelations from Structure–Activity Studies

2001 • 157 citations

Amino acid effects on translational repressor 4E-BP1 are mediated primarily by<scp>l</scp>-leucine in isolated adipocytes

1998 • 150 citations

Diet‐ and diabetes‐induced changes of ob gene expression in rat adipose tissue

1995 • 141 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

Amino acids stimulate phosphorylation of p70 ^S6k and organization of rat adipocytes into multicellular clusters

1998 • 130 citations

The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity.

1994 • 127 citations

Compartmentalization of protein traffic in insulin-sensitive cells

1996 • 108 citations

Adipocytes Exhibit Abnormal Subcellular Distribution and Translocation of Vesicles Containing Glucose Transporter 4 and Insulin-Regulated Aminopeptidase in Type 2 Diabetes Mellitus: Implications Regarding Defects in Vesicle Trafficking

2001 • 102 citations

Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway

2000 • 87 citations

Regulation of the GLUT4/muscle-fat glucose transporter mRNA in adipose tissue of insulin-deficient diabetic rats.

1993 • 76 citations

Isolation and Characterization of the Two Major Intracellular Glut4 Storage Compartments

2002 • 76 citations

Amino Acid Regulation of Gene Expression

2001 • 62 citations

Regulation of the leptin content of obese human adipose tissue

2001 • 48 citations

Identification and characterization of leptin-containing intracellular compartment in rat adipose cells

2000 • 46 citations

Lipoprotein Lipase and Leptin Are Accumulated in Different Secretory Compartments in Rat Adipocytes

2001 • 35 citations

Effect of Enteral versus Parenteral Nutrition on Leptin Gene Expression and Release into the Circulation

1997 • 29 citations

Stimulation of Leptin Release by Actinomycin D in Rat Adipocytes

1998 • 8 citations