Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Rapid analysis of amino acids using pre-column derivatization

1984 • 2,491 citations

Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

1975 • 932 citations

Immunogenic structure of the influenza virus hemagglutinin

1982 • 759 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

Adenylate cyclase assay.

1979 • 485 citations

Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.

1978 • 480 citations

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1977 • 409 citations

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

1986 • 380 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

1986 • 341 citations

Role of Adenosine 3′,5′-Monophosphate in the Effects of Insulin and Anti-insulin Serum on Liver Metabolism

1968 • 328 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Glucagon and the a Cell

1981 • 290 citations

Resolution of some components of adenylate cyclase necessary for catalytic activity.

1977 • 283 citations

Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles.

1984 • 279 citations

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.

1988 • 275 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

Cyclic Guanosine 3′,5′-Monophosphate in Mammalian Tissues and Urine

1969 • 212 citations

[45] ADP-ribosylation of membrane components by pertussis and cholera toxin

1985 • 209 citations

Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.

1985 • 205 citations

Angiotensin II and alpha-adrenergic agonists inhibit rat liver adenylate cyclase.

1981 • 183 citations

Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.

1985 • 175 citations

Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.

1977 • 175 citations

Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats☆

1974 • 163 citations

Hyperglycemia of Diabetic Rats Decreased by a Glucagon Receptor Antagonist

1982 • 162 citations

Streptozocin: a review of its pharmacology, efficacy, and toxicity.

1982 • 146 citations

The spontaneously diabetic Wistar rat. Metabolic and morphologic studies

1977 • 145 citations

Chromatographic resolution and immunologic identification of the alpha 40 and alpha 41 subunits of guanine nucleotide-binding regulatory proteins from bovine brain.

1988 • 144 citations

Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni).

1984 • 119 citations

Increased insulin binding by hepatic plasma membranes from diabetic rats: normalization by insulin therapy.

1977 • 115 citations

The hepatic angiotensin II receptor. II. Effect of guanine nucleotides and interaction with cyclic AMP production.

1982 • 111 citations

The hepatic angiotensin II receptor. I. Characterization of the membrane-binding site and correlation with physiological response in hepatocytes.

1982 • 92 citations

Binding and biologic activity of glucagon in liver cell membranes of chronically hyperglucagonemic rats.

1977 • 88 citations

Effect of islet-activating pertussis toxin on the binding characteristics of Ca2+-mobilizing hormones and on agonist activation of phosphorylase in hepatocytes.

1986 • 86 citations

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes

1985 • 84 citations

Decreased Glucagon Receptors in Diabetic Rat Hepatocytes

1978 • 81 citations

The discovery and development of the BB rat colony: An animal model of spontaneous diabetes mellitus

1983 • 77 citations

Effect of Fasting and Streptozotocin in the Obese-hyperglycemic (ob/ob) Mouse: Apparent Lack of a Direct Relationship Between Insulin Binding and Insulin Effects

1977 • 67 citations

Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.

1988 • 63 citations

[43] Assessment of effects of vasopressin, angtiotensin II, and glucagon on Ca2+fluxes and phosphorylase activity in liver

1985 • 56 citations

Antibody specific to the alpha subunit of the guanine nucleotide-binding regulatory protein Go: developmental appearance and immunocytochemical localization in brain.

1988 • 50 citations

Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.

1984 • 45 citations

Production and characterization of monoclonal antibodies with specificity for the S100 beta polypeptide of brain S100 fractions.

1984 • 42 citations

α‐Subunits of N_s are released from the plasma membrane following cholera toxin activation

1986 • 41 citations

Effect of fasting and streptozotocin in the obese-hyperglycemic (ob/ob) mouse. Apparent lack of a direct relationship between insulin binding and insulin effects

1977 • 31 citations

Hepatic carbohydrate metabolism in the spontaneously diabetic Bio-Breeding Worcester rat

1981 • 20 citations

The effect of streptozotocin-induced diabetes on the early steps of glucagon action in isolated rat liver cells

1980 • 15 citations

Membrane Structural/Functional Properties of Adipocytes from Normal and Streptozotocin-diabetic Rats

1984 • 14 citations

A Decreased Response of Cyclic Adenosine Monophosphate Concentrations to Glucagon in Liver Slices from Streptozotocin-induced Diabetic Rats

1980 • 11 citations

Increased dose-response relationship of liver plasma membrane adenylate cyclase to glucagon stimulation in diabetic rats. A possible role of the guanyl nucleotide-binding regulatory protein

1982 • 9 citations

Changes in adenylate cyclase and 5′-nucleotidase activities in liver membranes from alloxan diabetic rats

1980 • 7 citations

Membrane structural/functional properties of adipocytes from normal and streptozotocin-diabetic rats

1984 • 4 citations

[Insulin, glucagon binding and adenylate cyclase activity of liver plasma membranes in streptozotocin-diabetic rats].

1978 • 2 citations