A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Guide for the Care and Use of Laboratory Animals

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Nonparametric Statistical Methods

1999 • 6,387 citations

A Multiple Comparison Procedure for Comparing Several Treatments with a Control

1955 • 5,730 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

ras GENES

1987 • 3,818 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Multiple Comparison Procedures

1987 • 2,256 citations

Multiple Comparison Procedures

2013 • 2,209 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

The multistep nature of cancer

1993 • 1,872 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Data Analysis and Regression: A Second Course in Statistics

1977 • 1,577 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Resampling-Based Multiple Testing.

1994 • 941 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

1995 • 393 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS

1997 • 329 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956.

1995 • 241 citations

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

1995 • 226 citations

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

1990 • 222 citations

Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity

1995 • 220 citations

Farnesyltransferase Inhibition Causes Morphological Reversion of ras-Transformed Cells by a Complex Mechanism That Involves Regulation of the Actin Cytoskeleton

1994 • 197 citations

Cancer therapy and p53

1995 • 194 citations

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.

1997 • 184 citations

To pop or not to pop: p53 as a critical modulator of tumour responsiveness to therapy in vivo?

1995 • 168 citations

The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.

1996 • 150 citations

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

1994 • 142 citations

Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2.

1996 • 127 citations

Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability

1993 • 124 citations

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.

1994 • 113 citations

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

1994 • 109 citations

PxF, a prenylated protein of peroxisomes.

1994 • 107 citations

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1995 • 99 citations

E2F-1 Cooperates with Topoisomerase II Inhibition and DNA Damage To Selectively Augment p53-Independent Apoptosis

1997 • 96 citations

Activated H-ras Rescues E1A-Induced Apoptosis and Cooperates with E1A To Overcome p53-Dependent Growth Arrest

1995 • 94 citations

Increased Tumor Proliferation and Genomic Instability without Decreased Apoptosis in MMTV-ras Mice Deficient in p53

1997 • 93 citations

The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis

1996 • 68 citations

Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis.

1997 • 64 citations

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1995 • 48 citations

Constitutive expression of the c-H-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line

1995 • 46 citations

Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors.

1997 • 36 citations

Chemotherapy of mammary carcinomas arising in ras transgenic mice

1993 • 22 citations