The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

The basics of basal transcription by RNA polymerase II

1994 • 409 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

The Ras signal transduction pathway

1994 • 345 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

Protein prenylation: more than just glue?

1992 • 208 citations

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

1994 • 185 citations

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

1992 • 180 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

Inhibition of cell growth by lovastatin is independent of ras function.

1991 • 130 citations

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.

1993 • 112 citations

[24] Biological assays for cellular transformation

1994 • 95 citations

Pathways of Ras Function: Connections to the Actin Cytoskeleton

1993 • 64 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 39 citations