DNA methylation is a reversible biological signal

DNA Methylation and Gene Function

1980 • 2,069 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

1996 • 428 citations

Role of DNA methylation in the regulation of transcription

1994 • 318 citations

DNA methylation patterns Formation and function

1984 • 312 citations

Loss of methylation activates Xist in somatic but not in embryonic cells.

1995 • 300 citations

Clonal inheritance of the pattern of DNA methylation in mouse cells.

1982 • 229 citations

Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells

1995 • 211 citations

Parental imprinting of autosomal mammalian genes

1994 • 208 citations

DNA Demethylation In Vitro: Involvement of RNA

1996 • 188 citations

DNA methylation: A molecular lock

1997 • 179 citations

Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation.

1986 • 175 citations

PARENTAL IMPRINTING AND HUMAN DISEASE

1996 • 170 citations

Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo.

1993 • 138 citations

Mechanisms of DNA Demethylation in Chicken Embryos

1995 • 129 citations

Dynamics of DNA methylation during development

1993 • 125 citations

DNA methylation properties: consequences for pharmacology

1994 • 105 citations

Enzymological characterization of DNA polymerase alpha. Basic catalytic properties processivity, and gap utilization of the homogeneous enzyme from human KB cells.

1979 • 105 citations

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

1990 • 76 citations

Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterization.

1991 • 71 citations

Enzymic removal of 5-methylcytosine from DNA by a human DNA-glycosylase

1993 • 69 citations

Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA

1997 • 60 citations

Ras Induces a General DNA Demethylation Activity in Mouse Embryonal P19 Cells

1995 • 58 citations

DNA methylation patterns: an additional level of information?

1991 • 49 citations

Methylation patterns of the human apoA-I/C-III/A-IV gene cluster in adult and embryonic tissues suggest dynamic changes in methylation during development.

1991 • 45 citations

Nucleic acids from self-assembly to induced-fit recognition

1997 • 28 citations

Regulated expression of muscle-specific genes introduced into mouse embryonal stem cells: inverse correlation with DNA methylation

1989 • 17 citations

A DNA Signal from the Thy-1 Gene Defines De Novo Methylation Patterns in Embryonic Stem Cells

1990 • 13 citations