The role of T-cell receptor dimerization in T-cell activation

Functional rafts in cell membranes

1997 • 9,471 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

NEUTRALIZING ANTIVIRAL B CELL RESPONSES

1997 • 467 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

T cell antigen receptor signal transduction

1997 • 390 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Molecular determinants of immunogenicity: the immunon model of immune response.

1976 • 366 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

1994 • 233 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

1999 • 226 citations

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

1992 • 221 citations

The influence of virus structure on antibody responses and virus serotype formation

1996 • 205 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Crystal Structure of the V _α Domain of a T Cell Antigen Receptor

1995 • 178 citations

Requirements for Peptide-induced T Cell Receptor Downregulation on Naive CD8+ T Cells

1997 • 169 citations

An Unusual Mechanism for Ligand Antagonism

1998 • 157 citations

αβ T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization

1997 • 147 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes

1998 • 118 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

Partial signaling by CD8+ T cells in response to antagonist ligands.

1996 • 111 citations

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

1995 • 106 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

1998 • 100 citations

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

1994 • 95 citations

Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution.

1994 • 88 citations

Two Distinct Pathways Exist for Down-Regulation of the TCR

1998 • 87 citations

Selective activation of the calcium signaling pathway by altered peptide ligands.

1996 • 83 citations

Zur Theorie der Reaktionsgeschwindigkeiten in Gasen

1919 • 78 citations

T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs

1999 • 73 citations

T cell positive selection by a high density, low affinity ligand

1998 • 69 citations

Antagonism of cytotoxic T lymphocyte‐mediated lysis by natural HIV‐1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides

1997 • 69 citations

Agonist‐induced T cell receptor down‐regulation: molecular requirements and dissociation from T cell activation

1997 • 66 citations

Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses

1994 • 62 citations

TCR ζ chain in T cell development and selection

1997 • 51 citations

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

1998 • 51 citations

Superactivation of an immune response triggered by oligomerized T cell epitopes

1997 • 50 citations

Altered Hapten Ligands Antagonize Trinitrophenyl-specific Cytotoxic T Cells and Block Internalization of Hapten-specific Receptors

1997 • 50 citations

Cutting Edge: A Test of the Dominant Negative Signal Model for TCR Antagonism

1999 • 46 citations

Formation of TCR dimers/trimers as a crucial step for T cell activation

1998 • 46 citations

A dominant-negative mutant of the Rab5 GTPase enhances T cell signaling by interfering with TCR down-modulation in transgenic mice.

1997 • 40 citations

Selective activation of CD8 T cell effector functions by epitope variants of lymphocytic choriomeningitis virus glycoprotein.

1996 • 27 citations

Four types of Ca²⁺ signals in naive CD8⁺ cytotoxic T cells after stimulation with T cell agonists, partial agonists and antagonists

1997 • 26 citations

Role of CD8 in Aberrant Function of Cytotoxic T Lymphocytes

1997 • 21 citations

T cell receptor α‐chain tail is required for protein kinase C‐mediated down‐regulation, but not for signaling

1997 • 20 citations

The role of T cell receptor dimerization for T cell antagonism and T cell specificity

1998 • 12 citations

Book-Review = Universes

1990 • 5 citations