Endothelin and endothelin receptor antagonists in systemic rheumatic disease

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Bosentan Therapy for Pulmonary Arterial Hypertension

2002 • 2,715 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

2001 • 1,521 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Pulmonary Hypertension

2006 • 917 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

Endothelins

1995 • 682 citations

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

1994 • 650 citations

Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells.

1993 • 576 citations

PATHOPHYSIOLOGY OF ENDOTHELIN IN THE CARDIOVASCULAR SYSTEM

1999 • 544 citations

Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

1990 • 446 citations

Pulmonary hypertension in the crest syndrome variant of systemic sclerosis

1986 • 377 citations

Growth regulatory properties of endothelins

1993 • 342 citations

Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation.

1991 • 340 citations

Pulmonary hypertension in systemic sclerosis: an analysis of 17 patients

1996 • 319 citations

Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats

1995 • 298 citations

Role of Endothelin in the Increased Vascular Tone of Patients With Essential Hypertension

1999 • 284 citations

Cloning and expression of human endothelin‐1 receptor cDNA

1991 • 282 citations

Pulmonary Hypertension in the CREST Syndrome Variant of Progressive Systemic Sclerosis (Scleroderma)

1977 • 274 citations

Prevalence and clinical correlates of pulmonary arterial hypertension in progressive systemic sclerosis

1983 • 272 citations

Clinical Efficacy of Sitaxsentan, an Endothelin-A Receptor Antagonist, in Patients With Pulmonary Arterial Hypertension

2002 • 243 citations

Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1

2001 • 241 citations

Circulating endothelin-1 levels in systemic sclerosis subsets--a marker of fibrosis or vascular dysfunction?

1994 • 240 citations

Pulmonary hypertension in systemic sclerosis: risk factors for progression and consequences for survival

2001 • 236 citations

Morphologic Changes in the Digital Arteries of Patients with Progressive Systemic Sclerosis (Scleroderma) and Raynaud Phenomenon

1980 • 236 citations

Endothelin, an endothelial‐dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action

1991 • 228 citations

Serum endothelin-1 concentrations and cold provocation in primary Raynaud's phenomenon

1990 • 216 citations

Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease.

1997 • 206 citations

Endothelins and the lung.

1996 • 196 citations

Oral iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis: A multicenter, placebo-controlled, double-blind study

1998 • 188 citations

Vasodilator Effects of Endothelin-Converting Enzyme Inhibition and Endothelin ET _A Receptor Blockade in Chronic Heart Failure Patients Treated With ACE Inhibitors

1996 • 180 citations

The pulmonary pathologic manifestations of the CREST syndrome

1990 • 178 citations

Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines.

1997 • 171 citations

Mortality in systemic sclerosis (scleroderma).

1992 • 169 citations

Significance of plasma endothelin-1 levels in patients with systemic sclerosis.

1992 • 158 citations

Pulmonary Hypertension

2000 • 142 citations

Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro.

1994 • 133 citations

Epidemiological study of patients with systemic sclerosis in Tokyo

1991 • 128 citations

Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats

1995 • 128 citations

Localization of endothelin-1 and its binding sites in scleroderma skin.

1994 • 120 citations

Signal Transduction Mechanisms Mediating the Vascular Actions of Endothelin

1997 • 118 citations

Endothelin Adrenocortical Secretagogue Effect Is Mediated by the B Receptor in Rats

1996 • 114 citations

A Cytokine Reborn?

2000 • 112 citations

Acute pro‐inflammatory actions of endothelin‐1 in the guinea‐pig lung: involvement of ET_A and ET_B receptors

1995 • 108 citations

HIGHLIGHTS ON ENDOTHELINS: A REVIEW

1997 • 108 citations

Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis

1995 • 104 citations

Endothelin_B receptor‐mediated contraction in human pulmonary resistance arteries

1996 • 102 citations

European multicentre study to define disease activity criteria for systemic sclerosis. I. Clinical and epidemiological features of 290 patients from 19 centres

2001 • 102 citations

Increased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis.

1994 • 100 citations

Comparison of the Effects of Selective Endothelin ETaand ETbReceptor Antagonists in Congestive Heart Failure

1997 • 92 citations

Rare diseases bullet 5: Primary pulmonary hypertension

1999 • 92 citations

Endothelin receptors in cultured adult rat cardiac fibroblasts

1993 • 90 citations

Expression of endothelin-1, ET_Aand ET_Breceptors, and ECE and distribution of endothelin-1 in failing rat heart

1999 • 90 citations

The discovery of endothelins

1998 • 88 citations

The role of endothelin in the control of adrenocortical function: stimulation of endothelin release by ACTH and the effects of endothelin-1 and endothelin-3 on steroidogenesis in rat and human adrenocortical cells

1991 • 88 citations

Endothelins: polyfunctional cytokines.

1995 • 83 citations

Endothelins: Effect on Matrix Biosynthesis and Proliferation in Normal and Scleroderma Fibroblasts

1998 • 82 citations

Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus.

1995 • 77 citations

Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ETAreceptor antagonist

2000 • 76 citations

The orally active ET(A) receptor antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphe nyl-propionic acid (LU 135252) prevents the development of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated rats.

1997 • 76 citations

Effects of Hypertension, Diabetes Mellitus, and Hypercholesterolemia on Endothelin Type B Receptor–Mediated Nitric Oxide Release From Rat Kidney

1999 • 76 citations

Endothelin-1 Releases Prostacyclin and Inhibits ex vivo Platelet Aggregation in the Anesthetized Rabbit

1989 • 75 citations

Different electrical responses to vasoactive agonists in morphologically distinct smooth muscle cell types.

1994 • 69 citations

Endothelin-1 augments pressor response to angiotensin II infusion in rats.

1992 • 61 citations

Endothelin-1 Stimulates Steroid Secretion of Human Adrenocortical Cells ex Vivo Via Both ETA and ETB Receptor Subtypes

1997 • 59 citations

Endothelin-1 Induces Increased Fibronectin Expression in Human Bronchial Epithelial Cells

1996 • 59 citations

Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins.

1991 • 58 citations

Plasma Endothelin Correlates With Antiendothelial Antibodies in Patients With Mixed Connective Tissue Disease

1995 • 51 citations

The effect of endothelin, neuropeptide Y, calcitonin gene‐related peptide and substance P on neutrophil functions

1993 • 49 citations

The endothelin antagonist bosentan: Hemodynamic effects during normoxia and hypoxic pulmonary hypertension in pigs

1996 • 49 citations

ET-1 released histamine from guinea pig pulmonary but not peritoneal mast cells

1992 • 48 citations

Digital vascular responses and serum endothelin-1 concentrations in primary and secondary Raynaud's phenomenon

2000 • 46 citations

Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis

2001 • 45 citations

Endothelin-1 Regulation of Intercellular Adhesion Molecule-1 Expression in Normal and Sclerodermal Fibroblasts

1998 • 44 citations

Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure

1998 • 44 citations

Activated neutrophil by endothelin-1 caused tissue damage in human umbilical cord

1995 • 44 citations

Elevated plasma endothelin levels in systemic sclerosis

1995 • 44 citations

ALTERED ENDOTHELIN RECEPTOR SUBTYPE EXPRESSION IN HEPATIC INJURY AFTER ISCHEMIA/REPERFUSION

2000 • 43 citations

Elevated Perfusion Pressure Upregulates Endothelin-1 and Endothelin B Receptor Expression in the Rabbit Carotid Artery

2000 • 42 citations

Regulation of aldosterone secretion in patients with chronic congestive heart failure by endothelins

2000 • 35 citations

Endothelin-3 Increases Transmission in the Rabbit Pulmonary Parasympathetic Nervous System

1993 • 35 citations

Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries.

1990 • 34 citations

Endothelin isopeptides evoke Ca2+ signaling and oscillations of cytosolic free [Ca2+] in human mesangial cells

1990 • 34 citations

Management of sclerodermal finger ulcers

1984 • 33 citations

Antiaggregatory and Hypotensive Effects of Endothelin-1 in Beagle Dogs

1991 • 30 citations

Role of thromboxane receptor activation in the bronchospastic response to endothelin

1990 • 30 citations

ET-1 induces mitogenesis in ovine airway smooth muscle cells via ETA and ETB receptors

1997 • 30 citations

Endothelin-1 stimulates aldosterone synthesis in Conn's adenomas via both A and B receptors coupled with the protein kinase C- and cyclooxygenase-dependent signaling pathways.

2000 • 27 citations

Raynaudʼs phenomenon

1990 • 27 citations

Mortality in Systemic Sclerosis (Scleroderma)

1992 • 26 citations

Whole‐body cooling increases plasma endothelin‐1 levels in women with primary Raynaud's phenomenon

1998 • 24 citations

Plasma Endothelin-1 Levels in Takayasu’s Arteritis

1996 • 24 citations

Influence of Pulmonary Blood Pressure and Flow on Endothelin-1 Production in Humans

1995 • 23 citations

Abnormal platelet aggregation in patients with Raynaud's phenomenon.

1989 • 23 citations

An imbalance in plasma prostanoids in patients with Raynaud′s phenomenon and pulmonary vasospasm

1999 • 22 citations

Serotonergic vasoconstriction in human fingers during reflex sympathetic response to cooling

1988 • 22 citations

Effect of Total-Body Cold Exposure on Plasma Concentrations of von Willebrand Factor, Endothelin-1 and Thrombomodulin in Systemic Lupus erythematosus Patients with or without Raynaud’s Phenomenon

1992 • 22 citations

Mechanisms of ET-1 potentiation of angiotensin II stimulation of aldosterone production

1993 • 20 citations

Atteinte pulmonaire au cours de la sclérodermie systémique. Partie II. Hypertension artérielle pulmonaire isolée, cancer bronchopulmonaire, hémorragie alvéolaire

1999 • 17 citations

Increased plasma endothelin-1 immunoreactive levels in vasculitis

1993 • 16 citations

Endothelin-1 and vasculitis

1990 • 10 citations

Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex

2001 • 9 citations

Raynaudʼs phenomenon

1989 • 6 citations

Deleted Work

1955 • 0 citations