Expression of endothelin-1, ET_Aand ET_Breceptors, and ECE and distribution of endothelin-1 in failing rat heart

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

1994 • 1,631 citations

Myocardial infarct size and ventricular function in rats.

1979 • 1,296 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Investigation of the bicinchoninic acid protein assay: Identification of the groups responsible for color formation

1988 • 751 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

1996 • 630 citations

Circulating and tissue angiotensin systems.

1987 • 616 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

Plasma endothelin in chronic heart failure.

1992 • 494 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Role of Endogenous Endothelin in Chronic Heart Failure

1997 • 367 citations

Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.

1991 • 360 citations

Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria

1988 • 347 citations

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.

1993 • 337 citations

A sensitive sandwich-enzyme immunoassay for human endothelin

1989 • 298 citations

Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells

1994 • 291 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Endogenous Endothelin-1 Participates in the Maintenance of Cardiac Function in Rats With Congestive Heart Failure

1996 • 287 citations

Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.

1995 • 267 citations

Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium.

1993 • 262 citations

Elevated endothelin-1 in heart failure and loss of normal response to postural change.

1992 • 251 citations

cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA

1991 • 226 citations

Endothelin‐converting enzymes

1992 • 223 citations

Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

1988 • 203 citations

Increased Plasma Concentrations of Endothelin in Congestive Heart Failure in Humans

1992 • 191 citations

Endothelin-1 Is Produced and Secreted by Neonatal Rat Cardiac Myocytes in Vitro

1993 • 189 citations

Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity

1989 • 184 citations

Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation

1992 • 159 citations

Expression of Renin-Angiotensin System Components in the Heart, Kidneys, and Lungs of Rats With Experimental Heart Failure

1995 • 158 citations

Expression of Endothelin-1, Endothelin-3, Endothelin-Converting Enzyme-1, and Endothelin-A and Endothelin-B Receptor mRNA After Angioplasty-Induced Neointimal Formation in the Rat

1996 • 146 citations

Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors

1989 • 98 citations

Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum‐free medium

1990 • 92 citations

Identification and activation of autocrine renin-angiotensin system in adult ventricular myocytes

1995 • 88 citations

Increased cardiac expression of endothelin-1 mRNA in ischemic heart failure in rats

1997 • 73 citations

Endothelin-Converting Enzyme

1998 • 57 citations

Angiotensin-Converting Enzyme and Genetic Hypertension: Cloning of Rat cDNAs and Characterization of the Enzyme

1994 • 57 citations

Endothelin stimulates degradation of phospholipids in isolated rat hearts

1991 • 51 citations

Cytotoxic effect of endothelin-1 during ‘simulated’ ischaemia in cultured rat myocytes

1991 • 35 citations

Altered Expression of Isoforms of Myosin Heavy Chain mRNA in the Failing Rat Heart Is Ameliorated by Chronic Treatment with an Endothelin Receptor Antagonist

1998 • 19 citations

Endothelin-1 secretion by human fibroblasts in culture: effects of cell density and IFN-beta.

1991 • 16 citations