The orally active ET(A) receptor antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphe nyl-propionic acid (LU 135252) prevents the development of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated rats.

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.

1992 • 653 citations

Molecular characterization of endothelin receptors

1992 • 601 citations

Growth regulatory properties of endothelins

1993 • 342 citations

Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation.

1991 • 340 citations

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.

1993 • 337 citations

Endothelin ET_A and ET_B receptors mediate vascular smooth muscle contraction

1992 • 286 citations

Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ET_Breceptors

1996 • 286 citations

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

1994 • 252 citations

ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat

1995 • 170 citations

Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure

1994 • 168 citations

BQ123, an ET_A Receptor Antagonist, Inhibits Endothelin-1-mediated Proliferation of Human Pulmonary Artery Smooth Muscle Cells

1993 • 130 citations

Endothelin in hypertensive resistance arteries. Intraluminal and extraluminal dysfunction.

1991 • 122 citations

Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists

1996 • 116 citations

Elimination of Intravenously Injected Endothelin-1 from the Circulation of the Rat

1989 • 112 citations

Endothelin stimulates protein synthesis in smooth muscle cells

1992 • 83 citations

Importance of Angiotensin-Converting Enzyme in Pulmonary Hypertension

1995 • 66 citations

PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats

1992 • 64 citations

Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium

1996 • 53 citations

Lung Vascular Injury from Monocrotaline Pyrrole, a Putative Hepatic Metabolite

1991 • 50 citations

Kinetics of pulmonary angiotensin-converting enzyme and 5'-nucleotidase in vivo

1984 • 47 citations

Pulmonary removal and production of endothelin in the anesthetized dog

1994 • 39 citations

Receptor Selectivity of Endothelin Antagonists and Prevention of Vasoconstriction and Endothelin-Induced Sudden Death

1995 • 32 citations

Impaired pulmonary conversion of angiotensin I to angiotensin II in rats exposed to chronic hypoxia

1986 • 29 citations

Correlation of pulmonary ACE activity and capillary surface area during postnatal development

1987 • 28 citations

Pulmonary angiotensin-converting enzyme substrate hydrolysis during exercise

1992 • 27 citations

Pulmonary arterial smooth muscle contractility in hypoxia-induced pulmonary hypertension

1994 • 23 citations

Enalapril improves heart failure induced by monocrotaline without reducing pulmonary hypertension in rats: roles of preserved myocardial creatine kinase and lactate dehydrogenase isoenzymes

1995 • 20 citations

Early pulmonary endothelial enzyme dysfunction after phorbol ester in conscious rabbits

1987 • 15 citations

Effect of Verapamil on Monocrotaline-Induced Pulmonary Artery Hypertension and Endothelial Cell Dysfunction in Rats

1990 • 14 citations

Effects of alveolar pressure on lung angiotensin-converting enzyme function in vivo

1986 • 13 citations

Effect of flow and surface area on angiotensin-converting enzyme activity in rabbit lungs

1987 • 12 citations

Alteration of fate of vasoactive autacoids in pulmonary circulation following monocrotaline‐induced lung vascular injury in rats

1988 • 6 citations