The Toll-IL-1R Member Tir8/SIGIRR Negatively Regulates Adaptive Immunity against Kidney Grafts

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Banff 97 working classification of renal allograft pathology

1999 • 3,028 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 • 2,031 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Negative regulation of Toll-like receptor-mediated immune responses

2005 • 1,487 citations

HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression

2008 • 935 citations

Dendritic Cells: Translating Innate to Adaptive Immunity

2006 • 823 citations

TLR4 activation mediates kidney ischemia/reperfusion injury

2007 • 796 citations

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

2005 • 794 citations

SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

2003 • 580 citations

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

2005 • 544 citations

Dendritic cell subsets in health and disease

2007 • 424 citations

THE BENEFICIAL EFFECT OF HUMAN RECOMBINANT SUPEROXIDE DISMUTASE ON ACUTE AND CHRONIC REJECTION EVENTS IN RECIPIENTS OF CADAVERIC RENAL TRANSPLANTS

1994 • 392 citations

Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia–reperfusion injury

2007 • 342 citations

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

2003 • 305 citations

The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis

2007 • 301 citations

CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney

2006 • 292 citations

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

2003 • 261 citations

The Role of Postischemic Reperfusion Injury and Other Nonantigen-Dependent Inflammatory Pathways in Transplantation

2005 • 257 citations

Intestinal inflammation in mice deficient in Tir8 , an inhibitory member of the IL-1 receptor family

2004 • 248 citations

Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo

2006 • 243 citations

Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells

2002 • 243 citations

TLR Engagement Prevents Transplantation Tolerance

2006 • 216 citations

Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3− precursors

2007 • 196 citations

The Role of Hyaluronan Degradation Products as Innate Alloimmune Agonists

2006 • 195 citations

Ischemia-Reperfusion Injury Activates Innate Immunity in Rat Kidneys

2005 • 185 citations

<scp>l</scp> -Arginine Depletion in Preeclampsia Orients Nitric Oxide Synthase Toward Oxidant Species

2004 • 155 citations

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction

2004 • 152 citations

Toll‐like receptors and immune regulation: their direct and indirect modulation on regulatory CD4⁺ CD25⁺ T cells

2007 • 152 citations

TNF-α Drives Human CD14+ Monocytes to Differentiate into CD70+ Dendritic Cells Evoking Th1 and Th17 Responses

2007 • 149 citations

Role of IL-1 in renal ischemic reperfusion injury.

1998 • 149 citations

PATTERN OF LIVER, KIDNEY, HEART, AND INTESTINE ALLOGRAFT REJECTION IN DIFFERENT MOUSE STRAIN COMBINATIONS1

1996 • 146 citations

Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney

2005 • 139 citations

TH1 Immune Responses to Fully MHC Mismatched Allografts are Diminished in the Absence of MyD88, a Toll-Like Receptor Signal Adaptor Protein

2004 • 126 citations

Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

2008 • 122 citations

Innate Immunity and Organ Transplantation: The Potential Role of Toll-like Receptors

2005 • 121 citations

Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.

2004 • 118 citations

Damping Excessive Inflammation and Tissue Damage in Mycobacterium tuberculosis Infection by Toll IL-1 Receptor 8/Single Ig IL-1-Related Receptor, a Negative Regulator of IL-1/TLR Signaling

2007 • 116 citations

Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection

2008 • 115 citations

Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8, an Inhibitory Member of the Interleukin-1 Receptor Family

2007 • 113 citations

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

2008 • 113 citations

Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance

2006 • 110 citations

T Regulatory Cells Contribute to the Attenuated Primary CD8+ and CD4+ T Cell Responses to Herpes Simplex Virus Type 2 in Neonatal Mice

2008 • 105 citations

Pertussis Toxin by Inducing IL-6 Promotes the Generation of IL-17-Producing CD4 Cells

2007 • 102 citations

Mechanisms Underlying Blockade of Allograft Acceptance by TLR Ligands

2008 • 88 citations

The T helper 17–regulatory T cell axis in transplant rejection and tolerance

2009 • 84 citations

SIGIRR Promotes Resistance againstPseudomonas aeruginosaKeratitis by Down-Regulating Type-1 Immunity and IL-1R1 and TLR4 Signaling

2006 • 78 citations

Toll-Like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/Reperfusion

2007 • 78 citations

IL-1β-Driven ST2L Expression Promotes Maturation Resistance in Rapamycin-Conditioned Dendritic Cells

2008 • 77 citations

The Role of Toll-like Receptors in Solid Organ Transplantation

2006 • 74 citations

Graft Produced Interleukin-6 Functions as a Danger Signal and Promotes Rejection After Transplantation

2007 • 73 citations

Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: the new entry TIR8/SIGIRR

2003 • 67 citations

Murine Renal Allografts: Spontaneous Acceptance Is Associated with Regulated T Cell-Mediated Immunity

2001 • 66 citations

Cold ischemia augments allogeneic-mediated injury in rat kidney allografts

2001 • 63 citations

Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells

2007 • 62 citations

Induction of Human Dendritic Cell Maturation Using Transfection with RNA Encoding a Dominant Positive Toll-Like Receptor 4

2004 • 60 citations

Frontiers in Nephrology

2007 • 44 citations

Anti-CD25 mAb Administration Prevents Spontaneous Liver Transplant Tolerance

2006 • 43 citations

Ultra-Localization of Foxp3+ T Cells within Renal Allografts Shows Infiltration of Tubules Mimicking Rejection

2007 • 37 citations

Differential Impact of CD154 Costimulation Blockade on Alloreactive Effector and Regulatory T Cells in Murine Renal Transplant Recipients

2008 • 30 citations

Clinical transplantation tolerance: The promise and challenges

2004 • 21 citations

Antagonistic Effect of Toll-Like Receptor Signaling and Bacterial Infections on Transplantation Tolerance

2009 • 21 citations

Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance

2006 • 6 citations

Role of thymic- and graft-dependent mechanisms in tolerance induction to rat kidney transplant by donor PBMC infusion

2007 • 4 citations

Cold ischemia augments allogeneic-mediated injury in rat kidney allografts

2001 • 3 citations