Airway remodeling in asthma

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

A 15-Year Follow-up Study of Ventilatory Function in Adults with Asthma

1998 • 1,266 citations

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1989 • 1,151 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

The Mechanics of Airway Narrowing in Asthma

1989 • 805 citations

Myofibroblasts and Subepithelial Fibrosis in Bronchial Asthma

1990 • 670 citations

Eosinophil-associated TGF- β₁mRNA Expression and Airways Fibrosis in Bronchial Asthma

1997 • 639 citations

Cellular Hypertrophy and Hyperplasia of Airway Smooth Muscles Underlying Bronchial Asthma: A 3-D Morphometric Study

1993 • 625 citations

Small Airways Dimensions in Asthma and in Chronic Obstructive Pulmonary Disease

1993 • 594 citations

Transforming Growth Factor- β Expression in Mucosal Biopsies in Asthma and Chronic Bronchitis

1997 • 566 citations

Effects of Treatment on Airway Inflammation and Thickening of Basement Membrane Reticular Collagen in Asthma: A Quantitative Light and Electron Microscopic Study

1992 • 548 citations

THE PATHOLOGY OF BRONCHIAL ASTHMA

1922 • 543 citations

Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma

1997 • 527 citations

Marked Goblet Cell Hyperplasia with Mucus Accumulation in the Airways of Patients Who Died of Severe Acute Asthma Attack

1992 • 513 citations

A Model of Airway Narrowing in Asthma and in Chronic Obstructive Pulmonary Disease

1992 • 457 citations

Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness

1998 • 448 citations

Rate of decline of lung function in subjects with asthma.

1987 • 432 citations

Airways Remodeling Is a Distinctive Feature of Asthma and Is Related to Severity of Disease

1997 • 396 citations

Sputum Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Correlates with Airflow Obstruction in Asthma and Chronic Bronchitis

1998 • 396 citations

Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma

1992 • 395 citations

Interleukin-11: Review of Molecular, Cell Biology, and Clinical Use

1997 • 386 citations

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

1996 • 355 citations

Airway Inflammation in Mild Intermittent and in Persistent Asthma

1998 • 322 citations

Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation☆☆☆★★★

1998 • 277 citations

Myofibroblast involvement in the allergen-induced late response in mild atopic asthma.

1997 • 277 citations

Pathophysiology of asthma

1996 • 275 citations

Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation.

1996 • 252 citations

Interleukin 9: A candidate gene for asthma

1997 • 236 citations

Collagen Deposition in Large Airways May Not Differentiate Severe Asthma from Milder Forms of the Disease

1998 • 232 citations

Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.

1996 • 220 citations

Expression of growth factors and remodelling of the airway wall in bronchial asthma

1998 • 217 citations

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.

1994 • 215 citations

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.

1996 • 213 citations

Lung inflammation and epithelial changes in a murine model of atopic asthma.

1996 • 208 citations

Hyperplasia of bronchial muscle in asthma

1973 • 202 citations

Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction.

1995 • 188 citations

Airway wall remodeling after cessation of exposure to isocyanates in sensitized asthmatic subjects.

1995 • 125 citations

Hyperplasia of bronchial muscle in chronic bronchitis

1970 • 105 citations

Airway goblet cell mucin: its structure and regulation of secretion

1997 • 102 citations

IL-1 beta and IL-6 induce hyperplasia and hypertrophy of cultured guinea pig airway smooth muscle cells

1995 • 96 citations

Interleukin-4 Alters Epithelial Cell Differentiation and Surfactant Homeostasis in the Postnatal Mouse Lung

1997 • 84 citations

The functional consequences of airway remodeling in asthma.

1997 • 82 citations

Airway smooth muscle in asthma: flirting with disaster

1998 • 78 citations

Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-beta 1 expression in brown Norway rats.

1996 • 73 citations

Increased expression of tissue inhibitor of metalloproteinase-1 and loss of correlation with matrix metalloproteinase-9 by macrophages in asthma.

1999 • 63 citations

Interleukin-11

1997 • 61 citations

New Insights into Airway Inflammation by Endobronchial Biopsy

1992 • 53 citations

The bronchial basement membrane in asthma.

1966 • 35 citations

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