Induction of cyclo‐oxygenase‐2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Structure of the human cyclo-oxygenase-2 gene

1994 • 488 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Cyclooxygenase-2: Regulation and relevance in inflammation

1995 • 368 citations

Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

1995 • 312 citations

Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone

1994 • 311 citations

Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes.

1994 • 310 citations

Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

1996 • 228 citations

Effect of Inhaled Prostaglandin E₂on Allergen-induced Asthma

1993 • 203 citations

Cytokines as Mediators of Chronic Asthma

1994 • 194 citations

Significance of thromboxane generation in ozone-induced airway hyperresponsiveness in dogs

1985 • 159 citations

Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells

1996 • 153 citations

Quantifying Proliferation of Cultured Human and Rabbit Airway Smooth Muscle Cells in Response to Serum and Platelet-derived Growth Factor

1992 • 138 citations

Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects.

1986 • 135 citations

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

1992 • 129 citations

Interleukin-1 Differentially Modulates Chondrocyte Expression of Cyclooxygenase-2 and Phospholipase A2

1993 • 109 citations

Inhibition of antigen-induced airway hyperresponsiveness by a thromboxane synthetase inhibitor (OKY-046) in allergic dogs.

1986 • 108 citations

Effect of inhaled prostaglandin E2 on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma.

1991 • 78 citations

Production of PGE₂ by bovine cultured airway smooth muscle cells and its inhibition by cyclo‐oxygenase inhibitors

1994 • 75 citations

Role and mechanism of thromboxane-induced proliferation of cultured airway smooth muscle cells

1992 • 58 citations

Aspects of Bronchial Reactivity to Prostaglandins and Aspirin in Asthmatic Patients

1977 • 55 citations

Dexamethasone Suppression of IL-1β-Induced Cyclooxygenase 2 Expression Is Not Mediated by Lipocortin-1 in A549 Cells

1994 • 49 citations

Clinical, functional and pathogenetic aspects of bronchial reactivity to prostaglandins F2alpha, E1, and E2.

1976 • 41 citations

Secretory Non‐Pancreatic Phospholipase A₂ and cyclooxygenase‐2 Expression by Tracheobronchial Smooth Muscle Cells

1996 • 41 citations

Human airway smooth muscle in culture

1988 • 31 citations

Leukotrienes as mediators of airway obstruction and inflammation in asthma

1995 • 28 citations