Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology

The importance of the ratio of omega-6/omega-3 essential fatty acids

2002 • 3,728 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Cognitive and Behavioral Outcomes of School-Aged Children Who Were Born Preterm

2002 • 2,323 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Essential fatty acids in health and chronic disease

1999 • 1,704 citations

Developmental Trajectories of Brain Volume Abnormalities in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder

2002 • 1,610 citations

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

2000 • 1,565 citations

Handbook of Milk Composition

1995 • 1,169 citations

Regional Deficits in Brain Volume in Schizophrenia: A Meta-Analysis of Voxel-Based Morphometry Studies

2005 • 1,125 citations

Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder

2002 • 1,092 citations

The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina

2001 • 1,041 citations

Polyunsaturated fatty acids in the food chain in the United States

2000 • 1,017 citations

Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia

1990 • 1,009 citations

Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants

2000 • 976 citations

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 • 966 citations

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

2003 • 965 citations

Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys.

1986 • 922 citations

Maternal Supplementation With Very-Long-Chain n-3 Fatty Acids During Pregnancy and Lactation Augments Children’s IQ at 4 Years of Age

2003 • 921 citations

Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults

2005 • 852 citations

Actin-Based Plasticity in Dendritic Spines

2000 • 813 citations

Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia

2001 • 812 citations

Tissue levels of polyunsaturated fatty acids during early human development

1992 • 804 citations

Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants

1994 • 797 citations

Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements

1980 • 777 citations

Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

1998 • 705 citations

Structural Brain Imaging of Attention-Deficit/Hyperactivity Disorder

2005 • 664 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.

1984 • 653 citations

Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease

1991 • 645 citations

Physiological compartmental analysis of α-linolenic acid metabolism in adult humans

2001 • 578 citations

Infant cerebral cortex phospholipid fatty-acid composition and diet

1992 • 569 citations

Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder

2003 • 565 citations

Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia

1990 • 543 citations

Development of the dopaminergic innervation in the prefrontal cortex of the rat

1988 • 533 citations

A case of human linolenic acid deficiency involving neurological abnormalities

1982 • 529 citations

Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation

1993 • 520 citations

Attention, Memory, and Motor Skills as Childhood Predictors of Schizophrenia-Related Psychoses: The New York High-Risk Project

2000 • 507 citations

Maternal Fish Consumption, Hair Mercury, and Infant Cognition in a U.S. Cohort

2005 • 490 citations

Schizophrenia as a Long-Term Outcome of Pregnancy, Delivery, and Perinatal Complications: A 28-Year Follow-Up of the 1966 North Finland General Population Birth Cohort

1998 • 486 citations

Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration

1992 • 485 citations

Essential fatty acids in visual and brain development

2001 • 474 citations

Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age

1998 • 474 citations

Attention Deficit Hyperactivity Disorders and Other Psychiatric Outcomes in Very Low Birthweight Children at 12 Years

1997 • 468 citations

Child Health

2003 • 459 citations

Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder

1995 • 448 citations

Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients With Schizophrenia

1998 • 441 citations

Schizophrenia and smoking: an epidemiological survey in a state hospital

1995 • 426 citations

Behavioral Deficits Associated with Dietary Induction of Decreased Brain Docosahexaenoic Acid Concentration

2000 • 422 citations

Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins

2003 • 415 citations

Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?

1998 • 408 citations

Adolescents who were born very preterm have decreased brain volumes

2002 • 405 citations

Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm

1999 • 399 citations

Docosahexaenoic acid promotes neurite growth in hippocampal neurons

2004 • 398 citations

Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients

2003 • 392 citations

Regional Frontal Cortical Volumes Decrease Differentially in Aging: An MRI Study to Compare Volumetric Approaches and Voxel-Based Morphometry

2002 • 387 citations

Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia

1999 • 383 citations

A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties

2002 • 382 citations

Reduced Dorsal and Orbital Prefrontal Gray Matter Volumes in Schizophrenia

2000 • 375 citations

A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder

2001 • 365 citations

Hippocampal Volume in First-Episode Psychoses and Chronic Schizophrenia

1999 • 364 citations

Magnetic resonance imaging of brain in people at high risk of developing schizophrenia

1999 • 362 citations

Structural Abnormalities of Subicular Dendrites in Subjects With Schizophrenia and Mood Disorders

2000 • 357 citations

Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study

2002 • 353 citations

Randomised clinical trials of fish oil supplementation in high risk pregnancies

2000 • 353 citations

Imaging the Effects of Methylphenidate on Brain Dopamine: New Model on Its Therapeutic Actions for Attention-Deficit/Hyperactivity Disorder

2005 • 353 citations

Neurodevelopmental Quotient of Healthy Term Infants at 4 Months and Feeding Practice: The Role of Long-Chain Polyunsaturated Fatty Acids

1995 • 351 citations

Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens.

1999 • 351 citations

Similar Effects on Infants of n-3 and n-6 Fatty Acids Supplementation to Pregnant and Lactating Women

2001 • 350 citations

Fatty Acid Composition of Human Brain Phospholipids During Normal Development

1998 • 350 citations

EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors

2003 • 337 citations

Fish Intake During Pregnancy and Early Cognitive Development of Offspring

2004 • 337 citations

A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months

1996 • 337 citations

α‐Linolenic Acid Dietary Deficiency Alters Age‐Related Changes of Dopaminergic and Serotoninergic Neurotransmission in the Rat Frontal Cortex

1996 • 336 citations

Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys.

1990 • 335 citations

A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms

2002 • 332 citations

Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia

2001 • 330 citations

Visual Acuity, Erythrocyte Fatty Acid Composition, and Growth in Term Infants Fed Formulas with Long Chain Polyunsaturated Fatty Acids for One Year

1997 • 328 citations

Delivery and turnover of plasma-derived essential PUFAs in mammalian brain

2001 • 321 citations

DOPA Decarboxylase Activity in Attention Deficit Hyperactivity Disorder Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study

1998 • 320 citations

Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions

1995 • 319 citations

Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia

2002 • 315 citations

Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta

2000 • 315 citations

Phosphorylation and Regulation of Antidepressant-sensitive Serotonin Transporters

1998 • 312 citations

Schizophrenia and Complications of Pregnancy and Labor: An Individual Patient Data Meta-analysis

1999 • 310 citations

Randomized, Placebo-Controlled Study of Ethyl-Eicosapentaenoic Acid as Supplemental Treatment in Schizophrenia

2002 • 303 citations

Motor, cognitive, and behavioural disorders in children born very preterm

2003 • 293 citations

Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula

1986 • 292 citations

Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics

2002 • 287 citations

Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats

1998 • 286 citations

Supplementation with a combination of ω-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia

2002 • 284 citations

Maternal DHA and the Development of Attention in Infancy and Toddlerhood

2004 • 284 citations

The effect of variations in dietary fatty acids on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidylethanolamine in human infants

1982 • 283 citations

Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

2001 • 281 citations

Obstetric complications and risk of schizophrenia

2001 • 279 citations

Reduced Neuronal Size in Posterior Hippocampus of Schizophrenic Patients

1991 • 276 citations

Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia

2001 • 274 citations

Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients

2000 • 274 citations

The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects

2001 • 269 citations

Omega-3 fatty acids and rodent behavior

2006 • 261 citations

Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex.

1995 • 259 citations

The Slow Discovery of the Importance of ω3 Essential Fatty Acids in Human Health

1998 • 258 citations

Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition.

1996 • 257 citations

The Dopamine Transporter Constitutively Internalizes and Recycles in a Protein Kinase C-regulated Manner in Stably Transfected PC12 Cell Lines

2003 • 257 citations

Decline in fish consumption among pregnant women after a national mercury advisory

2003 • 254 citations

Fatty acid levels in the brains of schizophrenics and normal controls

1991 • 250 citations

Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid

2005 • 246 citations

Clinical Characteristics and Serum Essential Fatty Acid Levels in Hyperactive Children

1987 • 245 citations

Growth impairment in the very preterm and cognitive and motor performance at 7 years

2003 • 244 citations

Motor, cognitive, and behavioural disorders in children born very preterm

2003 • 244 citations

Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants?

2001 • 240 citations

One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats

2005 • 239 citations

Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat

2004 • 236 citations

Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants

2005 • 236 citations

Magnetic resonance imaging correlates of attention-deficit/hyperactivity disorder in children.

2003 • 235 citations

A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy

2003 • 230 citations

Stereoacuity at age 3.5 y in children born full-term is associated with prenatal and postnatal dietary factors: a report from a population–based cohort study

2001 • 225 citations

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Produces Reversible Inhibition of Phospholipase C by Sequestering Phosphatidylinositol 4,5-Bisphosphate in Lateral Domains

1996 • 223 citations

Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex

2002 • 221 citations

The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia

1992 • 218 citations

Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for ‘hypofrontality’

1999 • 216 citations

Lateral Sequestration of Phosphatidylinositol 4,5-Bisphosphate by the Basic Effector Domain of Myristoylated Alanine-rich C Kinase Substrate Is Due to Nonspecific Electrostatic Interactions

2002 • 216 citations

The dopamine mesocorticolimbic pathway is affected by deficiency in n−3 polyunsaturated fatty acids

2002 • 215 citations

Recovery of brain docosahexaenoate leads to recovery of spatial task performance

2003 • 210 citations

Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants

2005 • 210 citations

Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

2000 • 210 citations

Volumes of Brain Structures in Twins Discordant for Schizophrenia

2001 • 210 citations

Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat

2006 • 208 citations

Relationship of Obstetric Complications and Differences in Size of Brain Structures in Monozygotic Twin Pairs Discordant for Schizophrenia

2000 • 207 citations

Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk

2003 • 198 citations

Docosahexaenoic and Arachidonic Acid Prevent a Decrease in Dopaminergic and Serotoninergic Neurotransmitters in Frontal Cortex Caused by a Linoleic and α-Linolenic Acid Deficient Diet in Formula-fed Piglets

1999 • 197 citations

The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system

2005 • 197 citations

Polyunsaturated Fatty Acids in Human Milk

2004 • 195 citations

Specific phospholipid fatty acid composition of brain regions in mice: effects of n–3 polyunsaturated fatty acid deficiency and phospholipid supplementation

2000 • 193 citations

α‐Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid

2005 • 191 citations

Preterm Children Have Disturbances of White Matter at 11 Years of Age as Shown by Diffusion Tensor Imaging

2003 • 189 citations

Long-chain polyunsaturated fatty acid transport across the perfused human placenta

1997 • 187 citations

Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group

2001 • 186 citations

Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology

2005 • 183 citations

Half‐lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n‐3 polyunsaturated fatty acids

2004 • 182 citations

A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months

1996 • 181 citations

Adult rat brain synaptic vesicles II. Lipid composition

1973 • 181 citations

Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan

2004 • 178 citations

Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum

2001 • 177 citations

Visual and brain function measurements in studies of n-3 fatty acid requirements of infants

1992 • 173 citations

Women with schizophrenia: pregnancy outcome and infant death among their offspring

2002 • 171 citations

Early Focused Attention Predicts Outcome for Children Born Prematurely

2004 • 170 citations

Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus

2003 • 165 citations

Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex

2000 • 164 citations

Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy

1995 • 163 citations

Acute effects of dietary fatty acids on the fatty acids of human milk

1998 • 160 citations

Polyunsaturated fatty acid status and neurodevelopment: A summary and critical analysis of the literature

1999 • 159 citations

Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy

1996 • 158 citations

Psychopathology in Females with Attention-Deficit/Hyperactivity Disorder: A Controlled, Five-Year Prospective Study

2006 • 158 citations

Phospholipid supplementation reverses behavioral and biochemical alterations induced by n–3 polyunsaturated fatty acid deficiency in mice

2000 • 158 citations

Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins.

1998 • 157 citations

Reduced Red Blood Cell Membrane Essential Polyunsaturated Fatty Acids in First Episode Schizophrenia at Neuroleptic-Naive Baseline

2004 • 157 citations

Smaller Anterior Hippocampal Formation Volume in Antipsychotic-Naive Patients With First-Episode Schizophrenia

2003 • 156 citations

Maternal fish oil supplementation in lactation: Effect on visual acuity and n−3 fatty acid content of infant erythrocytes

2004 • 156 citations

Neurodevelopmental follow-up after preterm birth: follow up after two years

2006 • 156 citations

Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment

2003 • 154 citations

Fat consumption and schizophrenia

1988 • 154 citations

Omega-3 fatty acid content of the US food supply.

1992 • 152 citations

Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning,,,

2002 • 151 citations

Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients

1995 • 151 citations

Protein Kinase C Mediates Phosphorylation, Desensitization, and Trafficking of the D2 Dopamine Receptor

2004 • 150 citations

Premorbid indicators and risk for schizophrenia: A selective review and update

2005 • 147 citations

Brain morphology in first-episode schizophrenia

1995 • 147 citations

Development of the catecholamine neurons in human embryos and fetuses, with special emphasis on the innervaton of the cerebral cortex

1995 • 145 citations

Decrease in neuron size in docosahexaenoic acid-deficient brain

2002 • 145 citations

Developmental changes in rat brain membrane lipids and fatty acids: the preferential prenatal accumulation of docosahexaenoic acid

1999 • 144 citations

The Nithsdale Schizophrenia Survey

1987 • 143 citations

Overexpression of ∊-Protein Kinase C Enhances Nerve Growth Factor-induced Phosphorylation of Mitogen-activated Protein Kinases and Neurite Outgrowth

1995 • 143 citations

Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia

2002 • 138 citations

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition

2004 • 137 citations

Docosahexaenoic Acid Abundance in the Brain: A biodevice to Combat Oxidative Stress

2002 • 136 citations

Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats:critical role of developmental stage

2002 • 136 citations

Long-Term Behavioral Sequelae of Prematurity

1996 • 133 citations

Bioequivalence of Dietary α-Linolenic and Docosahexaenoic Acids as Sources of Docosahexaenoate Accretion in Brain and Associated Organs of Neonatal Baboons

1999 • 132 citations

n−3 Fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues

2000 • 131 citations

Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia

2002 • 131 citations

Dietary Fatty Acid Composition in Pregnancy Alters Neurite Membrane Fatty Acids and Dopamine in Newborn Rat Brain

2001 • 129 citations

Psychological Findings in Preterm Children Related to Neurologic Status and Magnetic Resonance Imaging

1998 • 129 citations

Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD)

2005 • 129 citations

How actin filaments and microtubules steer growth cones to their targets

2003 • 128 citations

The New York high risk project to the Hillside recognition and prevention (RAP) program

2002 • 128 citations

A comparison of the influence of breast-feeding and bottle-feeding on the fatty acid composition of the erythrocytes

1979 • 127 citations

OMEGA-3 FATTY ACIDS IN MATERNAL ERYTHROCYTES AND RISK OF PREECLAMPSIA

1995 • 126 citations

Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation

2003 • 125 citations

Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder

2003 • 123 citations

Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice.

1993 • 123 citations

Brain phospholipases A2: a perspective on the history

2004 • 121 citations

Dietary n-3 Fatty Acid Deficiency Decreases Nerve Growth Factor Content in Rat Hippocampus.

2001 • 121 citations

The corpus callosum and lateral ventricles in children with attention-deficit hyperactivity disorder: A brain magnetic resonance imaging study

1996 • 119 citations

Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum

2001 • 119 citations

Alterations in Brain Function After Loss of Docosahexaenoate Due to Dietary Restriction of n-3 Fatty Acids

2001 • 118 citations

Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse.

1997 • 118 citations

Cortical gray matter volume deficit in patients with first-episode schizophrenia

1996 • 118 citations

Visual attention in infant monkeys: Effects of dietary fatty acids and age.

1997 • 116 citations

Changing Fatty Acid Content of Growth Cone Lipids Prior to Synaptogenesis

1992 • 115 citations

Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study

1998 • 115 citations

Synaptic Vesicle Ultrastructural Changes in the Rat Hippocampus Induced by a Combination of α‐Linolenate Deficiency and a Learning Task

1997 • 114 citations

Olfactory discrimination deficits in n−3 fatty acid-deficient rats

2001 • 112 citations

Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment.

2001 • 112 citations

Binding of Peptides with Basic and Aromatic Residues to Bilayer Membranes

2003 • 111 citations

Home cage behavior of rhesus monkeys with long-term deficiency of omega-3 fatty acids

1994 • 109 citations

A Decrease in Cell Size Accompanies a Loss of Docosahexaenoate in the Rat Hippocampus

2002 • 107 citations

Effect of Maternal Polyunsaturated Fatty Acid Concentration on Transport by the Human Placenta

1999 • 105 citations

Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder

2004 • 105 citations

Maternal docosahexaenoic acid supplementation and fetal accretion

2003 • 105 citations

Psychosis proneness and ADHD in young relatives of schizophrenia patients

2002 • 103 citations

Can Prenatal N-3 Fatty Acid Deficiency Be Completely Reversed after Birth? Effects on Retinal and Brain Biochemistry and Visual Function in Rhesus Monkeys

2005 • 103 citations

Preterm birth and intra-uterine growth retardation among children of women with schizophrenia

1999 • 103 citations

The regulation of neurotransmitter secretion by protein kinase C

1998 • 101 citations

Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release.

1997 • 99 citations

Outcome-based comparison of Ritalin versus food-supplement treated children with AD/HD.

2003 • 94 citations

Differential effects of n-3 fatty acid deficiency on phospholipid molecular species composition in the rat hippocampus

2002 • 93 citations

Dietary α-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes

1992 • 91 citations

Rapid incorporation of docosahexaenoic acid from dietary sources into brain microsomal, synaptosomal and mitochondrial membranes in adult mice.

1997 • 91 citations

Internalization and recycling of 5-HT _2A receptors activated by serotonin and protein kinase C-mediated mechanisms

2002 • 90 citations

Myristoylated Alanine-rich C Kinase Substrate (MARCKS) Sequesters Spin-labeled Phosphatidylinositol 4,5-Bisphosphate in Lipid Bilayers

2002 • 90 citations

Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain

2005 • 89 citations

Infant cerebellar gray and white matter fatty acids in relation to age and diet

1999 • 89 citations

Fluctuations in human milk long‐chain PUFA levels in relation to dietary fish intake

2002 • 88 citations

Learning Disability, Attention-Deficit Disorder, and Language Impairment as Outcomes of Prematurity

1998 • 81 citations

Calcium signalling in growth cone migration

2005 • 79 citations

Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity

2004 • 79 citations

Polydipsia in rhesus monkeys deficient in omega-3 fatty acids

1990 • 77 citations

Immunocytochemical evidence of well-developed dopaminergic and noradrenergic innervations in the frontal cerebral cortex of human fetuses at midgestation

1993 • 74 citations

The Influence of Prematurity and Long Chain Polyunsaturate Supplementation in 4-Week Adjusted Age Baboon Neonate Brain and Related Tissues

2003 • 73 citations

Supplementation of grazing dairy cows with rumen-protected tuna oil enriches milk fat with n-3 fatty acids without affecting milk production or sensory characteristics

2004 • 72 citations

Modulation of phosphoinositide–protein kinase C signal transduction by omega-3 fatty acids: Implications for the pathophysiology and treatment of recurrent neuropsychiatric illness

2006 • 71 citations

Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants

1996 • 71 citations

Fatty acid composition of late embryonic and early postnatal rat brain

1996 • 70 citations

Omega-3 fatty acids as a psychotherapeutic agent for a pregnant schizophrenic patient

2001 • 67 citations

Dietary supplementation of long‐chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation

2002 • 66 citations

Is increased D2 receptor availability associated with response to stimulant medication in ADHD

2001 • 65 citations

Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth conesof PC12 cells

1998 • 65 citations

Polyunsaturated fatty acids in maternal plasma and in breast milk

2002 • 65 citations

Chronic dietary n‐3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum

1998 • 64 citations

Gestational Age Dependency of Essential Fatty Acids in Cord Plasma Cholesterol Esters and Triglycerides

1994 • 64 citations

Corpus callosum in first-episode patients with schizophrenia – a magnetic resonance imaging study

2003 • 63 citations

Incorporation oftrans long‐chain n−3 polyunsaturated fatty acids in rat brain structures and retina

1994 • 63 citations

Maternal dietary 22: 6n-3 is more effective than 18: 3n-3 in increasing the 22: 6n-3 content in phospholipids of glial cells from neonatal rat brain

2005 • 61 citations

Molecular Species of Diacylglycerols and Phosphoglycerides and the Postmortem Changes in the Molecular Species of Diacylglycerols in Rat Brains

1991 • 60 citations

Methylphenidate‐Evoked Potentiation of Extracellular Dopamine in the Brain of Adolescents with Premature Birth

2002 • 58 citations

Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates

2004 • 58 citations

n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain

2002 • 58 citations

Sudden infant death syndrome: Effect of breast and formula feeding on frontal cortex and brainstem lipid composition

1995 • 57 citations

The Nithsdale Schizophrenia Surveys 16. Breast-feeding and schizophrenia: Preliminary results and hypotheses

1997 • 56 citations

Neural maturation of breastfed and formula‐fed infants

2004 • 56 citations

Structural and Functional Importance of Dietary Polyunsaturated Fatty Acids in the Nervous System

1992 • 54 citations

Effects of omega-3 fatty acids on mental health.

2005 • 54 citations

Short Communication

2004 • 51 citations

A randomized controlled trial of the effect of fish oil supplementation in late pregnancy and early lactation on the n−3 fatty acid content in human breast milk

2004 • 51 citations

Reduction of the synaptophysin level but normal levels of glycerophospholipids in the gyrus cinguli in schizophrenia

2002 • 50 citations

Corpus callosum development in childhood-onset schizophrenia

2003 • 50 citations

Dietary n−3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids

2000 • 49 citations

Reduced Brain DHA Content After a Single Reproductive Cycle in Female Rats Fed a Diet Deficient in N-3 Polyunsaturated Fatty Acids

2006 • 48 citations

Ultrastructural analysis of the paranodal junction of myelinated fibers in 31‐month‐old‐rats

2002 • 48 citations

Structural brain abnormalities specific to childhood-onset schizophrenia identified by neuroimaging techniques.

2002 • 47 citations

Intra-uterine physical growth in schizophrenia: evidence confirming excess of premature birth

2000 • 43 citations

Docosahexaenoic and Arachidonic Acid Influence on Preterm Baboon Retinal Composition and Function

2003 • 42 citations

Diet (n-3) Polyunsaturated Fatty Acid Content and Parity Interact to Alter Maternal Rat Brain Phospholipid Fatty Acid Composition

2006 • 42 citations

Effects of Dietary n-3 Fatty Acid Deficiency on Morris Water-Maze Performance and Amphetamine-Induced Conditioned Place Preference in Rats

1998 • 41 citations

Effect of three low-dose fish oil supplements, administered during pregnancy, on neonatal long-chain polyunsaturated fatty acid status at birth

2001 • 40 citations

Benefits and risks of psychiatric medications during pregnancy.

2002 • 40 citations

Breastfeeding and risk of schizophrenia in the Copenhagen Perinatal Cohort

2005 • 39 citations

Neither the density nor function of striatal dopamine transporters were influenced by chronic n-3 polyunsaturated fatty acid deficiency in rodents

2002 • 38 citations

Brain abnormalities observed in childhood-onset schizophrenia: A review of the structural magnetic resonance imaging literature

2000 • 34 citations

Localization of mRNAs for Novel, Atypical As Well As Conventional Protein Kinase C (PKC) Isoforms in the Brain of Developing and Mature Rats

2000 • 34 citations

No association between breast-feeding and adult psychosis in two national birth cohorts

2000 • 34 citations

Attentional and neurocognitive characteristics of high-risk offspring of parents with schizophrenia compared with DSM-IV attention deficit hyperactivity disorder children

2005 • 34 citations

Essential fatty acids and maladjusted behaviour in children

1983 • 33 citations

Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia

1991 • 30 citations

Low birthweight in schizophrenia: prematurity or poor fetal growth?

2001 • 30 citations

Long-chain polyunsaturated fatty acid content in Dutch preterm breast milk; differences in the concentrations of docosahexaenoic acid and arachidonic acid due to length of gestation

1996 • 30 citations

The duration of breastfeeding and attention deficit hyperactivity disorder.

2005 • 29 citations

The effect of maternal smoking and ethanol on fatty acid transport by the human placenta

2002 • 28 citations

Type of feeding during infancy and later development of schizophrenia

2000 • 28 citations

Variation in [U-13C] α Linolenic Acid Absorption, β-oxidation and Conversion to Docosahexaenoic Acid in the Pre-Term Infant Fed a DHA-Enriched Formula

2006 • 25 citations

During neuronal and glial cell development diet n−6 to n−3 fatty acid ratio alters the fatty acid composition of phosphatidylinositol and phosphatidylserine

1997 • 25 citations

The effect of maternal smoking and ethanol on fatty acid transport by the human placenta

2002 • 25 citations

Maternal dietary fish oil enriches docosahexaenoate levels in brain subcellular fractions of offspring

1993 • 24 citations

Obstetric Complications Correlate with Neurobehavioral and Brain Structural Alterations in Young Relatives at Risk for Schizophrenia

2003 • 22 citations

Ultrastructural changes in brain parenchyma during normal aging and in animal models of aging

1994 • 22 citations

Can Breast-Feeding Protect against Schizophrenia?

2003 • 21 citations

Prenatal underdevelopment and schizophrenia: A case report of monozygotic twins

2003 • 21 citations

Response of Colonic Smooth Muscle from Newborn and Adult Rabbits to Electrical Field Stimulation

1994 • 18 citations

[Essential fatty acid content of maternal erythrocyte phospholipids. A study in preterm and full-term human newborns].

1998 • 15 citations

The myristoylated alanine-rich C kinase substrate: a lithium-regulated protein linking cellular signaling and cytoskeletal plasticity

2004 • 14 citations

Gray and White Matter Brain Volume in Aged Rats Raised onn-3 Fatty Acid Deficient Diets

2004 • 12 citations

THE USE OF A DIETARY SUPPLEMENT C OMBINATION AND AN ESSENTIAL FATTY ACID AS AN ALTERNATIVE AND COMPLEMENTARY T REATMENT FOR CHILDREN WITH ATTENTION -DEFICIT /H YPERACTIVITY DISORDER

2001 • 10 citations

Deleted Work

1955 • 0 citations