Omega-3 fatty acids and rodent behavior

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Mechanisms of action of docosahexaenoic acid in the nervous system

2001 • 909 citations

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

1993 • 690 citations

The Effects of Dietary α-Linolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats

1989 • 664 citations

Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain

1981 • 659 citations

The Essentiality Of N-3 Fatty Acids For The Development And Function Of The Retina And Brain

1988 • 621 citations

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

1998 • 580 citations

Neurobiology of Mental Illness

2011 • 532 citations

INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS

1983 • 527 citations

Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis

2002 • 514 citations

Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD)

2000 • 510 citations

Attention deficit/hyperactivity disorder--from brain dysfunctions to behaviour.

1998 • 490 citations

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival

2005 • 450 citations

Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

1999 • 446 citations

Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice

1998 • 441 citations

Behavioral Deficits Associated with Dietary Induction of Decreased Brain Docosahexaenoic Acid Concentration

2000 • 422 citations

Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals

2005 • 414 citations

Docosahexaenoic acid promotes neurite growth in hippocampal neurons

2004 • 398 citations

Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals

2005 • 392 citations

Dietary requirements and functions of α-linolenic acid in animals

1982 • 362 citations

Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

2002 • 358 citations

Neurobiology of Mental Illness.

2000 • 344 citations

Resolvins, docosatrienes, and neuroprotectins, novel omega‐3‐derived mediators, and their endogenous aspirin‐triggered epimers

2004 • 343 citations

Dietary essential fatty acids and brain function: a developmental perspective on mechanisms

2002 • 339 citations

Neuroprotectin D1 (NPD1): A DHA-Derived Mediator that Protects Brain and Retina Against Cell Injury-Induced Oxidative Stress

2006 • 336 citations

Biochemistry and physiology of n‐3 fatty acids

1992 • 321 citations

DOCOSAHEXAENOIC ACID: MEMBRANE FUNCTION AND METABOLISM

1986 • 319 citations

Chronic Dietary α-Linolenic Acid Deficiency Alters Dopaminergic and Serotoninergic Neurotransmission in Rats ,

1994 • 318 citations

Essentiality of fatty acids

1999 • 310 citations

Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression

2004 • 307 citations

Dietary fatty acids ? The n-6/n-3 balance and chronic elderly diseases. Excess linoleic acid and relative n-3 deficiency syndrome seen in Japan

1996 • 305 citations

Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats

1999 • 305 citations

Serotonin, stress and corticoids

2000 • 302 citations

Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)

2000 • 299 citations

Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats

2005 • 288 citations

Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats

1998 • 286 citations

The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study.

1996 • 283 citations

Omega-3 fatty acids in boys with behavior, learning, and health problems

1996 • 264 citations

Essential fatty acids and eicosanoids

1993 • 239 citations

One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats

2005 • 239 citations

Role of Serotonin in Depression^a

1990 • 239 citations

Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat

2004 • 236 citations

ALTERATION OF THE FATTY ACID COMPOSITION OF BRAIN LIPIDS BY VARYING LEVELS OF DIETARY ESSENTIAL FATTY ACJDS

1963 • 236 citations

Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response to n-3 Fatty Acid Deficiency

2004 • 231 citations

Effects of dietary fatty acids on the fatty acid composition of brain ethanolamine phosphoglyceride: Reciprocal replacement of n−6 and n−3 polyunsaturated fatty acids

1971 • 226 citations

Trial 2 in the elevated plus-maze: a different form of fear?

1993 • 217 citations

The dopamine mesocorticolimbic pathway is affected by deficiency in n−3 polyunsaturated fatty acids

2002 • 215 citations

Recovery of brain docosahexaenoate leads to recovery of spatial task performance

2003 • 210 citations

Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

2000 • 210 citations

Chronic Administration Of Docosahexaenoic Acid Improves The Performance Of Radial Arm Maze Task In Aged Rats

2001 • 204 citations

A new animal model of endogenous depression: A summary of present findings

1990 • 203 citations

Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory‐based and spatial learning tasks

1999 • 192 citations

Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum

2001 • 177 citations

Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions.

1988 • 176 citations

Do essential fatty acids play a role in brain and behavioral development?

1992 • 171 citations

Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio.

1993 • 166 citations

Cognitive deficits in docosahexaenoic acid-deficient rats.

2002 • 165 citations

Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status

2003 • 165 citations

Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression.

2003 • 164 citations

Polyunsaturated fatty acid status and neurodevelopment: A summary and critical analysis of the literature

1999 • 159 citations

Phospholipid supplementation reverses behavioral and biochemical alterations induced by n–3 polyunsaturated fatty acid deficiency in mice

2000 • 158 citations

Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids

2003 • 157 citations

Cognitive deficits in docosahexaenoic acid-deficient rats.

2002 • 156 citations

Effect of low intake of n−3 fatty acids during development on brain phospholipid fatty acid composition and exploratory behavior in rats

1991 • 155 citations

Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats

2005 • 151 citations

Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor

2001 • 150 citations

Polyunsaturated fatty acids of photoreceptor membranes

1974 • 147 citations

The nervous system has an absolute molecular species requirement for proper function

1995 • 141 citations

Reversibility of n-3 fatty acid deficiency-induced changes in dopaminergic neurotransmission in rats:critical role of developmental stage

2002 • 136 citations

Possible regulatory mechanism of DHA-induced anti-stress reaction in rats

2003 • 136 citations

Arachidonic Acid Offsets the Effects on Mouse Brain and Behavior of a Diet with a Low (n-6):(n-3) Ratio and Very High Levels of Docosahexaenoic Acid , ,

1997 • 133 citations

Long-Chain Polyunsaturated Fatty Acids

1998 • 132 citations

Dietary Fatty Acid Composition in Pregnancy Alters Neurite Membrane Fatty Acids and Dopamine in Newborn Rat Brain

2001 • 129 citations

Dietary intake of n-3, n-6 fatty acids and fish: Relationship with hostility in young adults—the CARDIA study

2003 • 128 citations

Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation

2003 • 125 citations

Linolenic acid deficiency: Changes in fatty acid patterns in female and male rats raised on a linolenic acid‐deficient diet for two generations

1978 • 124 citations

Can the physician diagnose hyperactivity in the office? (67:13–17, 1981)

1981 • 123 citations

Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice.

1993 • 123 citations

Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment

1999 • 123 citations

Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study

1998 • 115 citations

High maternal intake of polyunsaturated fatty acids during pregnancy in mice alters offsprings' aggressive behavior, immobility in the swim test, locomotor activity and brain protein kinase C activity.

1998 • 114 citations

Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. Part II

1997 • 113 citations

Olfactory discrimination deficits in n−3 fatty acid-deficient rats

2001 • 112 citations

Recovery of Altered Fatty Acid Composition Induced by a Diet Devoid of n‐3 Fatty Acids in Myelin, Synaptosomes, Mitochondria, and Microsomes of Developing Rat Brain

1986 • 110 citations

Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat

2002 • 109 citations

Docosahexaenoic Acid-rich Phospholipid Supplementation: Effect on Behavior, Learning Ability, and Retinal Function in Control and n-3 Polyunsaturated Fatty Acid Deficient Old Mice

2002 • 108 citations

The effect of docosahexaenoic acid on the electroretinogram of the guinea pig

1996 • 107 citations

Can Prenatal N-3 Fatty Acid Deficiency Be Completely Reversed after Birth? Effects on Retinal and Brain Biochemistry and Visual Function in Rhesus Monkeys

2005 • 103 citations

An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n‐6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance

2005 • 101 citations

Increased blood pressure later in life may be associated with perinatal n−3 fatty acid deficiency

2003 • 96 citations

Can the Physician Diagnose Hyperactivity in the Office?

1981 • 96 citations

N-3 Fatty Acid Deficiency Induced by a Modified Artificial Rearing Method Leads to Poorer Performance in Spatial Learning Tasks

2005 • 91 citations

Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice.

2000 • 85 citations

Issues of Design and Analysis Relating to the Use of Multiparous Species in Developmental Nutritional Studies

1998 • 85 citations

Effects of Fish Oil on the Central Nervous System: A New Potential Antidepressant?

2004 • 82 citations

Water Maze Performance Is Unaffected in Artificially Reared Rats Fed Diets Supplemented with Arachidonic Acid and Docosahexaenoic Acid

1999 • 81 citations

Dietary α-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM)

1995 • 78 citations

Effects of dietary alpha-linolenic acid deficiency on neuromuscular and cognitive functions in mice

1995 • 77 citations

Dietary α-Linolenic Acid at 1.3 g/kg Maintains Maximal Docosahexaenoic Acid Concentration in Brain, Heart and Liver of Adult Rats

1993 • 75 citations

Docosapentaenoic acid does not completely replace DHA in n−3 FA‐deficient rats during early development

2003 • 75 citations

Maternal Diet Fatty Acid Composition Affects Neurodevelopment in Rat Pups

1998 • 73 citations

Effects of a High-Linoleate and a High- -Linolenate Diet on the Learning Ability of Aged Rats Evidence Against an Autoxidation-Related Lipid Peroxide Theory of Aging

1991 • 71 citations

Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. I

1997 • 69 citations

Artificial rearing of infant rats on milk formula deficient in n‐3 essential fatty acids: A rapid method for the production of experimental n‐3 deficiency

1996 • 67 citations

Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus

2004 • 67 citations

DHA-Rich phospholipids optimize G-Protein–coupled signaling

2003 • 66 citations

Effect of dietary α-linolenic acid deficiency on habituation

1996 • 65 citations

Gene Expression Analysis in Human Fetal Retinal Explants Treated with Docosahexaenoic Acid

2003 • 63 citations

Fatty acids : physiological and behavioral functions

2001 • 62 citations

Odor matching and odor memory in the rat

1993 • 62 citations

Do Plasma Polyunsaturates Predict Hostility and Depression?

1997 • 56 citations

High-fat diet induces aggressive behavior in male mice and rats

1996 • 52 citations

Intraamniotic Ethyl Docosahexaenoate Administration Protects Fetal Rat Brain from Ischemic Stress

1998 • 51 citations

Brain Docosahexaenoic Acid Status and Learning in Young Rats Submitted to Dietary Long-Chain Polyunsaturated Fatty Acid Deficiency and Supplementation Limited to Lactation

2005 • 50 citations

Handbook of Essential Fatty Acid Biology

1997 • 49 citations

N–3 fatty acid deficiency in the rat pineal gland: effects on phospholipid molecular species composition and endogenous levels of melatonin and lipoxygenase products

1998 • 47 citations

Are ?3 Fatty Acids Essential Nutrients for Mammals?

2015 • 45 citations

The neurochemistry of schizophrenia

1994 • 41 citations

Effects of Dietary n-3 Fatty Acid Deficiency on Morris Water-Maze Performance and Amphetamine-Induced Conditioned Place Preference in Rats

1998 • 41 citations

A High Linoleate and a High .ALPHA.-Linolenate Diet Induced Changes in Learning Behavior of Rats. Effects of a Shift in Diets and Reversal of Training Stimuli.

1996 • 39 citations

Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching‐to‐place performance and response to dietary long‐chain polyunsaturated fatty acids

2003 • 39 citations

WKHA rats with genetic hyperactivity and hyperreactivity to stress: a review

2000 • 39 citations

Neither the density nor function of striatal dopamine transporters were influenced by chronic n-3 polyunsaturated fatty acid deficiency in rodents

2002 • 38 citations

Slow recovery of the fatty acid composition of sciatic nerve in rats fed a diet initially low in n−3 fatty acids

1987 • 35 citations

Nutrition and behaviour: the role of n-3 fatty acids in cognitive function.

2000 • 35 citations

Omega-3 Fatty Acid Deficiency and Behavior

1997 • 35 citations

A new prostaglandin, C22-PGF4α, synthesized from docosahexaenoic acid (C22:6n3) by trout gill

1981 • 35 citations

Increased arachidonic acid concentration in the brain of Flinders Sensitive Line rats, an animal model of depression

2005 • 34 citations

Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate

1990 • 33 citations

Nutritional (n-3) polyunsaturated fatty acids influence the behavioral responses to positive events in mice

2000 • 32 citations

α-Linolenic Acid Deficiency Modifies Distractibility but Not Anxiety and Locomotion in Rats during Aging

1998 • 28 citations

Method for hand-feeding mouse pups with nursing bottles.

2004 • 26 citations

Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice.

2002 • 26 citations

Docosahexaenoic Acid Accumulation in the Prenatal Brain: Prooxidant and Antioxidant Features

2001 • 25 citations

Nutrition and fitness in health and disease

1993 • 21 citations

Long‐term n‐3 FA deficiency modifies peroxisome proliferator‐activated receptor β mRNA abundance in rat ocular tissues

2002 • 21 citations

Effects of Essential Fatty Acid Preparation (SR-3) on Brain Lipids, Biochemistry, and Behavioral and Cognitive Functions

1997 • 21 citations

Cardiovascular Disease 2

1995 • 20 citations

Environmental temperature and the fatty acid compositions of house sparrow (Passer domesticus) muscle and brain

1977 • 17 citations

Lack of effect of eicosapentaenoic acid in the Porsolt forced swimming test model of depression

2002 • 16 citations

Phospholipids and fatty acid profile of brain synaptosomal membrane from normotensive and hypertensive rats

1987 • 15 citations

Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet

2005 • 15 citations

Omega-3 Fatty Acids and Psychiatric Disorders

2001 • 14 citations

Age-related changes in the retinal capillaries and the fatty acid composition of retinal tissue of normal and essential fatty acid-deficient rats.

1972 • 12 citations

Nutritional parameters modify muricidal behavior of male Wistar rats

2001 • 6 citations

Polyunsaturated fatty acids in the blood of spontaneously or induced muricidal male Wistar rats

2003 • 6 citations

Cardiovascular disease

1995 • 5 citations

Automatic feeder for newborn rat use within l2 hours of birth.

1996 • 4 citations

Biosynthesis of Docosanoids by Human Platelet: Cardiovascular Properties

1995 • 2 citations

What are the Consequences of a Deficiency in Brain and Retinal DHA?

2004 • 1 citations