The importance of the ratio of omega-6/omega-3 essential fatty acids
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References (96)
Atherosclerosis — An Inflammatory Disease
1999 • 21,494 citations
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
1994 • 7,068 citations
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
1999 • 3,818 citations
EFFECTS OF CHANGES IN FAT, FISH, AND FIBRE INTAKES ON DEATH AND MYOCARDIAL REINFARCTION: DIET AND REINFARCTION TRIAL (DART)
1989 • 2,639 citations
Omega-3 fatty acids in health and disease and in growth and development
1991 • 2,179 citations
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
1994 • 2,133 citations
The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
1989 • 1,951 citations
Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function
1985 • 1,344 citations
Paleolithic Nutrition
1985 • 1,310 citations
Omega 3 Fatty Acids in Bipolar Disorder
1999 • 815 citations
The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis
1993 • 772 citations
Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.
1993 • 709 citations
Stone agers in the fast lane: Chronic degenerative diseases in evolutionary perspective
1988 • 703 citations
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.
1992 • 585 citations
Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients
1998 • 580 citations
Health Effects of Polyunsaturated Fatty Acids in Seafoods
1986 • 565 citations
Fish-Oil Fatty Acid Supplementation in Active Rheumatoid Arthritis
1987 • 544 citations
Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4.
1997 • 543 citations
Airway Mucosal Inflammation Even in Patients with Newly Diagnosed Asthma
1993 • 543 citations
Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up.
1992 • 468 citations
Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids
1996 • 426 citations
Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids
1999 • 408 citations
Reduction in the Rate of Early Restenosis after Coronary Angioplasty by a Diet Supplemented with n–3 Fatty Acids
1988 • 385 citations
Effect on Blood Lipids and Haemostasis of a Supplement of Cod-Liver Oil, Rich in Eicosapentaenoic and Docosahexaenoic Acids, in Healthy Young Men
1981 • 359 citations
Lower serum high‐density lipoprotein cholesterol (HDL‐C) in major depression and in depressed men with serious suicidal attempts: relationship with immune‐inflammatory markers
1997 • 338 citations
Cretan Mediterranean diet for prevention of coronary heart disease
1995 • 337 citations
FATTY-ACID RATIOS IN FREE-LIVING AND DOMESTIC ANIMALS
1968 • 337 citations
Fats and Oils
1996 • 323 citations
Polyunsaturated fatty acids in the food chain in Europe
2000 • 298 citations
N‐3 and N‐6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case‐control study in Tours, France
2001 • 276 citations
Cereal Grains: Humanity�s Double-Edged Sword
1999 • 275 citations
Fish Oils Inhibit Endothelial Cell Production of Platelet-Derived Growth Factor-Like Protein
1988 • 274 citations
Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production
1997 • 271 citations
Common purslane: a source of omega-3 fatty acids and antioxidants.
1992 • 256 citations
Evolutionary aspects of omega-3 fatty acids in the food supply
1999 • 255 citations
n−3 fatty acids and human health: Defining strategies for public policy
2001 • 255 citations
Dietary n-3 fatty acids and therapy for rheumatoid arthritis
1997 • 247 citations
The effects of dietary ω-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers
1985 • 245 citations
The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina
1984 • 242 citations
Effect on Human Serum Lipids of Substituting Plant for Animal Fat in Diet.
1954 • 236 citations
Dietary Intake of Long-Chain Polyunsaturated Fatty Acids during the Paleolithic
1998 • 195 citations
A new era for science in nutrition
1987 • 193 citations
Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolemic and atherosclerotic porcine coronary arteries.
1988 • 187 citations
Polyunsaturated fatty acids in the food chain in Japan
2000 • 186 citations
Nutrition and Biochemistry of Trans and Positional Fatty Acid Isomers in Hydrogenated Oils
1984 • 182 citations
Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6.
1997 • 173 citations
Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects
1993 • 168 citations
Lower ratio of n-3 to n-6 fatty acids in cultured than in wild fish
1990 • 167 citations
New products from the agri‐food industry: The return of n‐3 fatty acids into the food supply
1999 • 152 citations
Omega-3 fatty acid content of the US food supply.
1992 • 152 citations
Trans-fatty acid intake in relation to serum lipid concentrations in adult men
1992 • 149 citations
Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits.
1994 • 148 citations
Evolutionary Aspects of Diet and Essential Fatty Acids
2000 • 146 citations
Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery.
1990 • 141 citations
Egg yolk as a source of long-chain polyunsaturated fatty acids in infant feeding
1992 • 139 citations
Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects
1992 • 138 citations
Enhancing effect of dietary supplementation with ω-3 fatty acids on plasma fibrinolysis in normal subjects
1985 • 131 citations
Differential Effects of Various Eicosanoids on the Production or Prevention of Arrhythmias in Cultured Neonatal Rat Cardiac Myocytes
1997 • 119 citations
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5
2002 • 116 citations
Overview of Evolutionary Aspects of ω3 Fatty Acids in the Diet
1998 • 114 citations
The analysis of polyunsaturated fatty acids in meat by capillary gas‐liquid chromatography
1982 • 110 citations
Handbook of Lipids in Human Nutrition
2020 • 108 citations
Adenoviral gene transfer of Caenorhabditis elegans n −3 fatty acid desaturase optimizes fatty acid composition in mammalian cells
2001 • 102 citations
Purslane in Human Nutrition and Its Potential for World Agriculture
2015 • 97 citations
Fatty Acid Ratios in Free-Living and Domestic Animals
2010 • 91 citations
SERUM-CHOLESTEROL RESPONSE TO DIETARY FAT
1957 • 90 citations
Significance of the N‐6/N‐3 Ratio for Insulin Action in Diabetes
1993 • 84 citations
Effects of Cod Liver Oil on Platelets and Coagulation in Familial Hypercholesterolemia (Type IIa)
1983 • 83 citations
Increased in vivo and in vitro platelet function in type II- and type IV-hyperlipoproteinemia
1979 • 82 citations
Dietary Supplementation with Low-Dose Fish Oils Lowers Fibrinogen Levels: A Randomized, Double-Blind Controlled Study
1989 • 80 citations
Is insulin resistance influenced by dietary linoleic acid and trans fatty acids?
1994 • 80 citations
Modified Cretan Mediterranean Diet in the Prevention of Coronary Heart Disease and Cancer
2000 • 79 citations
The Role of Fatty Acids in Gene Expression: Health Implications
1996 • 75 citations
Linoleic acid and linolenic acid elongation products in muscle tissue of Syncerus caffer and other ruminant species
1969 • 73 citations
MISSING ANTI-PROLIFERATIVE EFFECT OF FISH OIL ON RECTAL EPITHELIUM IN HEALTHY VOLUNTEERS CONSUMING A HIGH-FAT DIET
1995 • 66 citations
Genetic Variation and Evolutionary Aspects of Diet
2019 • 60 citations
Genetic Variation and Nutrition
1999 • 58 citations
Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells.
2002 • 54 citations
The Omega Diet: The Lifesaving Nutritional Program Based on the Diet of the Island of Crete
1999 • 46 citations
Obesity: new directions in assessment and management
1996 • 44 citations
EFFECTS OF OMEGA–3 FATTY ACIDS ON THE GENERATION OF PRODUCTS OF THE 5-LIPOXYGENASE PATHWAY11Supported by grants AI-00399, AI-22563, AI-23401, AI-22531, AM-35907, and HL-36110 from the National Institutes of Health.
1986 • 40 citations
Omega-3 Fatty Acids in Major Depression
2001 • 39 citations
Plants in human nutrition
1995 • 38 citations
The return of ω3 fatty acids into the food supply. 1. Land-based animal food products and their health effects.
1998 • 35 citations
Fish and fish oil intake: Effect on haematological variables related to cardiovascular disease
1991 • 35 citations
Evolutionary Aspects of Nutrition and Health
1999 • 32 citations
The Mediterranean Food Guide
1995 • 31 citations
Omega‐6/Omega‐3 Fatty Acid Ratio and Trans Fatty Acids in Non‐Insulin‐dependent Diabetes Mellitus
1997 • 30 citations
Fatty Acid Composition of Skeletal Muscle Membrane Phospholipids, Insulin Resistance and Obesity
1994 • 27 citations
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2
1997 • 26 citations
Genetic Variation and Dietary Response
2001 • 24 citations
Different Doses of Fish — Oil Fatty Acid Ingestion in Active Rheumatoid Arthritis: A Prospective Study of Clinical and Immunological Parameters
1989 • 19 citations
The Return of w3 Fatty Acids into the Food Supply
1998 • 15 citations
Omega-3 Fatty Acids from Vegetable Oils
1989 • 14 citations
Are we what we eat?
1978 • 7 citations
Antioxidants, nutrition and health
2002 • 4 citations