Imaging the Effects of Methylphenidate on Brain Dopamine: New Model on Its Therapeutic Actions for Attention-Deficit/Hyperactivity Disorder

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Dopamine neurons report an error in the temporal prediction of reward during learning

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Association of attention-deficit disorder and the dopamine transporter gene.

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Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core

2001 • 908 citations

Practice Parameter for the Use of Stimulant Medications in the Treatment of Children, Adolescents, and Adults

2002 • 907 citations

Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate

1998 • 878 citations

Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop

1999 • 858 citations

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

2000 • 760 citations

Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain

2001 • 745 citations

Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration

1998 • 686 citations

Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.

1996 • 684 citations

Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine

1997 • 613 citations

Attention-deficit hyperactivity disorder and hyperkinetic disorder

1998 • 582 citations

Is Methylphenidate Like Cocaine?

1995 • 575 citations

Attention-deficit hyperactivity disorder and hyperkinetic disorder

2001 • 567 citations

Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography

2000 • 517 citations

Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism

1997 • 498 citations

Association and Linkage of the Dopamine Transporter Gene and Attention-Deficit Hyperactivity Disorder in Children: Heterogeneity owing to Diagnostic Subtype and Severity

1998 • 467 citations

“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect

2002 • 447 citations

Toward a Pathophysiology of Attention-Deficit/Hyperactivint Disorder

1997 • 399 citations

Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach

1998 • 383 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

Brain Imaging of Attention Deficit/Hyperactivity Disorder

2001 • 332 citations

DOPA Decarboxylase Activity in Attention Deficit Hyperactivity Disorder Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study

1998 • 320 citations

Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry

2000 • 320 citations

Side Effects of Methylphenidate and Dexamphetamine in Children With Attention Deficit Hyperactivity Disorder: A Double-blind, Crossover Trial

1997 • 301 citations

Evidence That Methylphenidate Enhances the Saliency of a Mathematical Task by Increasing Dopamine in the Human Brain

2004 • 269 citations

Anti-hyperactivity medication: methylphenidate and amphetamine

1998 • 262 citations

Stimulant Medications

1999 • 259 citations

High Midbrain [¹⁸F]DOPA Accumulation in Children With Attention Deficit Hyperactivity Disorder

1999 • 252 citations

Dopaminergic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats

1996 • 245 citations

Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder

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Preliminary Normative Data on DSM-IV Attention Deficit Hyperactivity Disorder in College Students

1998 • 216 citations

A neuropsychological examination of the underlying deficit in attention deficit hyperactivity disorder: Frontal lobe versus right parietal lobe theories.

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Hedonic valence, dopamine and motivation.

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Pharmacology of the enantiomers of threo-methylphenidate.

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Behavior-Relevant Changes in Nucleus Accumbens Dopamine Transmission Elicited by Food Reinforcement: An Electrochemical Study in Rat

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Chiral drugs: comparison of the pharmacokinetics of [ 11 C] d-threo and l-threo -methylphenidate in the human and baboon brain

1997 • 153 citations

Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking

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Unaltered Dopamine Transporter Availability in Adult Attention Deficit Hyperactivity Disorder

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Effects of Stimulant Medication on Learning in Children with ADHD

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Cerebrospinal Fluid Homovanillic Acid Predicts Behavioral Response to Stimulants in 45 Boys with Attention Deficit/Hyperactivity Disorder

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A Naturalistic Assessment of the Motor Activity of Hyperactive Boys

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Adult attention-deficit/hyperactivity disorder: Neuropsychological correlates and clinical presentation

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Efficacy of a New Pattern of Delivery of Methylphenidate for the Treatment of ADHD: Effects on Activity Level in the Classroom and on the Playground

2002 • 99 citations

Objective and subjective measures of the pharmacodynamic effects of Adderall in the treatment of children with ADHD in a controlled laboratory classroom setting.

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Is increased D2 receptor availability associated with response to stimulant medication in ADHD

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Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex

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The Mechanism of Action of Drugs Used to Treat Attention-Deficit Hyperactivity Disorder: Focus on Catecholamine Receptor Pharmacology

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Regulation of substantia nigra dopamine neurons.

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Side effects of dextroamphetamine and methylphenidate in hyperactive children — A brief review

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THE EFFECT OF DEXEDRINE ON RAPID DISCRIMINATION AND MOTOR CONTROL OF HYPERKINETIC CHILDREN UNDER MILD STRESS

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Effects of methylphenidate on responding under extinction in the presence and absence of conditioned reinforcement

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Neuroimaging in hyperkinetic children and adults: an overview

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Amphetamine anorexia in cats: the effect of encouraging to ingestive behavior.

1985 • 2 citations

Deleted Work

1955 • 0 citations