Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Telomere states and cell fates

2000 • 1,359 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

Apoptosis and disease

1993 • 684 citations

A Mammalian Telomerase-Associated Protein

1997 • 656 citations

Regulators of cell death

1995 • 647 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

2003 • 435 citations

Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

2004 • 370 citations

Involvement of 14-3-3 proteins in nuclear localization of telomerase

2000 • 320 citations

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

2000 • 304 citations

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

2001 • 285 citations

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

2000 • 257 citations

Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

2003 • 256 citations

Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells

1999 • 249 citations

hTERT associates with human telomeres and enhances genomic stability and DNA repair

2003 • 242 citations

Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation

2001 • 235 citations

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

1995 • 210 citations

The Catalytic Subunit of Telomerase Is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function

2000 • 189 citations

The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

2000 • 174 citations

Telomere Dysfunction Triggers Developmentally Regulated Germ Cell Apoptosis

2001 • 161 citations

A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.

2000 • 156 citations

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis

1998 • 155 citations

Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins

2001 • 150 citations

Bcl-2 Modulates Telomerase Activity

1997 • 149 citations

Bcl‐2 overexpression enhances the metastatic potential of a human breast cancer line

1997 • 142 citations

Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells.

2003 • 133 citations

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

2003 • 128 citations

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.

2001 • 117 citations

Bcl-2 Prevents CD95 (Fas/APO-1)-induced Degradation of Lamin B and Poly(ADP-ribose) Polymerase and Restores the NF-κB Signaling Pathway

1996 • 107 citations

Bcl-2 expression regulates sodium butyrate-induced apoptosis in human MCF-7 breast cancer cells.

1996 • 101 citations

bcl-2 over-expression enhances NF-?B activity and induces mmp-9 transcription in human MCF7ADR breast-cancer cells

2000 • 97 citations

Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells

2001 • 96 citations

Mechanisms of Telomerase Induction During Vascular Smooth Muscle Cell Proliferation

2001 • 82 citations

Methionine Aminopeptidase-2 Regulates Human Mesothelioma Cell Survival

2001 • 82 citations

C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells

2001 • 79 citations

Emerging roles for telomerase in neuronal development and apoptosis

2001 • 77 citations

Expression of telomerase inhibits hydroxyl radical‐induced apoptosis in normal telomerase negative human lung fibroblasts

2001 • 76 citations

Inhibition of telomerase activity in human cancer cells by RNA interference.

2003 • 74 citations

Telomerase, checkpoints and cancer.

1997 • 72 citations

bcl-2 Induction of Urokinase Plasminogen Activator Receptor Expression in Human Cancer Cells through Sp1 Activation

2004 • 65 citations

Telomerase protects developing neurons against DNA damage-induced cell death

2001 • 63 citations

Glutathione Depletion Induced by c-Myc Downregulation Triggers Apoptosis on Treatment with Alkylating Agents

2004 • 54 citations

Glutathione Depletion Induced by c-Myc Downregulation Triggers Apoptosis on Treatment with Alkylating Agents

2004 • 53 citations

Glutathione Influences c-Myc-induced Apoptosis in M14 Human Melanoma Cells

2002 • 49 citations

Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones

2002 • 27 citations