The Catalytic Subunit of Telomerase Protects Neurons Against Amyloid β‐Peptide‐Induced Apoptosis

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

1997 • 1,252 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

1997 • 913 citations

Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

1998 • 874 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1997 • 488 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2

1999 • 479 citations

Human telomerase contains evolutionarily conserved catalytic and structural subunits

1997 • 476 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

1997 • 440 citations

Telomerase activity, cell proliferation, and cancer

1998 • 402 citations

Telomeres, Telomerase, and Immortality

1995 • 393 citations

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

1997 • 386 citations

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

1999 • 384 citations

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1999 • 384 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Effects of Reverse Transcriptase Inhibitors on Telomere Length and Telomerase Activity in Two Immortalized Human Cell Lines

1996 • 337 citations

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

1998 • 332 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors

1998 • 303 citations

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

1997 • 300 citations

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1998 • 269 citations

Differentiation of immortal cells inhibits telomerase activity.

1995 • 269 citations

Studies of the molecular mechanisms in the regulation of telomerase activity

1999 • 255 citations

Amyloid β-peptide induces apoptosis-related events in synapses and dendrites

1998 • 254 citations

Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells

1999 • 249 citations

Increased Vulnerability of Hippocampal Neurons from Presenilin‐1 Mutant Knock‐In Mice to Amyloid β‐Peptide Tox

1999 • 195 citations

The Catalytic Subunit of Telomerase Is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function

2000 • 189 citations

DNA damage, mutation and fine structure DNA repair in aging

1995 • 176 citations

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain

1997 • 175 citations

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

1997 • 169 citations

DNA strand breaks in Alzheimer's disease

1999 • 166 citations

Caspase Dependent DNA Fragmentation Might Be Associated with Excitotoxicity in Alzheimer Disease

1998 • 155 citations

Cell death induced by β-amyloid 1–40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

1995 • 137 citations

Evidence for caspase‐mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

1999 • 132 citations

Poly(ADP‐Ribose) Synthetase Activation: An Early Indicator of Neurotoxic DNA Damage

1995 • 118 citations

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.

1996 • 113 citations

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

1999 • 110 citations

Bcl-2 Facilitates Recovery from DNA Damage after Oxidative Stress

1999 • 96 citations

Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro

1999 • 90 citations

Irreversible Telomere Shortening by 3′-Azido-2′, 3′-Dideoxythymidine (AZT) Treatment

1998 • 85 citations

Bcl-2 and Bax protein expression in Alzheimer's disease

1998 • 77 citations

Reverse transcriptase inhibitors suppress telomerase function and induce senescence‐like processes in cultured mouse fibroblasts

1996 • 72 citations

Inhibition of telomerase activity and cell proliferation by a reverse transcriptase inhibitor in gynaecological cancer cell lines

1999 • 68 citations

Induction of apoptosis by human amylin in RINm5F islet β‐cells is associated with enhanced expression of p53 and p21^WAF1/CIP1

1999 • 63 citations

GADD45Is Induced in Alzheimer's Disease, and Protects against Apoptosisin Vitro

1998 • 63 citations

Downregulation of telomerase activity in HL60 cells by differentiating agents is accompanied by increased expression of telomerase-associated protein

1997 • 42 citations