Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance

Mitochondria and Apoptosis

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Death Receptors: Signaling and Modulation

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Identification of a specific telomere terminal transferase activity in tetrahymena extracts

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hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

The Receptor for the Cytotoxic Ligand TRAIL

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Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

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The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

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Inhibition of telomerase limits the growth of human cancer cells

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Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

2002 • 427 citations

Natural and pharmacological regulation of telomerase

2002 • 347 citations

Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells

1999 • 249 citations

Expression of Human Telomerase (hTERT) Does Not Prevent Stress-induced Senescence in Normal Human Fibroblasts but Protects the Cells from Stress-induced Apoptosis and Necrosis

2002 • 248 citations

Cell death: TRAIL and its receptors

1997 • 196 citations

The Catalytic Subunit of Telomerase Is Expressed in Developing Brain Neurons and Serves a Cell Survival-Promoting Function

2000 • 189 citations

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis

1998 • 155 citations

Telomerase regulation: not just flipping the switch

2002 • 150 citations

Telomerase and chromosome end maintenance

1998 • 118 citations

Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.

1994 • 111 citations

Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation

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Reversible Manipulation of Telomerase Expression and Telomere Length

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NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

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2-5A Antisense Directed against Telomerase RNA Produces Apoptosis in Ovarian Cancer Cells

2000 • 71 citations

Telomerase protects developing neurons against DNA damage-induced cell death

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Telomerase and Telomeres: From Basic Biology to Cancer Treatment

2002 • 37 citations

Inhibition of telomerase activity with hTERT antisense increases the effect of CDDP-induced apoptosis in myeloid leukemia

2002 • 29 citations

Attenuation of telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents

2000 • 25 citations

A novel mechanism of retinoic acid resistance in acute promyelocytic leukemia cells through a defective pathway in telomerase regulation

2002 • 23 citations