DNA supercoiling suppresses real-time PCR: a new approach to the quantification of mitochondrial DNA damage and repair

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

2002 • 7,125 citations

Real time quantitative PCR.

1996 • 6,155 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

2000 • 3,871 citations

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

2005 • 3,020 citations

Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions

1993 • 2,177 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.

1967 • 1,317 citations

Replication of animal mitochondrial DNA

1982 • 1,221 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Changes in Mitochondrial DNA as a Marker of Nucleoside Toxicity in HIV-Infected Patients

2002 • 572 citations

Mitochondrial DNA in human malignancy

2001 • 438 citations

Prostate carcinogenesis and inflammation: emerging insights

2004 • 385 citations

Escherichia coli DNA topoisomerase I mutants: Increased supercoiling is corrected by mutations near gyrase genes

1982 • 376 citations

Oxidative damage to mitochondrial DNA and its relationship to ageing

1995 • 350 citations

Mitochondrial DNA repair and aging

2002 • 340 citations

Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats

2002 • 337 citations

Transcription and replication of mitochondrial DNA

2000 • 307 citations

Oxidative Stress-related Alteration of the Copy Number of Mitochondrial DNA in Human Leukocytes

2003 • 274 citations

Analysis of Gene-Specific DNA Damage and Repair Using Quantitative Polymerase Chain Reaction

2000 • 255 citations

Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates.

2001 • 245 citations

Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death

2003 • 205 citations

Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations

2003 • 180 citations

Evidence for mitochondrial DNA damage by lipid peroxidation

1988 • 160 citations

Measuring Oxidative mtDNA Damage and Repair Using Quantitative PCR

2003 • 157 citations

Mitochondrial proteome: Altered cytochrome c oxidase subunit levels in prostate cancer

2003 • 153 citations

Replication of Mitochondrial DNA in Mouse L Cells and Their Thymidine Kinase ^- Derivatives: Displacement Replication on a Covalently-Closed Circular Template

1972 • 134 citations

Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

1991 • 131 citations

DNA topoisomerase I mutants

1985 • 131 citations

Cancer-related changes in prostate DNA as men age and early identification of metastasis in primary prostate tumors

2003 • 123 citations

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance

2005 • 112 citations

Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissection.

2002 • 110 citations

Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in Myoclonus Epilepsy and Ragged-Red Fibers (MERRF) syndrome by a multiplex Molecular Beacon based real-time fluorescence PCR

2001 • 93 citations

Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA

1997 • 80 citations

Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reaction

2001 • 76 citations

Quantification of human mitochondrial DNA in a real time PCR

2002 • 70 citations

Somatic Mitochondrial DNA Mutations in Prostate Cancer and Normal Appearing Adjacent Glands in Comparison to Age-Matched Prostate Samples without Malignant Histology

2006 • 68 citations

Base excision repair of mitochondrial DNA damage in mammalian cells

2001 • 63 citations

Metal ion-dependent hydrogen peroxide-induced DNA damage is more sequence specific than metal specific.

1997 • 54 citations

Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis

2003 • 47 citations

Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas

2004 • 44 citations

Ascorbate/iron mediation of hydroxyl free radical damage to PBR322 plasmid DNA

1988 • 43 citations

Mechanism of mitochondrial DNA replication in mouse L-cells: Introduction of superhelical turns into newly replicated molecules

1978 • 42 citations

Mitochondrial dna damage by bleomycin

1987 • 38 citations

Mitochondrial Mutagenesis and Oxidative Stress in Human Prostate Cancer

2004 • 35 citations

Comparison of iron‐catalyzed DNA and lipid oxidation

2001 • 29 citations

A method for assessing damage to mitochondrial DNA caused by radiation and epichlorohydrin.

1985 • 28 citations

Direct observation of iron-induced conformational changes of mitochondrial DNA by high-resolution field-emission in-lens scanning electron microscopy.

1996 • 26 citations

DNA Enzymology above 100 °C.

1995 • 22 citations

Iron Ion Induces Mitochondrial DNA Damage in HTC Rat Hepatoma Cell Culture-Role of Antioxidants in Mitochondrial DNA Protection from Oxidative Stresses

1994 • 22 citations

Iron(II) induces changes in the conformation of mammalian mitochondrial DNA resulting in a reduction of its transcriptional rate

2000 • 17 citations

Kinetics of phosphate-mediated oxidation of ferrous iron and formation of 8-oxo-2′-deoxyguanosine in solutions of free 2′-deoxyguanosine and calf thymus DNA

2002 • 10 citations