Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Diabetic Nephropathy: Diagnosis, Prevention, and Treatment

2005 • 1,717 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Selectins and their ligands: current concepts and controversies

1996 • 1,446 citations

Preserving renal function in adults with hypertension and diabetes: A consensus approach

2000 • 1,406 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

1999 • 1,228 citations

Structural-functional relationships in diabetic nephropathy.

1984 • 1,202 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Diabetic nephropathy in type 1 (insulin-dependent) diabetes: An epidemiological study

1983 • 1,078 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Mouse Models of Diabetic Nephropathy

2009 • 865 citations

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 • 835 citations

Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

2001 • 801 citations

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

2003 • 798 citations

Oxidative damage to DNA in diabetes mellitus

1996 • 789 citations

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

2003 • 784 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

2003 • 563 citations

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

2001 • 561 citations

Inflammatory Chemokine Transport and Presentation in HEV

2001 • 532 citations

Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE

2002 • 525 citations

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury

2003 • 518 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

CD99 plays a major role in the migration of monocytes through endothelial junctions

2002 • 497 citations

Chemokines, Chemokine Receptors, and Renal Disease

2000 • 492 citations

Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18

1996 • 484 citations

Diabetic kidney disease in thedb/dbmouse

2003 • 479 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

Glycosylated Hemoglobin and the Risk of Microalbuminuria in Patients with Insulin-Dependent Diabetes Mellitus

1995 • 460 citations

Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

2004 • 445 citations

The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

2000 • 420 citations

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

2005 • 405 citations

Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes

2000 • 372 citations

Racial Differences in Diabetic Nephropathy, Cardiovascular Disease, and Mortality in a National Population of Veterans

2003 • 352 citations

New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology

2004 • 345 citations

Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy

2000 • 337 citations

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

2000 • 327 citations

Transcriptional Regulation of The Human Monocyte Chemoattractant Protein-1 Gene

1997 • 317 citations

The Role of Macrophages in Diabetic Glomerulosclerosis

1993 • 312 citations

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

1996 • 311 citations

The Neutrophil: Function and Regulation in Innate and Humoral Immunity

2001 • 304 citations

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

2003 • 293 citations

The Pathogenesis of Chronic Renal Failure in Diabetic Nephropathy

1991 • 284 citations

Glomerular Lesions and Urinary Albumin Excretion in Type I Diabetes without Overt Proteinuria

1989 • 280 citations

Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo.

1998 • 277 citations

Diabetes-Induced Oxidative Stress and Low-Grade Inflammation in Porcine Coronary Arteries

2003 • 274 citations

Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice

2005 • 267 citations

Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis

1999 • 265 citations

Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells.

1996 • 265 citations

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

2001 • 263 citations

Are changes in integrin affinity and conformation overemphasized?

1998 • 257 citations

Mouse models of insulin dependent diabetes: Low‐dose streptozocin‐induced diabetes and nonobese diabetic (NOD) mice

1987 • 246 citations

Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy.

1991 • 243 citations

L-Selectin Shedding Regulates Leukocyte Recruitment

2001 • 221 citations

Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP‐1)

1996 • 205 citations

Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells.

1992 • 203 citations

Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction

2004 • 196 citations

Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis

2004 • 190 citations

CD44 is a physiological E-selectin ligand on neutrophils

2005 • 189 citations

Increased Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Diabetic Rat Glomeruli: Glomerular Hyperfiltration Is a Potential Mechanism of ICAM-1 Upregulation

1997 • 187 citations

Mechanisms contributing to the activity of integrins on leukocytes

2002 • 181 citations

ACE Inhibitors Improve Diabetic Nephropathy Through Suppression of Renal MCP-1

2003 • 179 citations

Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus

1982 • 177 citations

PSGL-1 participates in E-selectin–mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and α4 integrin

2003 • 174 citations

Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy

2002 • 173 citations

Nephron Number and Renal Risk in Hypertension and Diabetes

2005 • 160 citations

Migration of CX3CR1‐positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis

2002 • 155 citations

Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation

2003 • 152 citations

The role of macrophages in glomerulonephritis

2001 • 151 citations

Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease

2002 • 151 citations

Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts

2005 • 148 citations

β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo

1998 • 147 citations

Evidence That Glucose Increases Monocyte Binding to Human Aortic Endothelial Cells

1994 • 145 citations

High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-ϰB-dependent

2000 • 139 citations

Accelerated Nephropathy in Diabetic Apolipoprotein E-Knockout Mouse

2004 • 137 citations

CXCR2- and E-Selectin–induced Neutrophil Arrest during Inflammation In Vivo

2004 • 135 citations

Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption

2005 • 131 citations

Advanced glycosylation endproduct-specific receptors on human and rat T-lymphocytes mediate synthesis of interferon gamma: role in tissue remodeling.

1993 • 125 citations

P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions.

1997 • 125 citations

Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.

1995 • 125 citations

Expression of Functional CCR and CXCR Chemokine Receptors in Podocytes

2002 • 122 citations

Regulation of endothelial cell contacts during leukocyte extravasation

2002 • 122 citations

Unchanged Incidence of Diabetic Nephropathy in IDDM Patients

1995 • 120 citations

Endothelial dysfunction in diabetic nephropathy: state of the art and potential significance for non-diabetic renal disease

2004 • 120 citations

Animal models of spontaneous diabetic kidney disease

1990 • 119 citations

Structure and Function of P-Selectin Glycoprotein Ligand-1

1998 • 115 citations

Cytokines and mesangial cells.

1993 • 115 citations

Human renal tubular cells as a cytokine source: PDGF-B, GM-CSF and IL-6 mRNA expression in vitro.

1993 • 111 citations

Increased expression of selectins in kidneys of patients with diabetic nephropathy

1998 • 111 citations

Pathophysiology of cardiovascular damage in the early renal population

2001 • 110 citations

Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice

1998 • 104 citations

A High Glucose Concentration Stimulates the Expression of Monocyte Chemotactic Peptide 1 in Human Mesangial Cells

1998 • 100 citations

Differential selectivity of insulin secretagogues

2003 • 93 citations

Diabetic nephropathy: Fault or destiny?

1981 • 93 citations

Interleukin-1β stimulates human renal fibroblast proliferation and matrix protein production by means of a transforming growth factor-β-dependent mechanism

2002 • 91 citations

Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils

1997 • 90 citations

Strain differences rather than hyperglycemia determine the severity of glomerulosclerosis in mice

1998 • 90 citations

Effect of retinoic acid in experimental diabetic nephropathy

2004 • 89 citations

A functional role for osteopontin in experimental crescentic glomerulonephritis in the rat.

1998 • 87 citations

Gene transfer of RANTES elicits autoimmune renal injury in MRL-Faslpr mice

1998 • 86 citations

Mitogenic effect of platelet-derived growth factor in human glomerular mesangial cells: modulation and/or suppression by inflammatory cytokines

1991 • 83 citations

Streptozotocin-induced diabetic nephropathy in rats: The role of inflammatory cytokines

2005 • 77 citations

Mechanisms of glomerular macrophage infiltration in lipid-induced renal injury

1999 • 74 citations

Phosphorylation of the Cytoplasmic Domain of E-Selectin Is Regulated During Leukocyte-Endothelial Adhesion

1998 • 68 citations

Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB-Lepr db ) and obese (DBA-Lep ob ) mice

2002 • 66 citations

Macrophages promote prosclerotic responses in cultured rat mesangial cells

1997 • 64 citations

Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion

2002 • 63 citations

Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia.

1990 • 62 citations

High insulin exacerbates neutrophil-endothelial cell adhesion through endothelial surface expression of intercellular adhesion molecule-1 via activation of protein kinase C and mitogen-activated protein kinase

2002 • 62 citations

Juxtaglomerular apparatus T-cell infiltration affects glomerular structure in Type 1 diabetic patients

2004 • 61 citations

Suppression of experimental glomerulonephritis by the interleukin-1 receptor antagonist

1994 • 60 citations

Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines

2002 • 59 citations

Radical scavenging effect of gliclazide in diabetic rats fed with a high cholesterol diet

2004 • 56 citations

Proteinuria and Activated T-Lymphocytes in Diabetic Nephropathy

1988 • 54 citations

Cardiovascular morbidity and early mortality cluster in parents of type 1 diabetic patients with diabetic nephropathy.

2000 • 53 citations

Expression of ICAM-1 on glomeruli is associated with progression of diabetic nephropathy in a genetically obese diabetic rat, Wistar fatty

1996 • 50 citations

The Role of Selectins in Glomerular Leukocyte Recruitment in Rat Anti-Glomerular Basement Membrane Glomerulonephritis

1999 • 48 citations

Fractalkine and Its Receptor, CX3CR1, Upregulation in Streptozotocin-Induced Diabetic Kidneys

2004 • 46 citations

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms

2005 • 45 citations

Renal Lesions in Spontaneous Insulin-dependent Diabetes Mellitus in the Nonobese Diabetic Mouse: Acute Phase of Diabetes

2003 • 40 citations

Renal Function and Glucose Transport in Male and Female Mice with Diet-Induced Type II Diabetes Mellitus

2000 • 39 citations

The Influence of Genetic Background on the Susceptibility of Inbred Mice to Streptozotocin-induced Diabetes

1984 • 34 citations

Regulation of Function and Expression of P-Selectin

1995 • 29 citations

Differing roles of CD18 and VLA-4 in leukocyte migration/activation during anti-GBM nephritis

1996 • 28 citations

Increased secretion of TGF‐β1 by peripheral blood mononuclear cells from patients with Type 1 diabetes mellitus with diabetic nephropathy

2001 • 28 citations

Cyclooxygenase inhibition enhances rat interleukin 1 beta-induced growth of rat mesangial cells in culture

1990 • 26 citations

Histopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice

1986 • 24 citations

Unique Glomerular Lesion with Spontaneous Lipid Deposition in Glomerular Capillary Lumina in the NON Strain of Mice

1991 • 22 citations

The functions of circulatory polymorphonuclear leukocytes in diabetic patients with and without diabetic triopathy

2000 • 22 citations

Production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with diabetic nephropathy

1993 • 21 citations

Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy

2002 • 19 citations

Ligands for l-selectin: where and how many?

1993 • 13 citations

Production of superoxide anion by polymorphonuclear leukocytes from diabetic patients with or without diabetic retinopathy

1995 • 13 citations

Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.

1988 • 12 citations

Deleted Work

1955 • 0 citations