Grb3-3 Is Up-regulated in HIV-1-infected T-cells and Can Potentiate Cell Activation through NFATc

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

LAT

1998 • 1,251 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

LAT Palmitoylation

1998 • 837 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Multifaceted Activities of the HIV-1 Transactivator of Transcription, Tat

1999 • 411 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis

1993 • 368 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells

1997 • 313 citations

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

1998 • 306 citations

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

2000 • 269 citations

Adaptors and Molecular Scaffolds in Immune Cell Signaling

1999 • 222 citations

Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells

1998 • 221 citations

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

1997 • 215 citations

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1997 • 206 citations

ERK MAP Kinase Links Cytokine Signals to Activation of Latent HIV-1 Infection by Stimulating a Cooperative Interaction of AP-1 and NF-κB

1999 • 202 citations

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

1995 • 199 citations

Binding of Human Immunodeficiency Virus Type 1 to CD4 and CXCR4 Receptors Differentially Regulates Expression of Inflammatory Genes and Activates the MEK/ERK Signaling Pathway

1998 • 183 citations

The GRB2/Sem‐5 adaptor protein

1994 • 182 citations

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1999 • 180 citations

Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV.

1986 • 162 citations

HIV-1 Production from Infected Peripheral Blood T Cells After HTLV-I Induced Mitogenic Stimulation

1988 • 157 citations

Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase

1998 • 156 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1996 • 134 citations

Signal transduction in T lymphocytes using a conditional allele of Sos.

1995 • 131 citations

Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi’s Sarcoma Cells

1998 • 118 citations

HIV-Tat Protein Activates c-Jun N-Terminal Kinase and Activator Protein-1

1998 • 116 citations

Synergistic Activation of NFAT by HIV-1 Nef and the Ras/MAPK Pathway

2000 • 112 citations

Tat protein induces self-perpetuating permissivity for productive HIV-1 infection

1997 • 111 citations

Cloning of a Grb2 Isoform with Apoptotic Properties

1994 • 91 citations

Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes.

1996 • 86 citations

Reciprocal Modulatory Interaction between Human Immunodeficiency Virus Type 1 Tat and Transcription Factor NFAT1

1999 • 72 citations

Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors.

1998 • 66 citations

NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction

1995 • 66 citations

Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both Hck and MAPK signaling events 1 1Edited by J. Karn

1999 • 63 citations

Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus

1997 • 58 citations

Signaling mechanisms in T cells.

1991 • 53 citations

Involvement of Extracellular Signal-Regulated Kinase Module in HIV-Mediated CD4 Signals Controlling Activation of Nuclear Factor-κB and AP-1 Transcription Factors

1998 • 51 citations

Grb2 Interaction with MEK-Kinase 1 Is Involved in Regulation of Jun-Kinase Activities in Response to Epidermal Growth Factor

1998 • 49 citations

The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B

1996 • 45 citations

Human Immunodeficiency Virus Type-1 TAT Enhances Interleukin-2 Promoter Activity Through Synergism with Phorbol Ester and Calcium-Mediated Activation of the NF-AT cis-Regulatory Motif

1994 • 39 citations

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1

1997 • 24 citations