Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 872 citations

Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy

1993 • 803 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

1996 • 571 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

Lack of Evidence for the Dichotomy of T_H1 and T_H2 Predominance in HIV-Infected Individuals

1994 • 434 citations

Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes

1988 • 397 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

1992 • 353 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1995 • 229 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells

1994 • 184 citations

Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts.

1994 • 177 citations

HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines.

1995 • 144 citations

Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.

1996 • 136 citations

A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1

1994 • 77 citations

Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.

1994 • 67 citations

Suppression of interleukin-2 and interleukin-2 receptor expression in jurkat cells stably expressing the human immunodeficiency virus tat protein

1992 • 65 citations

Constitutive Expression of Human Immunodeficiency Virus Type 1tatGene Inhibits Interleukin 2 and Interleukin 2 Receptor Expression in a Human CD4⁺T Lymphoid (H9) Cell Line

1995 • 44 citations

Costimulation of T-cell activation and virus production by B7 antigen on activated CD4+ T cells from human immunodeficiency virus type 1-infected donors.

1993 • 44 citations

Human Immunodeficiency Virus Type-1 TAT Enhances Interleukin-2 Promoter Activity Through Synergism with Phorbol Ester and Calcium-Mediated Activation of the NF-AT cis-Regulatory Motif

1994 • 39 citations