The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Studies of the binding of actinomycin and related compounds to DNA

1968 • 842 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro

1995 • 505 citations

Drug-target interactions: only the first step in the commitment to a programmed cell death?

1991 • 412 citations

Comparative evaluation of several DNA binding dyes in the detection of apoptosis‐associated chromatin degradation by flow cytometry

1992 • 375 citations

A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry

1994 • 319 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Oncogenes and cell death

1994 • 266 citations

Flow cytometric detection of apoptosis: Comparison of the assays of in situ DNA degradation and chromatin changes

1994 • 235 citations

Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry

1994 • 226 citations

Apoptosis in interleukin-3-dependent haemopoietic cells

1992 • 207 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

Serum deprivation induces apoptotic cell death in a subset of Balb/c 3T3 fibroblasts

1994 • 133 citations

Optimal detection of apoptosis by flow cytometry depends on cell morphology

1993 • 127 citations

Apoptosis: physiologic cell death.

1994 • 61 citations

A simple fluorescence method for surface antigen phenotyping of lymphocytes undergoing DNA fragmentation

1992 • 60 citations

Identification of Apoptotic and Necrotic Human Leukemic Cells by Flow Cytometry

1994 • 50 citations

A single-step staining procedure for the detection and sorting of unfixed apoptotic thymocytes.

1993 • 33 citations

Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: Detection of DNA strand breaks by flow cytometry using the in situ nick translation assay

1993 • 31 citations

A new method for quantitative estimation of the degree of DNA fragmentation utilizing agarose gel electrophoresis.

1994 • 9 citations