Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

1991 • 366 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

1992 • 221 citations

The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomas

1983 • 218 citations

Functional consequences of engagement of the T cell receptor by low affinity ligands.

1993 • 171 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

The Fab fragment of a directly activating monoclonal antibody that precipitates a disulfide-linked heterodimer from a helper T cell clone blocks activation by either allogeneic Ia or antigen and self-Ia.

1984 • 136 citations

Molecular associations on the T cell surface correlate with immunological memory

1990 • 130 citations

Physical association of CD4 with the T cell receptor.

1992 • 116 citations

Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies.

1989 • 103 citations

An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

1992 • 100 citations

The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.

1988 • 86 citations

Cross-linking and Conformational Change in T-cell Receptors: Role in Activation and in Repertoire Selection

1989 • 79 citations

The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.

1986 • 78 citations

Accessory cell function in the Con A response: role of Ia-positive and Ia-negative accessory cells.

1985 • 72 citations

A unified model for T cell antigen recognition and thymic selection of the T cell repertoire

1991 • 36 citations

Extensive CD4 cross-linking inhibits T cell activation by anti-receptor antibody but not by antigen

1992 • 27 citations

Asymmetry in the recognition of antigen: self class II MHC and non-self class II MHC molecules by the same T-cell receptor.

1989 • 25 citations

The use of the polymerase chain reaction to map CD4⁺ T cell epitopes

1991 • 23 citations

High fives or hand clasps?

1992 • 22 citations

Selective induction of growth factor production and growth factor receptor expression by different signals to a single t cell

1989 • 22 citations

High levels of IL-2 alter signal transduction in cloned IL-4-producing CD4 T cells.

1992 • 5 citations

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