Antibiotic inhibition of RNA catalysis: neomycin B binds to the catalytic core of the td group I intron displacing essential metal ions 1 1Edited by M. Yaniv
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References (78)
Rapid and efficient site-specific mutagenesis without phenotypic selection.
1985 • 7,573 citations
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection
1987 • 5,413 citations
A graphics model building and refinement system for macromolecules
1978 • 1,858 citations
Mapping adenines, guanines, and pyrimidines in RNA
1977 • 1,391 citations
Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis
1990 • 1,239 citations
The Molecular Basis of Antibiotic Action
1981 • 1,237 citations
A general two-metal-ion mechanism for catalytic RNA.
1993 • 1,125 citations
Structure of the A Site of Escherichia coli 16 S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic
1996 • 782 citations
Nucleic Acids and Molecular Biology
1994 • 777 citations
The ribosome: Structure, function and evolution
1991 • 531 citations
The Ribosome : structure, function, and evolution
1990 • 508 citations
RIBOSOMAL RNA AND TRANSLATION
1991 • 489 citations
Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme
1996 • 407 citations
Small molecules that selectively block RNA binding of HIV-1 rev protein inhibit rev function and viral production
1993 • 393 citations
Misreading of RNA codewords induced by aminoglycoside antibiotics.
1965 • 387 citations
Metal ion catalysis in the Tetrahymena ribozyme reaction
1993 • 386 citations
Defining the Inside and Outside of a Catalytic RNA Molecule
1989 • 368 citations
The guanosine binding site of the Tetrahymena ribozyme
1989 • 356 citations
Representation of the secondary and tertiary structure of group I introns
1994 • 293 citations
New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme
1996 • 291 citations
Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit
1994 • 286 citations
Iron(II) EDTA Used to Measure the Helical Twist Along Any DNA Molecule
1985 • 274 citations
Antibiotic inhibition of group I ribozyme function
1991 • 259 citations
RNA Sequence Determinants for Aminoglycoside Binding to an A-site rRNA Model Oligonucleotide
1996 • 252 citations
What factors determine cation coordination numbers?
1988 • 238 citations
Specific binding of aminoglycoside antibiotics to RNA
1995 • 213 citations
Direct Observation of Aminoglycoside−RNA Interactions by Surface Plasmon Resonance
1997 • 206 citations
A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavage
1997 • 195 citations
An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis
1997 • 192 citations
RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme
1992 • 182 citations
A novel RNA motif for neomycin recognition
1995 • 182 citations
Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA 1 1Edited by J. Karn
1998 • 176 citations
Rapid Combinatorial Synthesis of Aminoglycoside Antibiotic Mimetics: Use of a Polyethylene Glycol-Linked Amine and a Neamine-Derived Aldehyde in Multiple Component Condensation as a Strategy for the Discovery of New Inhibitors of the HIV RNA Rev Responsive Element
1996 • 173 citations
A second catalytic metal ion in a group I ribozyme
1997 • 171 citations
Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions.
1989 • 163 citations
Mapping of Catalytic Residues in the RNA Polymerase Active Center
1996 • 162 citations
Specificity of Aminoglycoside Binding to RNA Constructs Derived from the 16S rRNA Decoding Region and the HIV-RRE Activator Region
1997 • 160 citations
Metal Ions Play a Passive Role in the Hairpin Ribozyme Catalysed Reaction
1997 • 157 citations
LA AUTONOMÍA UNIVERSITARIA VISTA DESDE LAS CIENCIAS ADMINISTRATIVAS
1969 • 154 citations
Specific Binding of Aminoglycosides to a Human rRNA Construct Based on a DNA Polymorphism Which Causes Aminoglycoside-Induced Deafness
1997 • 142 citations
Inhibition of the Self-cleavage Reaction of the Human Hepatitis Delta Virus Ribozyme by Antibiotics
1996 • 140 citations
Non-competitive inhibition of group I intron RNA self-splicing by aminoglycoside antibiotics
1992 • 121 citations
In vitro selection of RNA lectins: using combinatorial chemistry to interpret ribozyme evolution
1995 • 119 citations
Dissociation Rate of Cognate Peptidyl‐tRNA from the A‐Site of Hyper‐Accurate and Error‐Prone Ribosomes
1994 • 116 citations
Nitrogen-15 nuclear magnetic resonance spectroscopy of neomycin B and related aminoglycosides
1983 • 115 citations
Complementary sets of noncanonical base pairs mediate RNA helix packing in the group I intron active site
1998 • 115 citations
Footprinting the Sites of Interaction of Antibiotics with Catalytic Group I Intron RNA
1993 • 104 citations
Interaction of Escherichia coli tRNA(Ser) with its cognate aminoacyl-tRNA synthetase as determined by footprinting with phosphorothioate-containing tRNA transcripts.
1991 • 103 citations
Monitoring of the Cooperative Unfolding of the sunY Group I Intron of Bacteriophage T4
1993 • 101 citations
Neomycin Inhibition of the Hammerhead Ribozyme Involves Ionic Interactions
1995 • 101 citations
Group I Intron Self-Splicing with Adenosine: Evidence for a Single Nucleoside-Binding Site
1991 • 100 citations
Electrostatic Interactions in RNA Aminoglycosides Binding
1997 • 98 citations
Binding and cleavage of nucleic acids by the "hairpin" ribozyme
1991 • 95 citations
Chemically modified RNA: approaches and applications.
1993 • 91 citations
Selective perturbation of G530 of 16 S rRNA by translational miscoding agents and a streptomycin-dependence mutation in protein S12
1994 • 87 citations
Tertiary Structure Around the Guanosine-Binding Site of the Tetrahymena Ribozyme
1992 • 79 citations
In Vitro Selection Analysis of Neomycin Binding RNAs with a Mutagenized Pool of Variants of the 16S rRNA Decoding Region
1996 • 71 citations
DRAWNA: A program for drawing schematic views of nucleic acids
1994 • 69 citations
3′-end labeling of RNA with recombinant yeast poly(A) polymerase
1993 • 68 citations
The environment of two metal ions surrounding the splice site of a group I intron.
1996 • 67 citations
Metal ion interaction with cosubstrate in self-splicing of group I introns
1997 • 66 citations
Purification and properties of T4 phage thymidylate synthetase produced by the cloned gene in an amplification vector.
1983 • 61 citations
Proximity Mapping of the Tet Repressor-Tetracycline-Fe2+ Complex by Hydrogen Peroxide Mediated Protein Cleavage
1995 • 60 citations
Deletion-tolerance and trans-splicing of the bacteriophage T4 td intron
1990 • 57 citations
Dissociation rates of peptidyl-tRNA from the P-site of E.coli ribosomes.
1996 • 57 citations
Genetic Delineation of Functional Components of the Group I Intron in the Phage T4 td Gene
1987 • 56 citations
Comparison of pH Dependencies of the Tetrahymena Ribozyme Reactions with RNA 2'-Substituted and Phosphorothioate Substrates Reveals a Rate-Limiting Conformational Step
1994 • 55 citations
Effects of Divalent Metal Ions on Individual Steps of the Tetrahymena Ribozyme Reaction
1997 • 50 citations
Lead cleavage sites in the core structure of group I intron-RNA
1993 • 47 citations
Visualizing metal-ion-binding sites in group I introns by iron(II)-mediated Fenton reactions
1998 • 46 citations
The Aminoglycoside Antibiotics
1981 • 46 citations
Compensatory mutations demonstrate that P8 and P6 are RNA secondary structure elements important for processing of a group I intron
1989 • 45 citations
Translocation of an RNA duplex on a ribozyme
1994 • 41 citations
Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.
1991 • 40 citations
Mapping metal ions at the catalytic centres of two intron-encoded endonucleases
1997 • 37 citations
Mechanism of Action of Aminoglycoside Antibiotics
1982 • 29 citations
Effects of mutations of the bulged nucleotide in the conserved P7 pairing element of the phage T4 td intron on ribozyme function
1991 • 26 citations
Interaction of Aminoglycoside Antibiotics with RNA
1996 • 16 citations