Effects of mutations of the bulged nucleotide in the conserved P7 pairing element of the phage T4 td intron on ribozyme function

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

1990 • 1,239 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

The Chemistry of Self-Splicing RNA and RNA Enzymes

1987 • 523 citations

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA

1987 • 508 citations

Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure

1982 • 501 citations

Making ends meet: a model for RNA splicing in fungal mitochondria

1982 • 459 citations

Conserved sequences and structures of group I introns: building an active site for RNA catalysis — a review

1988 • 451 citations

A self-splicing RNA excises an intron lariat

1986 • 449 citations

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

1990 • 412 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

Structural conventions for group I introns

1987 • 280 citations

Specific protein-nucleic acid recognition in ribonuclease T1–2′-guanylic acid complex: an X-ray study

1982 • 272 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

A Specific Amino Acid Binding Site Composed of RNA

1988 • 203 citations

New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing

1986 • 189 citations

A Labile Phosphodiester Bond at the Ligation Junction in a Circular Intervening Sequence RNA

1984 • 171 citations

Stereochemistry of RNA Cleavage by the Tetrahymena Ribozyme and Evidence that the Chemical Step Is Not Rate-Limiting

1989 • 155 citations

Role of a bulged A residue in a specific RNA-protein interaction

1987 • 134 citations

Intermolecular exon ligation of the rRNA precursor of tetrahymena: Oligonucleotides can function as 5′ exons

1985 • 114 citations

Ribozyme inhibitors. Deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor

1986 • 101 citations

Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena.

1987 • 99 citations

The self-splicing RNA of Tetrahymena is trapped in a less active conformation by gel purification

1990 • 76 citations

A 3′ splice site-binding sequence in the catalytic core of a group I intron

1990 • 75 citations

Mutational analysis of conserved nucleotides in a self-splicing group I intron

1990 • 69 citations

Mechanism of 3' splice site selection by the catalytic core of the sunY intron of bacteriophage T4: the role of a novel base-pairing interaction in group I introns.

1990 • 63 citations

Purification and properties of T4 phage thymidylate synthetase produced by the cloned gene in an amplification vector.

1983 • 61 citations

Deletion-tolerance and trans-splicing of the bacteriophage T4 td intron

1990 • 57 citations

Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis

1985 • 56 citations

Genetic Delineation of Functional Components of the Group I Intron in the Phage T4 td Gene

1987 • 56 citations

Compensatory mutations demonstrate that P8 and P6 are RNA secondary structure elements important for processing of a group I intron

1989 • 45 citations

Activation of a cryptic 5' splice site in the upstream exon of the phage T4 td transcript: exon context, missplicing, and mRNA deletion in a fidelity mutant.

1987 • 44 citations

Two domains for splicing in the intron of the phage T4 thymidylate synthase (td) gene established by nondirected mutagenesis

1987 • 44 citations

Effects of single-base bulges on intercalator binding to small RNA and DNA hairpins and a ribosomal RNA fragment

1989 • 43 citations

Stereoselective arginine binding is a phylogenetically conserved property of group I self-splicing RNAs.

1989 • 35 citations

Does unpaired adenosine-66 from helix II of Escherichia coli 5S RNA bind to protein L18?

1985 • 33 citations

Sequence specificity of the P6 pairing for splicing of the group Itdintron of phage T4

1989 • 20 citations

Two guanosine binding sites exist in group I self-splicing IVS RNAs.

1988 • 17 citations