Mechanism of Action of Aminoglycoside Antibiotics

Microtubule Assembly in the Absence of Added Nucleotides

1973 • 2,055 citations

Determinant of cistron specificity in bacterial ribosomes

1975 • 1,363 citations

Properties of the Penicillin‐Binding Proteins of Escherichia coli K12

1977 • 645 citations

Polypeptide Chain Initiation: Nucleotide Sequences of the Three Ribosomal Binding Sites in Bacteriophage R17 RNA

1969 • 640 citations

STREPTOMYCIN, SUPPRESSION, AND THE CODE

1964 • 481 citations

Molecular Mechanisms of Protein Biosynthesis

1977 • 472 citations

Identification and Functional Characterization of the Protein controlled by the Streptomycin-resistant Locus in E. coli

1969 • 461 citations

Misreading of RNA codewords induced by aminoglycoside antibiotics.

1965 • 387 citations

Inhibitors of protein biosynthesis

2006 • 335 citations

Ribosome structure determined by electron microscopy of Escherichia coli small subunits, large subunits and monomeric ribosomes

1976 • 296 citations

Effects of Membrane-Energy Mutations and Cations on Streptomycin and Gentamicin Accumulation by Bacteria: a Model for Entry of Streptomycin and Gentamicin in Susceptible and Resistant Bacteria

1977 • 276 citations

Mechanism of Kasugamycin Resistance in Escherichia coli

1972 • 268 citations

Misreading of Ribonucleic Acid Code Words Induced by Aminoglycoside Antibiotics

1968 • 267 citations

PHENOTYPIC REPAIR BY STREPTOMYCIN OF DEFECTIVE GENOTYPES IN E. COLI

1964 • 236 citations

Phenotypic suppression and misreading in Saccharomyces cerevisiae

1979 • 235 citations

Inhibitors of Protein Biosynthesis

1979 • 233 citations

Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics

1979 • 231 citations

Mechanism of Streptomycin Action on Bacteria: A Unitary Hypothesis

1961 • 227 citations

Change in Methylation of 16S Ribosomal RNA Associated with Mutation to Kasugamycin Resistance in Escherichia coli

1971 • 226 citations

Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics

1968 • 216 citations

Ribosomal proteins

1972 • 211 citations

STREPTOMYCIN ACTION AND THE RIBOSOME

1964 • 186 citations

Effect of Streptomycin on Escherichia Coli: Damage by Streptomycin to the Cell Membrane of Escherichia coli

1960 • 176 citations

Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes

1978 • 167 citations

Streptomycin Accumulation in Susceptible and Resistant Strains of Escherichia coli and Pseudomonas aeruginosa

1976 • 157 citations

A further study of misreading of codons induced by streptomycin and neomycin using ribopolynucleotides containing two nucleotides in alternating sequence as templates

1966 • 145 citations

Ribosomal Protein Conferring Sensitivity to the Antibiotic Spectinomycin in Escherichia coli

1969 • 138 citations

Altered Ribosomal Protein in Streptomycin-Dependent Escherichia coli

1969 • 135 citations

Mechanism of action of streptomycin in E. coli: interruption of the ribosome cycle at the initiation of protein synthesis.

1968 • 129 citations

The Inhibition of Ribosomal Translocation by Viomycin

1977 • 121 citations

EFFECT OF NEOMYCIN ON PHOSPHOINOSITIDE LABELLING AND CALCIUM BINDING IN GUINEA‐PIG INNER EAR TISSUES IN VIVO AND IN VITRO¹

1976 • 119 citations

Polypeptide synthesis with ribosomes from streptomycin-resistant and dependent E.coli

1962 • 119 citations

The Role of Guanosine Triphosphate in Translocation Reaction Catalyzed by Elongation Factor G

1974 • 119 citations

The sequence of some effects of streptomycin in Escherichia coli

1963 • 117 citations

Interaction of siomycin with the acceptor site of Escherichia coli ribosomes

1972 • 117 citations

Dual Interference of Hygromycin B with Ribosomal Translocation and with Aminoacyl-tRNA Recognition

1978 • 115 citations

Inhibition by kasugamycin of initiation complex formation on 30S ribosomes

1971 • 114 citations

Inhibition of ribosomal translocation by aminoglycoside antibiotics

1978 • 111 citations

Aminoglycoside antibiotics and eukaryotic protein synthesis: structure-function relationships in the stimulation of misreading with a wheat embryo system

1978 • 109 citations

Reversion of a streptomycin-dependent strain ofEscherichia coli

1970 • 107 citations

RIBOSOMAL LOCALIZATION OF STREPTOMYCIN SENSITIVITY

1962 • 107 citations

Negamycin, a novel hydrazide antibiotic

1971 • 107 citations

Electrophoretic and immunological studies on ribosomal proteins of 100 Escherichia coli revertants from streptomycin dependence

1973 • 107 citations

Binding of Dihydrostreptomycin to Escherichia coli Ribosomes: Characteristics and Equilibrium of the Reaction

1972 • 103 citations

Effect of Streptomycin on Escherichia Coli: Uptake of Streptomycin by Escherichia coli

1960 • 102 citations

Aminoglycoside antibiotics and eukaryotic protein synthesis: stimulation of errors in the translation of natural messengers in extracts of cultured human cells

1978 • 94 citations

N-ethyl maleimide as a probe for the study of functional sites and conformations of 30 S ribosomal subunits

1973 • 91 citations

Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation

1978 • 90 citations

Protein involved in the binding of dihydrostreptomycin to ribosomes of Escherichia coli

1973 • 90 citations

Alteration of ribosomal protein L6 in gentamicin-resistant strains of Escherichia coli. Effects on fidelity of protein synthesis

1979 • 87 citations

Binding of dihydrostreptomycin to ribosomal subunits

1968 • 83 citations

Peptide Chain Termination, Codon, Protein Factor, and Ribosomal Requirements

1969 • 81 citations

Binding of Specific Soluble Ribonucleic Acid to Ribosomes

1966 • 80 citations

Total syntheses of negamycin and the antipode

1972 • 79 citations

RNA CODEWORDS AND PROTEIN SYNTHESIS, V. EFFECT OF STREPTOMYCIN ON THE FORMATION OF RIBOSOME-sRNA COMPLEXES

1965 • 78 citations

Gentamicin resistance in clinical-isolates of Pseudomonas aeruginosa associated with diminished gentamicin accumulation and no detectable enzymatic modification.

1976 • 77 citations

Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli

1967 • 74 citations

Polyribosome metabolism in Escherichia coli treated with chloramphenicol, neomycin, spectinomycin or tetracycline

1969 • 72 citations

Resistance to viomycin conferred by RNA of either ribosomal subunit

1978 • 71 citations

Kasugamycin Resistance: 30 S Ribosomal Mutation with an Unusual Location on the Escherichia coli Chromosome

1970 • 68 citations

Alteration of ribosomal protein S17 by mutation linked to neamine resistance in Escherichia coli

1975 • 65 citations

Alteration of ribosomal protein L6 in mutants of Escherichia coli resistant to gentamicin

1977 • 63 citations

The effect of streptomycin on potassium flux in Escherichia coli

1961 • 61 citations

Ribosomal proteins

1972 • 60 citations

Rapid inhibition of polypeptide chain extension by streptomycin.

1968 • 60 citations

Dual actions of viomycin on the ribosomal functions

1976 • 59 citations

Mechanisms and Spectrum of Streptomycin Resistance in a Natural Population of Pseudomonas aeruginosa

1972 • 58 citations

Mechanism of inhibition of translocation by kanamycin and viomycin: A comparative study with fusidic acid

1980 • 58 citations

Streptomycin induced release of fMet-tRNA from the ribosomal initiation complex

1971 • 58 citations

A common site of action for polyamines and streptomycin

1962 • 57 citations

Function of Individual 30S Subunit Proteins of Escherichia coli . Effect of Specific Immunoglobulin Fragments (Fab) on Activities of Ribosomal Decoding Sites

1974 • 56 citations

Polyribosome depletion and blockage of the ribosome cycle by streptomycin in Escherichia coli

1969 • 56 citations

The Attachment Site of Streptomycin to the 30S Ribosomal Subunit

1972 • 56 citations

Concepts of membranes in regulation and excitation

1975 • 56 citations

Breakdown by Streptomycin of Initiation Complexes Formed on Ribosomes of Escherichia coli

1970 • 54 citations

Mechanism of Kasugamycin Action on Polypeptide Synthesis

1966 • 54 citations

Effects of Divalent Cations on Binding of Aminoglycoside Antibiotics to Human Serum Proteins and to Bacteria

1975 • 54 citations

Topography of the Escherichia coli 30S Ribosomal Subunit and Streptomycin Binding

1970 • 53 citations

Effects of Apramycin, a Novel Aminoglycoside Antibiotic on Bacterial Protein Synthesis

1979 • 52 citations

Specific binding of sRNA to ribosomes: effect of streptomycin.

1965 • 49 citations

Streptomycinoid Antibiotics: Synergism by Puromycin

1964 • 49 citations

Suppression activated by streptomycin and related antibiotics in drug sensitive strains

1965 • 49 citations

THE INHIBITION BY STREPTOMYCIN OF ADAPTIVE ENZYME FORMATION IN MYCOBACTERIA

1948 • 49 citations

Uptake of 14C-streptomycin by some Micro-organisms and its Relation to their Streptomycin Sensitivity

1962 • 47 citations

Radioactive Labeling of Phospholipids and Proteins by Cochlear Perfusion in the Guinea Pig and the Effect of Neomycin

1977 • 47 citations

Specificity in the Binding of Escherichia coli Ribosomes to Natural Messenger RNA

1970 • 46 citations

NEGAMYGIN, A MISCODING ANTIBIOTIC WITH A UNIQUE STRUCTURE

1972 • 46 citations

Effect of streptomycin and neomycin on physical properties of the ribosome

1967 • 46 citations

Fidelity in the Translation of Messenger Ribonucleic Acids in Mammalian Subcellular Systems^*

1966 • 46 citations

The Effects of Streptomycin or Dihydrostreptomycin Binding to 16S RNA or to 30S Ribosomal Subunits

1974 • 45 citations

Analysis of Ribosomes from Viomycin-Sensitive and -Resistant Strains of Mycobacterium smegmatis

1972 • 45 citations

ACCUMULATION OF LABEL FROM C ¹⁴ -STREPTOMYCIN BY ESCHERICHIA COLI

1962 • 45 citations

Paromomycin and Dihydrostreptomycin Binding to Escherichia coli Ribosomes

1976 • 45 citations

Streptomycin causes misreading of natural messenger by interacting with ribosomes after initiation.

1978 • 44 citations

The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis

1966 • 43 citations

Streptomycin Action and Anaerobiosis

1965 • 42 citations

Influence of Salts on the Uptake of Streptomycin by Escherichia coli

1961 • 42 citations

Ribosomal proteins. XXXVII. Determination of allelle types and amino acid exchanges in protein S12 of three streptomycin-resistant mutants of Escherichia coli

1972 • 41 citations

Structural basis of kanamycin for miscoding activity

1967 • 40 citations

Dihydrostreptomycin accumulation in E. coli

1974 • 40 citations

Progressive decrease in protein synthesis accuracy induced by streptomycin in Escherichia coli

1975 • 40 citations

Cyclic blockade of initiation sites by streptomycin-damaged ribosomes in Escherichia coli: an explanation for dominance of sensitivity

1973 • 39 citations

Triphasic concentration effects of gentamicin on activity and misreading in protein synthesis

1979 • 38 citations

Cell Wall Alterations of Gram-Negative Bacteria by Aminoglycoside Antibiotics

1974 • 38 citations

Interaction of aminoglycoside antibiotics with phospholipid liposomes studied by microelectrophoresis.

1979 • 37 citations

Binding of Dihydrostreptomycin to Escherichia coli Ribosomes: Kinetics of the Reaction

1972 • 36 citations

Comparative Analysis of the Effect of Aminoglycosides on Bacterial Protein Synthesis in vitro

1979 • 35 citations

Mechanism of action of negamycin in Escherichia coli K12. II. Miscoding activity in polypeptide synthesis directed by snythetic polynucleotide.

1970 • 33 citations

Fidelity of protein synthesis with chicken embryo mitochondrial and cytoplasmic ribosomes

1974 • 33 citations

Selective Inhibition of Initiating Ribosomes by Spectinomycin

1974 • 33 citations

Fidelity in Protein Synthesis

1968 • 32 citations

Ribosomes from a streptomycin-dependent strain of Escherichia coli

1967 • 32 citations

Altered Ribosomes in Antibiotic-Resistant Mutants of Mycobacterium smegmatis

1976 • 31 citations

Sucrose-dependent spectinomycin-resistant mutants of Escherichia coli

1976 • 29 citations

Differential inhibition of coliphage MS2 protein synthesis by ribosome-directed antibiotics

1972 • 29 citations

An effect of streptomycin on the dissociation of Escherichia coli 70 S ribosomes

1964 • 29 citations

Affinity labeling ofE. coliribosomes with a streptomycin-analogue

1973 • 28 citations

Misreading, a fundamental aspect of the mechanism of action of several aminoglycosides

1973 • 28 citations

Uptake of 14G-Streptomycin by Bacillus megaterium

1962 • 26 citations

Functional interaction of neomycin B and related antibiotics with 30S and 50S ribosomal subunits

1979 • 25 citations

MECHANISM OF ACTION OF NEGAMYCIN IN ESCHERICHIA COLI K 12

1970 • 25 citations

Binding of [ 14 C]tuberactinomycin O, an antibiotic closely related to viomycin, to the bacterial ribosome

1978 • 24 citations

Specific inhibition of the termination process of protein synthesis by negamycin

1976 • 24 citations

Negamycin inhibits termination of protein synthesis directed by phage f2 RNA in vitro

1974 • 24 citations

Alteration of ribosomal protein S17 by mutation linked to neamine resistance in Escherichia coli

1976 • 24 citations

Pleiotropic effects of ribosomal protein S4 studied in Escherichia coli mutants

1974 • 24 citations

The binding of kasugamycin to the Escherichia coli ribosomes.

1975 • 23 citations

Inhibition of polypeptide synthesis by kasugamycin, an aminoglycosidic antibiotic.

1966 • 23 citations

EFFECTS OF PROTEIN SYNTHESIS INHIBITORS ON THE LETHAL ACTION OF KANAMYCIN AND STREPTOMYCIN.

1963 • 22 citations

LOCALIZATION OF SENSITIVITY TO KANAMYCIN AND STREPTOMYCIN IN 30S RIBOSOMAL PROTEINS OF ESCHERICHIA COLI

1969 • 22 citations

Inhibition of Dihydrostreptomycin Binding to Mycobacterium smegmatis by Monovalent and Divalent Cation Salts

1976 • 22 citations

Coordinated alterations in ribosomes and cytoplasmic membrane in sucrose-dependent, spectinomycin-resistant mutants of Escherichia coli

1976 • 22 citations

EFFECTS OF VIOMYGIN AND POLYMYXIN B ON PROTEIN SYNTHESIS IN VITRO

1968 • 21 citations

A Mutant of Escherichia coli with a Defect in Energy Metabolism

1972 • 21 citations

MISCODING ACTIVITY OF AMINO SUGARS

1968 • 20 citations

Differential effects of aminoglycosides on cistron-specific initiation of protein synthesis

1972 • 19 citations

Mechanisms of streptomycin(SM)-resistance of highly SM-resistant Pseudomonas aeruginosa strains.

1976 • 19 citations

Streptomycin Action: Greater Inhibition of Escherichia coli Ribosome Function with Exogenous than with Endogenous Messenger Ribonucleic Acid

1969 • 18 citations

Alteration of ribosomal protein S2 in kasugamycin-resistant mutant derived from AB312

1974 • 18 citations

Mechanism of action of kasugamycin.

1965 • 18 citations

Sensitivity and resistance to streptomycin in relation with factor‐mediated dissociation of ribosomes

1971 • 18 citations

Peptidyl-Transferase Activity of Escherichia coli Ribosomes Digested by Ribonuclease T1

1973 • 18 citations

Formation of an altered enzyme by Escherichia coli in the presence of neomycin

1965 • 18 citations

Interaction of cytoplasmic membrane and ribosomes in Escherichia coli: spectinomycin-induced disappearance of membrane protein I-19

1977 • 17 citations

Analysis of ribosomal proteins in streptomycin resistant and dependent mutants isolated from streptomycin independent Escherichia coli strains

1975 • 16 citations

LOCALIZATION OF KANAMYGIN SENSITIVITY IN THE 23S CORE OF 30S RIBOSOMES OF E. COLI

1968 • 16 citations

Mutational alterations of either large or small ribosomal subunit for the kanamycin resistance

1980 • 16 citations

Partial Inhibition of Polysomal Ribosomes of Escherichia coli by Streptomycin

1973 • 15 citations

The action of streptomycin in a mutant of Escherichia coli with increased sensitivity to the antibiotic

1970 • 15 citations

Identification of components of the streptomycin-binding center ofE. coli MRE 600 ribosomes by photo-affinity labelling

1976 • 15 citations

Effect of streptomycin on the response of Escherichia coli ribosomes to the dissociation factor

1973 • 15 citations

Effect of streptomycin on lipid composition with particular reference to cyclic depsipeptide biosynthesis in Serratia marcescens and other micro-organisms

1970 • 15 citations

Studies on dissociation factor of bacterial ribosomes: Effect of antibiotics

1971 • 15 citations

Kanamycin-resistance mechanism of Pseudomonas aeruginosa governed by an R-plasmid independently of inactivating enzymes.

1977 • 14 citations

Effects of dihydrostreptomycin treatment in vivo on the ribosome cycle in Escherichia coli

1970 • 14 citations

Altered Surface Properties of Escherichia coli Associated With a Specific Amino Acid Change in the S12 Ribosomal Protein of Streptomycin-Resistant Mutants

1977 • 14 citations

EFFECTS OF AMINOGLYCOSIDE ANTIBIOTICS ON INITIATION OF VIRAL RNA-DIRECTED PROTEIN SYNTHESIS

1972 • 14 citations

Binding of streptomycin by ribosomes of sensitive, resistant and dependent Bacillus megaterium

1967 • 13 citations

Ambiguity in a Polypeptide-Synthesizing Extract from Saccharomyces cerevisiae

1973 • 13 citations

Streptomycin-Induced Synthesis of Abnormal Protein in an Escherichia coli Mutant

1974 • 12 citations

INHIBITION BY KASUGAMYGIN OF PROTEIN SYNTHESIS IN PIRICULARIA ORYZAE

1968 • 11 citations

Structure-activity relationships among the aminoglycoside antibiotics: comparison of the neomycins and hybrimycins

1970 • 11 citations

Osmotic Sensitivity in Staphylococcus aureus Induced by Streptomycin

1972 • 11 citations

Interaction of viomycin and aminoglycoside antibiotics with tubulin and microtubules.

1978 • 11 citations

Viomycin resistance: Alterations of either ribosomal subunit affect the binding of the antibiotic to the pair subunit and the entire ribosome becomes resistant to the drug

1979 • 11 citations

Interaction of aminoglycosides and other antibiotics with actin.

1979 • 10 citations

Binding of tobramycin to Escherichia coli ribosomes: Characteristics and equilibrium of the reaction.

1979 • 10 citations

Streptomycin, Dihydrostreptomycin, and the Gentamicins

1975 • 10 citations

Streptomycin Resistance and Ribosomal Proteins: Amino Acid Substitutions in the str Protein of One Streptomycin-Resistant Mutant of Escherichia coli K12 after Mutagenesis with Ethyl Methanesulfonate

1974 • 9 citations

Miscoding in a cell-free system from spleen.

1968 • 8 citations

The level of Fmet-tRNA on ribosomes from streptomycin treated cells

1970 • 8 citations

Studies on the ribosomal binding sites of natural messenger RNA

1973 • 7 citations

Effect of a bifunctional imidoester on dissociation of 70S ribosomes in Escherichia coli

1973 • 6 citations

Inhibitory effect of negamycin on polysomal ribosomes of Escherichia coli

1976 • 5 citations