The environment of two metal ions surrounding the splice site of a group I intron.

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

1990 • 1,239 citations

A general two-metal-ion mechanism for catalytic RNA.

1993 • 1,125 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Three-dimensional structure of a hammerhead ribozyme

1994 • 944 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

1995 • 675 citations

Ribozymes: A Distinct Class of Metalloenzymes

1993 • 440 citations

Metal ion catalysis in the Tetrahymena ribozyme reaction

1993 • 386 citations

Structural analysis of spermine and magnesium ion binding to yeast phenylalanine transfer RNA.

1978 • 377 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Representation of the secondary and tertiary structure of group I introns

1994 • 293 citations

Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism

1993 • 270 citations

Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA

1985 • 260 citations

Further refinement of the structure of yeast tRNAPhe

1978 • 243 citations

Pb(II)-catalysed cleavage of the sugar–phosphate backbone of yeast tRNAPhe—implications for lead toxicity and self-splicing RNA

1983 • 225 citations

RNA - ligand interactions:(I) magnesium binding sites in yeast tRNA^Phe

1977 • 221 citations

New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing

1986 • 189 citations

Lead-catalyzed cleavage of yeast tRNAPhe mutants

1990 • 156 citations

Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme

1989 • 139 citations

Metal coordination sites that contribute to structure and catalysis in the group I intron from Tetrahymena

1993 • 126 citations

Restrained refinement of the monoclinic form of yeast phenylalanine transfer RNA. Temperature factors and dynamics, coordinated waters, and base-pair propeller twist angles

1986 • 120 citations

A Tyrosyl-tRNA Synthetase Protein Induces Tertiary Folding of the Group I Intron Catalytic Core

1996 • 110 citations

Monitoring of the Cooperative Unfolding of the sunY Group I Intron of Bacteriophage T4

1993 • 101 citations

Analysis of the role of phosphate oxygens in the group I intron from Tetrahymena

1992 • 93 citations

Lead Ion Binding and RNA Chain Hydrolysis in Phenylalanine tRNA

1983 • 77 citations

DRAWNA: A program for drawing schematic views of nucleic acids

1994 • 69 citations

Identification of phosphate groups important to self-splicing of theTetrahymenarRNA intron as determined by phosphorothioate substitution

1989 • 58 citations

Lead cleavage sites in the core structure of group I intron-RNA

1993 • 47 citations

Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.

1991 • 40 citations

Analysis of magnesium, europium and lead binding sites in methionine initiator and elongator tRNAs by specific metal‐ion‐induced cleavages

1989 • 38 citations

Effects of mutations of the bulged nucleotide in the conserved P7 pairing element of the phage T4 td intron on ribozyme function

1991 • 26 citations

Evidence That the Guanosine Substrate of the Tetrahymena Ribozyme Is Bound in the Anti Conformation and That N7 Contributes to Binding

1994 • 12 citations