Role for the Ubiquitin-Proteasome System in the Vacuolar Degradation of Ste6p, the a-Factor Transporter in Saccharomyces cerevisiae

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ABC Transporters: From Microorganisms to Man

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Degradation of CFTR by the ubiquitin-proteasome pathway

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The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

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Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

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VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

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The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

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The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

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Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

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1991 • 268 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

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The a-factor pheromone of Saccharomyces cerevisiae is essential for mating.

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The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.

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Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.

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Endocytosis and Vacuolar Degradation of the Plasma Membrane-Localized Pdr5 ATP-Binding Cassette Multidrug Transporter in Saccharomyces cerevisiae

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The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole

1996 • 124 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

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Catabolite Inactivation of Fructose-1,6-bisphosphatase of Saccharomyces cerevisiae

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Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.

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The a-Factor Pheromone of Saccharomyces cerevisiae is Essential for Mating

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Catabolite inactivation of the yeast maltose transporter occurs in the vacuole after internalization by endocytosis

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The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein

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Degradation of the yeast MATα2 transcriptional regulator is mediated by the proteasome

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Functional and Physical Interactions between Partial Molecules of STE6, a Yeast ATP-binding Cassette Protein

1996 • 30 citations

Comparative Topology Studies in Saccharomyces cerevisiae and in Escherichia coli

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Analysis of the localization of STE6/CFTR chimeras in a Saccharomyces cerevisiae model for the cystic fibrosis defect CFTRΔF508

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ATP binding cassette proteins in yeast

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