The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

The yeast ubiquitin genes: a family of natural gene fusions.

1987 • 500 citations

Purification of a RAS-Responsive Adenylyl Cyclase Complex from Saccharomyces cerevisiae by Use of an Epitope Addition Method

1988 • 328 citations

In vivo degradation of a transcriptional regulator: The yeast α2 repressor

1990 • 243 citations

The identification of a second cell cycle control on the HO promoter in yeast: Cell cycle regulation of SWI5 nuclear entry

1990 • 215 citations

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

1990 • 184 citations

c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock.

1988 • 154 citations

How are substrates recognized by the ubiquitin-mediated proteolytic system

1989 • 125 citations

Chemical synthesis and expression of a cassette adapted ubiquitin gene.

1987 • 105 citations

Ubiquitin-Phytochrome Conjugates

1989 • 103 citations

Mutations affecting the stability of the fushi tarazu protein of Drosophila.

1990 • 85 citations

c-myc and c-myb Protein Degradation: Effect of Metabolic Inhibitors and Heat Shock

1988 • 33 citations