Effects of Statins on 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition Beyond Low-Density Lipoprotein Cholesterol

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

1996 • 7,450 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

2002 • 6,780 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

2000 • 5,760 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes

2004 • 4,752 citations

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial

2003 • 3,816 citations

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA

1995 • 3,524 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

The acute phase response

1994 • 2,927 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Effects of Atorvastatin on Early Recurrent Ischemic Events in Acute Coronary Syndromes<SUBTITLE>The MIRACL Study: A Randomized Controlled Trial</SUBTITLE>

2001 • 2,473 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 • 2,343 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease

1971 • 2,055 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?

2014 • 1,880 citations

PLEIOTROPIC EFFECTS OF STATINS

2004 • 1,860 citations

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

1998 • 1,860 citations

Multiple Risk Factor Intervention Trial

1982 • 1,670 citations

Measurement of C-Reactive Protein for the Targeting of Statin Therapy in the Primary Prevention of Acute Coronary Events

2001 • 1,537 citations

Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

1999 • 1,488 citations

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

2000 • 1,427 citations

Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels

1998 • 1,398 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 1,373 citations

Statins as a newly recognized type of immunomodulator

2000 • 1,371 citations

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

2003 • 1,303 citations

Effect of Pravastatin on Outcomes after Cardiac Transplantation

1995 • 1,302 citations

Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

2001 • 1,290 citations

Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia

2001 • 1,239 citations

Platelet Activation in Unstable Coronary Disease

1986 • 1,161 citations

The Effect of Cholesterol-Lowering and Antioxidant Therapy on Endothelium-Dependent Coronary Vasomotion

1995 • 1,123 citations

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

2001 • 1,108 citations

Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease

1996 • 1,066 citations

Cellular and molecular mechanisms of endothelial cell dysfunction.

1997 • 1,064 citations

Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk conditions

2004 • 1,050 citations

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

2001 • 1,035 citations

Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease

2001 • 1,016 citations

Effect of Partial Ileal Bypass Surgery on Mortality and Morbidity from Coronary Heart Disease in Patients with Hypercholesterolemia

1990 • 999 citations

Pravastatin Treatment Increases Collagen Content and Decreases Lipid Content, Inflammation, Metalloproteinases, and Cell Death in Human Carotid Plaques

2001 • 995 citations

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

2001 • 994 citations

Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month

1997 • 968 citations

Statin Therapy Accelerates Reendothelialization

2002 • 924 citations

Transplanted cord blood–derived endothelial precursor cells augment postnatal neovascularization

2000 • 908 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Ten-Year Mortality from Cardiovascular Disease in Relation to Cholesterol Level among Men with and without Preexisting Cardiovascular Disease

1990 • 834 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Influence of Pravastatin and Plasma Lipids on Clinical Events in the West of Scotland Coronary Prevention Study (WOSCOPS)

1998 • 804 citations

New insights into the pharmacodynamic and pharmacokinetic properties of statins

1999 • 802 citations

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

2001 • 783 citations

Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.

1998 • 767 citations

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

1995 • 660 citations

Statins Have Biphasic Effects on Angiogenesis

2002 • 659 citations

HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells

2001 • 653 citations

The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering

1984 • 631 citations

HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells

2001 • 601 citations

An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and Tissue Factor In Vivo and In Vitro

2001 • 597 citations

The evolving role of statins in the management of atherosclerosis

2000 • 565 citations

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

2000 • 558 citations

Single LDL Apheresis Improves Endothelium-Dependent Vasodilatation in Hypercholesterolemic Humans

1997 • 550 citations

HMG-CoA Reductase Inhibitors Improve Endothelial Dysfunction in Normocholesterolemic Hypertension via Reduced Production of Reactive Oxygen Species

2001 • 468 citations

Rho-Kinase Mediates Hypoxia-Induced Downregulation of Endothelial Nitric Oxide Synthase

2002 • 465 citations

Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications.

1989 • 461 citations

Atherosclerotic plaque rupture and thrombosis. Evolving concepts.

1990 • 457 citations

Hyperlipidemia and Coronary Disease

1995 • 444 citations

Bone Marrow–Derived Progenitor Cells Modulate Vascular Reendothelialization and Neointimal Formation

2002 • 434 citations

Rapid Reduction in C-Reactive Protein With Cerivastatin Among 785 Patients With Primary Hypercholesterolemia

2001 • 416 citations

Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase

1999 • 396 citations

Inhibition of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Blocks Hypoxia-mediated Down-regulation of Endothelial Nitric Oxide Synthase

1997 • 393 citations

Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice

2000 • 393 citations

3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Attenuate Vascular Smooth Muscle Proliferation by Preventing Rho GTPase-induced Down-regulation of p27

1999 • 389 citations

Statins Alter Smooth Muscle Cell Accumulation and Collagen Content in Established Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

2001 • 377 citations

Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability

2000 • 377 citations

S‐nitroso‐glutathione inhibits platelet activation in vitro and in vivo

1992 • 330 citations

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Increase Fibrinolytic Activity in Rat Aortic Endothelial Cells

1998 • 313 citations

Double-Edged Role of Statins in Angiogenesis Signaling

2002 • 307 citations

Neuroprotection mediated by changes in the endothelial actin cytoskeleton

2000 • 283 citations

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Interfere With Angiogenesis by Inhibiting the Geranylgeranylation of RhoA

2002 • 275 citations

Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins

2001 • 266 citations

Inhibition of Thromboxane Biosynthesis and Platelet Function by Simvastatin in Type IIa Hypercholesterolemia

1995 • 264 citations

Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease

2001 • 254 citations

Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits

2001 • 251 citations

Nitric Oxide Protects Against Leukocyte-Endothelium Interactions in the Early Stages of Hypercholesterolemia

1995 • 243 citations

HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells

2000 • 232 citations

Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia

2001 • 179 citations

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

1989 • 172 citations

Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis.

1991 • 166 citations

Enhanced Myosin Light Chain Phosphorylations as a Central Mechanism for Coronary Artery Spasm in a Swine Model With Interleukin-1β

1997 • 153 citations

Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells

2003 • 137 citations

Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models

2002 • 129 citations

Reduction of Platelet Activity Markers in Type II Hypercholesterolemic Patients by a HMG-CoA-Reductase Inhibitor

1999 • 125 citations

Elucidation off the role of plaque instability and rupture in acute coronary events

1995 • 119 citations

HMG-CoA reductase inhibitor therapy and stroke risk reduction: an analysis of clinical trials data

1998 • 113 citations

Endothelial nitric oxide synthase is essential for the HMG‐CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia

2001 • 113 citations

HMG-CoA reductase inhibition improves endothelial cell function and inhibits smooth muscle cell proliferation in human saphenous veins

2000 • 103 citations

Platelet Cytosolic Ca ²⁺ and Membrane Dynamics in Patients With Primary Hypercholesterolemia

1995 • 81 citations

MEASUREMENT OF C-REACTIVE PROTEIN FOR THE TARGETING OF STATIN THERAPY IN THE PRIMARY PREVENTION OF ACUTE CORONARY EVENTS

2001 • 63 citations

The Pravastatin Inflammation CRP Evaluation (PRINCE): Rationale and design

2001 • 58 citations

Platelet Deposition on Eroded Vessel Walls at a Stenotic Shear Rate Is Inhibited by Lipid-Lowering Treatment With Atorvastatin

1999 • 55 citations

Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol

1995 • 54 citations

Control of signal transduction and morphogenesis by Ras

1995 • 48 citations

Influence of cholesterol-lowering on plasma membrane lipids and function.

1996 • 44 citations

Combination of Fosinopril and Pravastatin Decreases Platelet Response to Thrombin Receptor Agonist in Monkeys

1998 • 36 citations

Platelet α2-adrenergic receptors in hypercholesterolemia: Relationship between binding studies and epinephrine-induced platelet aggregation

1997 • 24 citations

Deleted Work

1955 • 0 citations