Elucidation off the role of plaque instability and rupture in acute coronary events

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes

1992 • 2,655 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

The pathogenesis of coronary artery disease and the acute coronary syndromes (First of two parts)

1992 • 1,958 citations

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

1994 • 1,913 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?

1988 • 1,483 citations

Angiographic progression of coronary artery disease and the development of myocardial infarction

1988 • 1,450 citations

Unstable angina. A classification.

1989 • 1,391 citations

A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

1994 • 1,300 citations

INFLUENCE OF PLAQUE CONFIGURATION AND STRESS DISTRIBUTION ON FISSURING OF CORONARY ATHEROSCLEROTIC PLAQUES

1989 • 1,249 citations

Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content.

1993 • 1,132 citations

Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture.

1994 • 1,125 citations

Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

1985 • 1,053 citations

Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi.

1983 • 1,023 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP).

1994 • 896 citations

Coronary Angioscopy in Patients with Unstable Angina Pectoris

1986 • 877 citations

Relation between Myocardial Blood Flow and the Severity of Coronary-Artery Stenosis

1994 • 869 citations

Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.

1994 • 862 citations

Coronary Vasospasm as a Possible Cause of Myocardial Infarction

1978 • 845 citations

Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease.

1993 • 833 citations

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

1990 • 767 citations

Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and patients with coronary artery disease.

1991 • 673 citations

Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels.

1992 • 667 citations

Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.

1994 • 602 citations

Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.

1994 • 576 citations

Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases.

1995 • 556 citations

Lipoproteins and Atherogenesis

1990 • 549 citations

Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCATOR) Study Group.

1992 • 548 citations

Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography.

1982 • 497 citations

Insights into the pathogenesis of acute ischemic syndromes.

1988 • 483 citations

Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.

1985 • 472 citations

Angiographic evolution of coronary artery morphology in unstable angina

1986 • 464 citations

Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications.

1989 • 461 citations

Atherosclerotic plaque rupture and thrombosis. Evolving concepts.

1990 • 457 citations

Diagnosing and managing unstable angina. Agency for Health Care Policy and Research.

1994 • 430 citations

Coronary Arteriographic Findings Soon after Non-Q-Wave Myocardial Infarction

1986 • 424 citations

Endothelium-derived relaxing factor and coronary vasospasm.

1989 • 423 citations

Factors influencing the presence or absence of acute coronary artery thrombi in sudden ischaemic death

1989 • 396 citations

George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry.

1988 • 389 citations

Intermittent Coronary Occlusion in Acute Myocardial Infarction

1987 • 373 citations

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.

1994 • 372 citations

Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium.

1994 • 338 citations

Mechanical properties of model atherosclerotic lesion lipid pools.

1994 • 258 citations

Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction: quantitative angiographic observations.

1986 • 251 citations

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

1990 • 244 citations

Morphology of the endothelium over atherosclerotic plaques in human coronary arteries.

1988 • 243 citations

Pathophysiology of reverse cholesterol transport. Insights from inherited disorders of lipoprotein metabolism.

1989 • 241 citations

The prevalence and clinical significance of residual myocardial ischemia 2 weeks after uncomplicated non-Q wave infarction: a prospective natural history study.

1986 • 234 citations

George Lyman Duff Memorial Lecture. Arterial imaging and atherosclerosis reversal.

1994 • 222 citations

Is vasospasm related to platelet deposition? Relationship in a porcine preparation of arterial injury in vivo.

1987 • 216 citations

Coronary artery vasoconstriction routinely occurs after percutaneous transluminal coronary angioplasty. A quantitative arteriographic analysis.

1988 • 212 citations

High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits.

1989 • 211 citations

Composition and classification of human atherosclerotic lesions

1992 • 200 citations

Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits.

1994 • 184 citations

The role of intracoronary thrombus in unstable angina: angiographic assessment and thrombolytic therapy during ongoing anginal attacks.

1988 • 175 citations

Toward the quiescent coronary plaque

1993 • 173 citations

Vasoreactivity of the culprit lesion in unstable angina.

1994 • 166 citations

Smooth muscle cell abundance and fibroblast growth factors in coronary lesions of patients with nonfatal unstable angina. A clue to the mechanism of transformation from the stable to the unstable clinical state.

1993 • 164 citations

Circulating and tissue endothelin immunoreactivity in hypercholesterolemic pigs.

1993 • 161 citations

Mechanisms of monocyte recruitment and accumulation

1993 • 147 citations

Morphological characteristics of clinically significant coronary artery stenosis in stable angina.

1986 • 127 citations

Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL.

1994 • 117 citations

The role of collateral circulation in the various coronary syndromes.

1979 • 100 citations

Endothelial cell storage and release of endothelin as a cardioregulatory mechanism.

1994 • 88 citations

Adenovirus-mediated transfer of a gene encoding human apolipoprotein A-I into normal mice increases circulating high-density lipoprotein cholesterol.

1994 • 86 citations

Quantitative angiographic morphology of the coronary artery lesions at risk of thrombotic occlusion.

1992 • 82 citations

Time of flight quantification of coronary flow with echo‐planar MRI

1993 • 77 citations

Abnormal vasomotor changes early after coronary angioplasty. A quantitative arteriographic study of their time course.

1991 • 57 citations

13C-NMR spectroscopy of human atherosclerotic lesions. Relation between fatty acid saturation, cholesteryl ester content, and luminal obstruction.

1994 • 56 citations

Reversal of coronary atherosclerosis. Clinical promise as the basis for noninvasive management of coronary artery disease.

1994 • 43 citations

Cellular mechanisms for the oxidative modification of lipoproteins

1994 • 40 citations

Regression or stabilization of atherosclerosis means regression or stabilization of what we don't see in the arteriogram

1995 • 34 citations

The effects of early coronary patency on the evolution of myocardial infarction: a prospective arteriographic study.

1987 • 21 citations

Refractory Prinzmetal Angina Treated with Cyproheptadine

1994 • 12 citations

Deleted Work

1955 • 0 citations