Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

1964 • 2,108 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene

1980 • 556 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells

1978 • 382 citations

Immunoglobulin Genes

1983 • 341 citations

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

1981 • 327 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12.

1979 • 238 citations

Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines

1982 • 228 citations

Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain

1980 • 228 citations

Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

1976 • 171 citations

Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.

1981 • 109 citations

Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

1982 • 107 citations

Regulated expression of an immunoglobulin kappa gene introduced into a mouse lymphoid cell line.

1982 • 100 citations

Functional V region formation during in vitro culture of a murine immature B precursor cell line

1983 • 52 citations