Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Bacteriophage P1 site-specific recombination

1981 • 762 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.

1990 • 253 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

1981 • 190 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells

1991 • 139 citations

Localization of murine Ig-1b and Ig-1a (IgG 2a) allotypic determinants detected with monoclonal antibodies

1979 • 134 citations

Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.

1983 • 101 citations

Location of crossovers during gene targeting with insertion and replacement vectors.

1993 • 91 citations

Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene.

1993 • 85 citations

Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

1984 • 79 citations

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1984 • 65 citations

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

1987 • 64 citations

Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.

1990 • 59 citations

A new model for investigations of T-cell functions in mice: differential immunosuppressive effects of two monoclonal anti-thy-1.2 antibodies

1982 • 58 citations

Preferential rearrangement of the immunoglobulin kappa chain joining region J kappa 1 and J kappa 2 segments in mouse spleen DNA.

1985 • 45 citations

B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment.

1987 • 38 citations

A novel germ-line J_Ktranscript starting immediately upstream of J_K1

1989 • 34 citations

Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.

1993 • 21 citations

Location of Crossovers during Gene Targeting with Insertion and Replacement Vectors

1993 • 18 citations

Rearrangement of the chicken lambda light chain locus: a silencer/antisilencer regulation

1994 • 13 citations