ERK-Dependent Bim Modulation Downstream of the 4-1BB-TRAF1 Signaling Axis Is a Critical Mediator of CD8 T Cell Survival In Vivo

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 • 597 citations

All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction

2002 • 594 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

Control of T Cell Viability

2004 • 367 citations

4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-1

2002 • 358 citations

Structural basis for self-association and receptor recognition of human TRAF2

1999 • 355 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

2005 • 303 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection

2002 • 270 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

Immune Responses in 4-1BB (CD137)-Deficient Mice

2002 • 221 citations

Recruitment of CD40 and Tumor Necrosis Factor Receptor-associated Factors 2 and 3 to Membrane Microdomains during CD40 Signaling

2000 • 201 citations

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2002 • 195 citations

Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.

1995 • 178 citations

TRAF1 Is a Negative Regulator of TNF Signaling

2001 • 170 citations

Human 4-1BB (CD137) Signals Are Mediated by TRAF2 and Activate Nuclear Factor-κB

1998 • 165 citations

The Role of Antigen in the Localization of Naive, Acutely Activated, and Memory CD8+ T Cells to the Lung During Influenza Pneumonia

2001 • 156 citations

4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination

2000 • 143 citations

Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling

2002 • 142 citations

IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival

2006 • 140 citations

A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo

2004 • 130 citations

The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases

2003 • 128 citations

Role of TNF Receptor-Associated Factor 2 and p38 Mitogen-Activated Protein Kinase Activation During 4-1BB-Dependent Immune Response

2000 • 127 citations

Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses

2004 • 109 citations

Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling

2006 • 109 citations

Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-κB Activation

2003 • 101 citations

TRAF1 is a TNF inducible regulator of NF‐κB activation

1999 • 86 citations

CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

2007 • 85 citations

A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival

2006 • 84 citations

TNF family ligands define niches for T cell memory

2007 • 80 citations

TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40

2002 • 65 citations

Role of the Stress Kinase Pathway in Signaling Via the T Cell Costimulatory Receptor 4-1BB

1999 • 65 citations

Caspase-mediated Cleavage Converts the Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-1 from a Selective Modulator of TNF Receptor Signaling to a General Inhibitor of NF-κB Activation

2003 • 41 citations

TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45

2005 • 35 citations