A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

A Role for CD40 Expression on CD8 ⁺ T Cells in the Generation of CD8 ⁺ T Cell Memory

2002 • 629 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

Dynamic programming of CD8+ T lymphocyte responses

2003 • 401 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-1

2002 • 358 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

What messenger RNA capping tells us about eukaryotic evolution

2002 • 351 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

Costimulation of CD28- T lymphocytes by 4-1BB ligand.

1997 • 333 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

Generation and maintenance of memory CD4+ T Cells

2009 • 303 citations

Compromised Influenza Virus-Specific CD8⁺-T-Cell Memory in CD4⁺-T-Cell-Deficient Mice

2002 • 286 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

Analysis of 4-1BB Ligand (4-1BBL)-Deficient Mice and of Mice Lacking Both 4-1BBL and CD28 Reveals a Role for 4-1BBL in Skin Allograft Rejection and in the Cytotoxic T Cell Response to Influenza Virus

1999 • 280 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection

2002 • 270 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death.

1997 • 256 citations

CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

2003 • 226 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections

2003 • 207 citations

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2002 • 195 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Generation and maintenance of memory T cells

2001 • 179 citations

Role of CD4 T Cell Help and Costimulation in CD8 T Cell Responses During Listeria monocytogenes Infection

2003 • 168 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

Tumor necrosis factor receptor family members in the immune system

1998 • 163 citations

In vivoproliferation of naïve and memory influenza-specific CD8⁺T cells

1999 • 146 citations

4-1BB Costimulation Is Required for Protective Anti-Viral Immunity After Peptide Vaccination

2000 • 143 citations

4-1BB-Specific Monoclonal Antibody Promotes the Generation of Tumor-Specific Immune Responses by Direct Activation of CD8 T Cells in a CD40-Dependent Manner

2002 • 138 citations

Role of TNF Receptor-Associated Factor 2 and p38 Mitogen-Activated Protein Kinase Activation During 4-1BB-Dependent Immune Response

2000 • 127 citations

4-1BB (CD137) controls the clonal expansion and survival of CD8 T cellsin vivo but does not contribute to the development of cytotoxicity

2002 • 117 citations

Regulation of CD8+ T Cells Undergoing Primary and Secondary Responses to Infection in the Same Host

2003 • 111 citations

An Enhanced System for Construction of Adenoviral Vectors by the Two-Plasmid Rescue Method

2000 • 101 citations

Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection

2000 • 96 citations

Role of ICOS versus CD28 in antiviral immunity

2002 • 89 citations

CD28 Mediates a Potent Costimulatory Signal for Rapid Degradation of IκBβ Which Is Associated with Accelerated Activation of Various NF-κB/Rel Heterodimers

1996 • 70 citations

Role of the Stress Kinase Pathway in Signaling Via the T Cell Costimulatory Receptor 4-1BB

1999 • 65 citations

Concurrent Naive and Memory CD8+ T Cell Responses to an Influenza A Virus

2001 • 60 citations

Creating CTL targets with epitope-linked beta 2-microglobulin constructs.

1998 • 60 citations

Creating CTL Targets with Epitope-Linked β2-Microglobulin Constructs

1998 • 47 citations

Quantitative analysis of the CD8⁺T–cell response to readily eliminated and persistent viruses

2000 • 41 citations