Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-κB Activation

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review

2001 • 730 citations

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

1996 • 484 citations

Caspase Activation Is Required for T Cell Proliferation

1999 • 462 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

Early Activation of Caspases during T Lymphocyte Stimulation Results in Selective Substrate Cleavage in Nonapoptotic Cells

1999 • 387 citations

Structural basis for self-association and receptor recognition of human TRAF2

1999 • 355 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

The TNF-receptor-associated factor family

2001 • 344 citations

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

1996 • 339 citations

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

2000 • 336 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

1999 • 289 citations

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

2002 • 274 citations

CD40−Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions: Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization

1998 • 248 citations

Targeted Disruption of TRAF3 Leads to Postnatal Lethality and Defective T-Dependent Immune Responses

1996 • 239 citations

Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells

1997 • 207 citations

Recruitment of CD40 and Tumor Necrosis Factor Receptor-associated Factors 2 and 3 to Membrane Microdomains during CD40 Signaling

2000 • 201 citations

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

1999 • 200 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

CD40 signaling in human dendritic cells is initiated within membrane rafts

2000 • 183 citations

Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling

2001 • 182 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

TRAF1 Is a Negative Regulator of TNF Signaling

2001 • 170 citations

The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-κB and c-Jun N-terminal Kinase

1999 • 169 citations

Keratin attenuates tumor necrosis factor–induced cytotoxicity through association with TRADD

2001 • 169 citations

High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization

1999 • 154 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells

2002 • 147 citations

Molecular basis for CD40 signaling mediated by TRAF3

2000 • 143 citations

Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling

2002 • 142 citations

TRAF2 Deficiency Results in Hyperactivity of Certain TNFR1 Signals and Impairment of CD40-Mediated Responses

1999 • 133 citations

The Binding Site for TRAF2 and TRAF3 but Not for TRAF6 Is Essential for CD40-Mediated Immunoglobulin Class Switching

2002 • 120 citations

Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6) Stimulates Extracellular Signal–regulated Kinase (ERK) Activity in CD40 Signaling Along a Ras-independent Pathway

1998 • 120 citations

Selective Inhibition of FLICE-like Inhibitory Protein (FLIP) Expression With Small Interfering RNA Oligonucleotides (siRNAs) Is Sufficient to Sensitize Tumor Cells for TRAIL-Induced Apoptosis

2002 • 114 citations

Binding Sites of Cytoplasmic Effectors TRAF1, 2, and 3 on CD30 and Other Members of the TNF Receptor Superfamily

1997 • 101 citations

Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation

1999 • 98 citations

Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40

1999 • 98 citations

TRAF1 is a TNF inducible regulator of NF‐κB activation

1999 • 86 citations

Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms

2002 • 81 citations

TNF Receptor-Associated Factor-3 Signaling Mediates Activation of p38 and Jun N-Terminal Kinase, Cytokine Secretion, and Ig Production Following Ligation of CD40 on Human B Cells

1998 • 80 citations

Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement.

1997 • 72 citations

TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis

2001 • 69 citations

Caspase‐induced inactivation of the anti‐apoptotic TRAF1 during Fas ligand‐mediated apoptosis

2000 • 68 citations

Caspase-mediated Cleavage Converts the Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-1 from a Selective Modulator of TNF Receptor Signaling to a General Inhibitor of NF-κB Activation

2003 • 41 citations

Activation of the Janus Kinase 3-STAT5a Pathway After CD40 Triggering of Human Monocytes But Not of Resting B Cells

1999 • 39 citations

Role of JAK3 in CD40-Mediated Signaling

1998 • 34 citations

Inhibition of caspase or FADD function blocks proliferation but not MAP kinase‐activation and interleukin‐2‐production during primary stimulation of T cells

2002 • 28 citations

Inhibition of caspase or FADD function blocks proliferation but not MAP kinase-activation and interleukin-2-production during primary stimulation of T cells

2002 • 24 citations

Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33–34

1997 • 20 citations