Caspase-1 Contributes toChlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factorin vivo

2006 • 914 citations

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

2006 • 857 citations

Inhibition of Apoptosis in Chlamydia-infected Cells: Blockade of Mitochondrial Cytochrome c Release and Caspase Activation

1998 • 586 citations

Identification of a Chlamydial Protease–Like Activity Factor Responsible for the Degradation of Host Transcription Factors

2001 • 378 citations

Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways.

1997 • 365 citations

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

2007 • 343 citations

Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection

1995 • 333 citations

Toll-Like Receptor-2, but Not Toll-Like Receptor-4, Is Essential for Development of Oviduct Pathology in Chlamydial Genital Tract Infection

2003 • 286 citations

Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice

1997 • 254 citations

A Predominant Role for Antibody in Acquired Immunity to Chlamydial Genital Tract Reinfection

2005 • 224 citations

Vaccination with theChlamydia trachomatisMajor Outer Membrane Protein Can Elicit an Immune Response as Protective as That Resulting from Inoculation with Live Bacteria

2005 • 172 citations

Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection

1995 • 168 citations

Histopathologic Changes Related to Fibrotic Oviduct Occlusion After Genital Tract Infection of Mice With Chlamydia muridarum

2004 • 157 citations

Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle

2006 • 155 citations

Apoptosis of Epithelial Cells and Macrophages Due to Infection with the Obligate Intracellular PathogenChlamydia psittaci

1998 • 146 citations

Pathogenesis of trachoma: the stimulus for inflammation.

1987 • 143 citations

The Interleukin‐1 Receptor Family

2006 • 128 citations

Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition.

1999 • 117 citations

Intranasal Vaccination with a Secreted Chlamydial Protein Enhances Resolution of GenitalChlamydia muridarumInfection, Protects against Oviduct Pathology, and Is Highly Dependent upon Endogenous Gamma Interferon Production

2006 • 110 citations

Chlamydia trachomatis Infection of Epithelial Cells Induces the Activation of Caspase-1 and Release of Mature IL-18

2000 • 107 citations

Pathogenesis of Chlamydia induced pelvic inflammatory disease

1999 • 107 citations

An Inclusion Membrane Protein from Chlamydia trachomatis Enters the MHC Class I Pathway and Stimulates a CD8+ T Cell Response

2003 • 104 citations

Chlamydial Infection in Inducible Nitric Oxide Synthase Knockout Mice

1998 • 103 citations

Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection

1996 • 103 citations

Gamma Interferon Production by Cytotoxic T Lymphocytes Is Required for Resolution ofChlamydia trachomatisInfection

1998 • 101 citations

Degradation of the Proapoptotic Proteins Bik, Puma, and Bim with Bcl-2 Domain 3 Homology in Chlamydia trachomatis -Infected Cells

2005 • 100 citations

Differential Sensitivity of Distinct Chlamydia trachomatis Isolates to IFN-γ-Mediated Inhibition

1999 • 92 citations

Interleukin-12 Production Is Required for Chlamydial Antigen-Pulsed Dendritic Cells To Induce Protection against Live Chlamydia trachomatis Infection

1999 • 91 citations

Priming withChlamydia trachomatisMajor Outer Membrane Protein (MOMP) DNA followed by MOMP ISCOM Boosting Enhances Protection and Is Associated with Increased Immunoglobulin A and Th1 Cellular Immune Responses

2000 • 88 citations

Human Antibody Responses to a Chlamydia-Secreted Protease Factor

2004 • 83 citations

Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection

1999 • 79 citations

Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chlamydia trachomatis.

1993 • 77 citations

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).

1996 • 77 citations

Sexually Transmitted Diseases and Tubal Pregnancy

1990 • 75 citations

NK T Cell Activation Promotes Chlamydia trachomatis Infection In Vivo

2005 • 73 citations

The Hypothetical Protein CT813 Is Localized in theChlamydia trachomatisInclusion Membrane and Is Immunogenic in Women Urogenitally Infected withC. trachomatis

2006 • 72 citations

Role for Inducible Nitric Oxide Synthase in Protection from ChronicChlamydia trachomatisUrogenital Disease in Mice and Its Regulation by Oxygen Free Radicals

2001 • 68 citations

A Role for Interleukin-6 in Host Defense against MurineChlamydia trachomatisInfection

1998 • 64 citations

Epidemic Lymphogranuloma Venereum During Epidemics of Crack Cocaine Use and HIV Infection in the Bahamas

2002 • 63 citations

Clearance ofChlamydia trachomatisfrom the Murine Genital Mucosa Does Not Require Perforin-Mediated Cytolysis or Fas-Mediated Apoptosis

1999 • 61 citations

IL-33: A Sheep in Wolf’s Clothing?

2007 • 59 citations

Production of a Proteolytically Active Protein, Chlamydial Protease/Proteasome-Like Activity Factor, by Five Different Chlamydia Species

2005 • 54 citations

Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice

2004 • 49 citations

Francisella Tularensis: Activation of the Inflammasome

2007 • 47 citations

Inducible Nitric Oxide Synthase Does Not Affect Resolution of Murine Chlamydial Genital Tract Infections or Eradication of Chlamydiae in Primary Murine Cell Culture

1998 • 47 citations

Inhibition of Matrix Metalloproteinases Protects Mice from Ascending Infection and Chronic Disease Manifestations Resulting from UrogenitalChlamydia muridarumInfection

2006 • 46 citations

Neither Interleukin-6 nor Inducible Nitric Oxide Synthase Is Required for Clearance ofChlamydia trachomatisfrom the Murine Genital Tract Epithelium

1998 • 45 citations

Chlamydia trachomatis Mouse Pneumonitis Lung Infection in IL-18 and IL-12 Knockout Mice: IL-12 Is Dominant over IL-18 for Protective Immunity

2000 • 44 citations

Immunity toChlamydia trachomatisMouse Pneumonitis Induced by Vaccination with Live Organisms Correlates with Early Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-12 Production and with Dendritic Cell-Like Maturation

1999 • 40 citations

Experimental Chlamydia trachomatis Salpingitis in Mice: Initial Studies on the Characterization of the Leukocyte Response to Chlamydial Infection

1989 • 40 citations

Inhibition of Proteolytic Activity of a Chlamydial Proteasome/Protease-Like Activity Factor by Antibodies from Humans Infected with Chlamydia trachomatis

2005 • 39 citations

Activation of mouse peritoneal macrophages in vitro or in vivo by recombinant murine gamma interferon inhibits the growth of Chlamydia trachomatis serovar L1

1988 • 36 citations

Correlation of infertility with altered tubal morphology and function in mice with salpingitis induced by a human genital-tract isolate of Chlamydia trachomatis

1990 • 35 citations

Immunoaccessible peptide sequences of the major outer membrane protein from Chlamydia trachomatis serovar C

1990 • 27 citations

Role of matrix metalloproteinase‐7 in the modulation of a Chlamydia trachomatis infection

2005 • 24 citations

An experimental model for salpingitis due to Chlamydia trachomatis and residual tubal infertility in the mouse

1990 • 10 citations