Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition.

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis

1981 • 1,054 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

1995 • 411 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways.

1997 • 365 citations

Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection

1995 • 333 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract

1995 • 263 citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.

1993 • 255 citations

Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice

1997 • 254 citations

Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.

1994 • 211 citations

Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease

1994 • 210 citations

Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response

1997 • 204 citations

Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice

1997 • 195 citations

Induction of Tryptophan DegradationIn VitroandIn Vivo: A γ-Interferon-Stimulated Activity

1986 • 181 citations

Early gamma interferon responses in lethal and nonlethal murine blood-stage malaria

1997 • 179 citations

Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection

1988 • 175 citations

Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection

1995 • 168 citations

Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis.

1994 • 167 citations

Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.

1993 • 166 citations

Distal Tubal Obstruction Induced by Repeated Chlamydia trachomatis Salpingeal Infections in Pig-Tailed Macaques

1987 • 153 citations

T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring

1996 • 149 citations

Interferon-Induced Indoleamine 2,3-Dioxygenase Activity InhibitsChlamydia psittaciReplication in Human Macrophages

1989 • 136 citations

Effect of gamma interferon on resolution of murine chlamydial genital infection

1992 • 122 citations

A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis

1990 • 113 citations

Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor

1988 • 108 citations

Gamma interferon-induced nitric oxide production reduces Chlamydia trachomatis infectivity in McCoy cells

1993 • 103 citations

Chlamydial Infection in Inducible Nitric Oxide Synthase Knockout Mice

1998 • 103 citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation

1993 • 101 citations

In vivo regulation of nitric oxide production by tumor necrosis factor alpha and gamma interferon, but not by interleukin-4, during blood stage malaria in mice

1996 • 99 citations

Role of CD8 T cells in primary Chlamydia infection

1995 • 97 citations

Monoclonal immunoglobulin A antibody to the major outer membrane protein of the Chalamydia trachomatis mouse pneumonitis biovar protects mice against a chlamydial genital challenge

1997 • 93 citations

Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis

1997 • 89 citations

Lymphokine enhances oxygen-independent activity against intracellular pathogens.

1983 • 81 citations

The Ribosomal Intergenic Spacer and Domain I of the 23S rRNA Gene Are Phylogenetic Markers for Chlamydia spp.

1997 • 79 citations

Lymphokine-mediated inhibition of Chlamydia replication in mouse fibroblasts is neutralized by anti-gamma interferon immunoglobulin

1983 • 79 citations

Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice

1988 • 69 citations

Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma

1996 • 65 citations

Effect of interferon on the growth of Chlamydia trachomatis in mouse fibroblasts (L cells)

1983 • 62 citations

Cellular Immunity to the Mouse Pneumonitis Agent

1984 • 61 citations

The molecular mechanism of T-cell control of Chlamydia in mice: role of nitric oxide.

1996 • 61 citations

B‐cell‐deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis

1997 • 60 citations

The anti-chlamydial and anti-proliferative activities of recombinant murine interferon-gamma are not dependent on tryptophan concentrations.

1985 • 56 citations

Role of L3T4-bearing T-cell populations in experimental murine chlamydial salpingitis

1991 • 54 citations

Mycobacterial growth and sensitivity to H2O2 killing in human monocytes in vitro

1997 • 49 citations

Pathogenesis of Chlamydial Infections

1989 • 46 citations

Neither Interleukin-6 nor Inducible Nitric Oxide Synthase Is Required for Clearance ofChlamydia trachomatisfrom the Murine Genital Tract Epithelium

1998 • 45 citations

Gamma interferon levels during Chlamydia trachomatis pneumonia in mice

1993 • 38 citations

Failure to detect cell-mediated cytotoxicity against Chlamydia trachomatis-infected cells

1983 • 38 citations

Resistance to macrophage-mediated killing as a factor influencing the pathogenesis of chronic cutaneous leishmaniasis.

1983 • 37 citations

Expression of Functional ICAM-1 and VCAM-1 Adhesion Molecules by an Immortalized Epithelial Cell Clone Derived from the Small Intestine

1997 • 33 citations

Characterization of gamma interferon-mediated cytotoxicity to chlamydia-infected fibroblasts

1989 • 24 citations

Ultrastructural analysis of the anti-chlamydial activity of recombinant murine interferon-γ

1987 • 23 citations

Immunoassay for detecting Chlamydia trachomatis major outer membrane protein

1983 • 17 citations