Cross-Referencing Eukaryotic Genomes: TIGR Orthologous Gene Alignments (TOGA)

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Gene Ontology: tool for the unification of biology

2000 • 38,297 citations

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGG: Kyoto Encyclopedia of Genes and Genomes

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Initial sequencing and analysis of the human genome

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The Sequence of the Human Genome

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Basic Local Alignment Search Tool

1990 • 12,947 citations

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

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WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

The Genome Sequence of Drosophila melanogaster

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CAP3: A DNA Sequence Assembly Program

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Life with 6000 Genes

1996 • 4,125 citations

The COG database: a tool for genome-scale analysis of protein functions and evolution

2000 • 4,098 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

A Genomic Perspective on Protein Families

1997 • 3,531 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Comparative Genomics of the Eukaryotes

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Regulation of the G2/M transition by p53

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Distinguishing Homologous from Analogous Proteins

1970 • 1,512 citations

The Pezcoller lecture: cancer cell cycles revisited.

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The Rb/E2F pathway: expanding roles and emerging paradigms

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Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

p53

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Phylogenomics: Improving Functional Predictions for Uncharacterized Genes by Evolutionary Analysis

1998 • 632 citations

Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems

1999 • 562 citations

Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery

1998 • 557 citations

The TIGR Gene Indices: analysis of gene transcript sequences in highly sampled eukaryotic species

2001 • 463 citations

Evolutionary parameters of the transcribed mammalian genome: An analysis of 2,820 orthologous rodent and human sequences

1998 • 456 citations

Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

2000 • 406 citations

Analysis of expressed sequence tags indicates 35,000 human genes

2000 • 367 citations

Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms

2001 • 333 citations

Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence

2000 • 324 citations

Gene Index analysis of the human genome estimates approximately 120,000 genes

2000 • 282 citations

Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs

1997 • 237 citations

A Tool for Analyzing and Annotating Genomic Sequences

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Quality Control Mechanisms During Translation

1999 • 217 citations

An Assessment of Gene Prediction Accuracy in Large DNA Sequences

2000 • 217 citations

Molecular chaperones: biology and prospects for pharmacological intervention.

1998 • 199 citations

A Survey of Human Disease Gene Counterparts in the Drosophila Genome

2000 • 198 citations

An optimized protocol for analysis of EST sequences

2000 • 146 citations

Orthologs, paralogs and genome comparisons

1999 • 136 citations

Characterization of two distinct DP‐related genes from Arabidopsis thaliana¹

2000 • 90 citations

14-3-3 Proteins: Hot numbers in signal transduction

1995 • 82 citations

Proteins Shared by the Transcription and Translation Machines

2000 • 63 citations

Retinoblastoma-related proteins in plants: homologues or orthologues of their metazoan counterparts?

2000 • 59 citations

Protein Kinase-Mediated Signaling Networks: Regulation and Functional Characterization

2003 • 3 citations

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