Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

1998 • 826 citations

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1999 • 457 citations

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

1997 • 450 citations

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1990 • 423 citations

Stimulation of P‐glycoprotein‐mediated drug transport by prazosin and progesterone

1999 • 299 citations

Systemic Antifungal Agents

1998 • 284 citations

P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.

1999 • 250 citations

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1997 • 240 citations

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1999 • 236 citations

Clinically Significant Drug Interactions with Cyclosporin

1996 • 229 citations

Macrolide Antibacterials

1995 • 206 citations

Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay

1996 • 185 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

2002 • 166 citations

P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier

1998 • 103 citations

HumanMDR1and Mousemdr1aP-Glycoprotein Alter the Cellular Retention and Disposition of Erythromycin, but Not of Retinoic Acid or Benzo(a)pyrene

1998 • 94 citations

Cloning and regulation of the ratmdr2gene

1993 • 79 citations

Effects of Ketoconazole on Digoxin Absorption and Disposition in Rat

1998 • 69 citations

Circumvention of P-GP MDR as a Function of Anthracycline Lipophilicity and Charge

1997 • 68 citations

Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.

1998 • 59 citations

Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.

1993 • 59 citations

Microfluorometric Evaluation of Calcein Acetoxymethyl Ester as a Probe for P-Glycoprotein-Mediated Resistance: Effects of Cyclosporin A and Its Nonimmunosuppressive Analogue SDZ PSC 833

1994 • 57 citations

MDR1 P-glycoprotein transports endogenous opioid peptides

2001 • 55 citations

High affinity of ergopeptides for cytochromes P450 3A

1994 • 53 citations

Modulators of P-glycoprotein-associated multidrug resistance

1991 • 47 citations

Characterization of functional assays of multidrug resistance P-glycoprotein transport activity

1997 • 30 citations

Kinetic parameters for reversal of the multidrug pump as measured for drug accumulation and cell killing

1996 • 28 citations

Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells

1995 • 25 citations

Synergism between long-acting bromocryptine microcapsules and cyclosporine A in the prevention of various autoimmune diseases in rats

1996 • 13 citations

Erythromycin increases plasma concentrations of ?-dihydroergocryptine in humans

2001 • 12 citations

Identification of hepatic, non-monoamine, dihydroergocryptine binding sites with significant gender differences

1996 • 4 citations

The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.

1998 • 4 citations