Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

1994 • 3,007 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

1998 • 826 citations

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

1996 • 598 citations

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.

1990 • 487 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Human liver carbamazepine metabolism

1994 • 428 citations

First-pass metabolism of cyclosporin by the gut

1991 • 425 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

1997 • 380 citations

Interaction between grapefruit juice and midazolam in humans*

1995 • 360 citations

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

1994 • 350 citations

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice*

1995 • 349 citations

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

1994 • 348 citations

Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme

1993 • 341 citations

Cyclosporin Clinical Pharmacokinetics

1993 • 338 citations

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1992 • 337 citations

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

1996 • 280 citations

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

1995 • 275 citations

The pharmacokinetics of midazolam in man

1981 • 273 citations

Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability.

1995 • 270 citations

Verapamil

1989 • 254 citations

The Kinetics of Aflatoxin B1Oxidation by Human cDNA-Expressed and Human Liver Microsomal Cytochromes P450 1A2 and 3A4

1996 • 247 citations

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

1994 • 221 citations

Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.

1996 • 191 citations

The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism.

1996 • 173 citations

Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies.

1996 • 157 citations

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

1995 • 141 citations

Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH-Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin, and Oxygen Surrogates

1995 • 128 citations

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

1992 • 124 citations

Felodipine kinetics in healthy men

1985 • 114 citations

Detection of a CYP3A5 Allelic Variant: A Candidate for the Polymorphic Expression of the Protein?

1996 • 84 citations

cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus.

1994 • 83 citations

Human Alfentanil Metabolism by Cytochrome P450 3A3/4. An Explanation for the Interindividual Variability in Alfentanil Clearance?

1993 • 70 citations

Population pharmacokinetics of terfenadine.

1996 • 26 citations

Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability.

1996 • 24 citations

Volume 317, Number 2 (1995), in the article "Expression of Cytochrome P450-3A5 in Escherichia-Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities," by Elizabeth M. J. Gillam, Zuyu Guo, Yuane-Fang Ueng, Hiroshi Yamazaki, Ian Cock, Paul E. B. Reilly, Wage D. Hooper, and F. Peter Guengerich pp374-384

1995 • 15 citations