MDR1 P-glycoprotein transports endogenous opioid peptides

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

A potent and selective endogenous agonist for the µ-opiate receptor

1997 • 1,306 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

1997 • 449 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

Molecular biology and pharmacology of cloned opioid receptors ¹

1995 • 231 citations

Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

1996 • 108 citations

Interaction of bioactive hydrophobic peptides with the human multidrug transporter

1994 • 90 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 81 citations

Linear and cyclic peptides as substrates and modulators of P-glycoprotein: peptide binding and effects on drug transport and accumulation

1998 • 78 citations

Altered disposition and antinociception of [D-penicillamine(2,5)] enkephalin in mdr1a-gene-deficient mice.

1998 • 58 citations

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.

1992 • 49 citations