P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Recent Trends in the Discovery, Development, and Evaluation of Antifungal Agents

1987 • 477 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1992 • 335 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

Multidrug resistance and the role of P-glycoprotein knockout mice

1995 • 199 citations

A nonlinear least squares program based on differential equations, MULTI (RUNGE), for microcomputers.

1983 • 189 citations

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.

1991 • 187 citations

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method.

1997 • 176 citations

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes.

1991 • 170 citations

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

1994 • 141 citations

The Triazole Antifungal Agents: A Review of Itraconazole and Fluconazole

1990 • 129 citations

Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL

1995 • 103 citations

The pharmacokinetics of itraconazole in animals and man: an overview

1987 • 93 citations

Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein

1994 • 78 citations

Syncope and cardiac arrhythmia due to an interaction between intraconazole and terfenadine

1993 • 76 citations

The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism.

1995 • 72 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

Reversal of daunorubicin resistance in P388/ADR cells by itraconazole.

1991 • 54 citations

Terfenadine (seldane®): A new drug for restoring sensitivity to multidrug resistant cancer cells

1993 • 53 citations

Renal secretion of vinblastine, vincristine and colchicine in vivo.

1994 • 40 citations

Enhanced expression by the brain matrix of P-glycoprotein in brain capillary endothelial cells.

1994 • 35 citations

Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells

1996 • 33 citations

Performance of Bayesian feedback to forecast lidocaine serum concentration: Evaluation of the prediction error and the prediction interval

1985 • 22 citations

Itraconazole and multidrug resistance: Possible effects on remission rate and disease-free survival in acute leukemia

1993 • 21 citations

Effect of itraconazole on the pharmacokinetics of digoxin in guinea pigs

1999 • 18 citations

Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats

1996 • 8 citations