AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

2012 • 3,329 citations

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

2005 • 2,774 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

2005 • 1,901 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

2003 • 1,604 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

2005 • 1,518 citations

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

2004 • 1,311 citations

Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

2005 • 1,302 citations

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

Hypothalamic mTOR Signaling Regulates Food Intake

2006 • 1,217 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

2003 • 1,123 citations

Expression of ghrelin receptor mRNA in the rat and the mouse brain

2005 • 1,029 citations

The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

2005 • 986 citations

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

2002 • 969 citations

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

2005 • 945 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Lipotoxic Diseases

2002 • 835 citations

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

2002 • 829 citations

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

2004 • 745 citations

Regulation of Fasted Blood Glucose by Resistin

2004 • 720 citations

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

2004 • 713 citations

Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance

2005 • 669 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

2003 • 580 citations

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

2005 • 542 citations

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

2003 • 523 citations

Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

2004 • 508 citations

Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase

2005 • 473 citations

Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats

2001 • 469 citations

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

2003 • 371 citations

Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status

2004 • 323 citations

Role of resistin in diet-induced hepatic insulin resistance

2004 • 322 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Role of resistin in diet-induced hepatic insulin resistance

2004 • 305 citations

Convergence of Pre- and Postsynaptic Influences on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus

2001 • 303 citations

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

2004 • 299 citations

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

2004 • 297 citations

Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells

2002 • 292 citations

Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle

2006 • 279 citations

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

2006 • 276 citations

Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

2003 • 273 citations

Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth

2001 • 271 citations

mTOR integrates amino acid- and energy-sensing pathways

2003 • 268 citations

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

2004 • 253 citations

Components of a Calmodulin-dependent Protein Kinase Cascade

1998 • 249 citations

Rapid transformation of white adipocytes into fat-oxidizing machines

2004 • 231 citations

Molecular disruption of hypothalamic nutrient sensing induces obesity

2006 • 231 citations

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

2005 • 214 citations

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

1999 • 211 citations

Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue

2005 • 172 citations

Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice

2004 • 148 citations

Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus

2004 • 147 citations

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition

2004 • 145 citations

Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats

2005 • 139 citations

High-fat diet feeding impairs both the expression and activity of AMPKa in rats’ skeletal muscle

2005 • 135 citations

Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase

2004 • 131 citations

Regulation of mTOR by amino acids and resistance exercise in skeletal muscle

2005 • 129 citations

Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice

2005 • 124 citations

Function of Mammalian LKB1 and Ca2+/Calmodulin-dependent Protein Kinase Kinase α as Snf1-activating Kinases in Yeast

2005 • 114 citations

The activation of p38 MAPK by the β‐adrenergic agonist isoproterenol in rat epididymal fat cells

1998 • 111 citations

Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin

2005 • 109 citations

β-Adrenoceptors, but not α-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1

2005 • 100 citations

Endurance training increases skeletal muscle LKB1 and PGC-1α protein abundance: effects of time and intensity

2005 • 99 citations

Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle

2005 • 99 citations

Endocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts

2002 • 89 citations

Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside

2004 • 75 citations

AMP-Activated Protein Kinase Is Activated by the Stimulations of Gq-Coupled Receptors

2000 • 68 citations

Possible involvement of AMP‐activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat

2004 • 66 citations

Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification

2005 • 56 citations

Distinct immunohistochemical localization of two isoforms of Ca²⁺/calmodulin‐dependent protein kinase kinases in the adult rat brain

2000 • 56 citations

Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle

2004 • 30 citations

Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKβ) and characterization of CaMKKβ and CaMKKα distribution in the adult mouse brain

2003 • 24 citations