Glucagon Represses Signaling through the Mammalian Target of Rapamycin in Rat Liver by Activating AMP-activated Protein Kinase

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

2003 • 1,604 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Translational control of gene expression

2000 • 1,371 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Translational control of gene expression

2001 • 1,192 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Management of cellular energy by the AMP‐activated protein kinase system

2003 • 851 citations

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

2002 • 829 citations

Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

2000 • 783 citations

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

2004 • 737 citations

S6K1^−/−/S6K2^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

2004 • 726 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

Synthesis of the translational apparatus is regulated at the translational level

2000 • 515 citations

Rheb fills a GAP between TSC and TOR

2003 • 467 citations

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

2004 • 455 citations

Specific features of glycogen metabolism in the liver

1998 • 394 citations

Expression cloning and signaling properties of the rat glucagon receptor

1993 • 393 citations

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

2003 • 380 citations

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

2003 • 371 citations

Tuberous Sclerosis: from Tubers to mTOR

2003 • 337 citations

Modulation of the Helicase Activity of eIF4A by eIF4B, eIF4H, and eIF4F

2001 • 334 citations

Biochemical and Kinetic Characterization of the RNA Helicase Activity of Eukaryotic Initiation Factor 4A

1999 • 326 citations

Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis In 3T3-L1 Adipocytes

2003 • 287 citations

Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth

2001 • 271 citations

Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients.

1995 • 237 citations

Identification and characterization of a mitogen-activated S6 kinase.

1988 • 223 citations

Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin

2003 • 215 citations

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

2000 • 210 citations

LKB1, a protein kinase regulating cell proliferation and polarity

2003 • 191 citations

Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G

1997 • 175 citations

The p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3

2003 • 165 citations

Control of p70 ribosomal protein S6 kinase and acetyl‐CoA carboxylase by AMP‐activated protein kinase and protein phosphatases in isolated hepatocytes

2002 • 162 citations

Synthesis and secretion of rat albumin in vivo, in perfused liver, and in isolated hepatocytes. Effects of hypophysectomy and growth hormone treatment.

1977 • 136 citations

LKB1 — A master tumour suppressor of the small intestine and beyond

2002 • 119 citations

Evidence for a catabolic role of glucagon during an amino acid load.

1996 • 115 citations

Effects of Glucagon on General Protein Degradation and Synthesis in Perfused Rat Liver

1974 • 111 citations

Effects of Hypophysectomy on Amino Acid Metabolism and Gluconeogenesis in the Perfused Rat Liver

1973 • 92 citations

Dissociation of double stranded polynucleotide helical structures by eukaryotic initiation factors, as revealed by a novel assay

1989 • 88 citations

Hepatic amino acid‐dependent signaling is under the control of AMP‐dependent protein kinase

2002 • 77 citations

The role of glucagon in the control of protein and amino acid metabolism in vivo

1994 • 65 citations

Glucagon Promotes cAMP-response Element-binding Protein Phosphorylation via Activation of ERK1/2 in MIN6 Cell Line and Isolated Islets of Langerhans

2004 • 62 citations

[4] The perfused rat liver

1975 • 58 citations

In Rat Hepatocytes Glucagon Increases Mammalian Target of Rapamycin Phosphorylation on Serine 2448 but Antagonizes the Phosphorylation of Its Downstream Targets Induced by Insulin and Amino Acids

2004 • 52 citations

Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase

2001 • 51 citations

Inhibition of rat hepatocyte proliferation by transforming growth factor ? and glucagon is associated with inhibition of ERK2 and p70 S6 kinase

1999 • 47 citations

TSC1 and TSC2: genes that are mutated in the human genetic disorder tuberous sclerosis

2003 • 37 citations