Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

2003 • 1,604 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

2004 • 1,311 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

1995 • 1,163 citations

The AMP-activated protein kinase pathway – new players upstream and downstream

2004 • 1,129 citations

The AMP-activated protein kinase cascade – a unifying system for energy control

2003 • 1,115 citations

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

1997 • 1,025 citations

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

1999 • 1,009 citations

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

2001 • 935 citations

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

1995 • 896 citations

Management of cellular energy by the AMP‐activated protein kinase system

2003 • 851 citations

Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

1998 • 749 citations

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

2004 • 699 citations

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

2003 • 580 citations

Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

2004 • 546 citations

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

2003 • 491 citations

MO25 / interact with STRAD / enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

2003 • 422 citations

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

2003 • 372 citations

Exercise Induces Isoform-Specific Increase in 5′AMP-Activated Protein Kinase Activity in Human Skeletal Muscle

2000 • 350 citations

Essential role of PDK1 in regulating cell size and development in mice

2002 • 322 citations

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

2004 • 299 citations

Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

2003 • 273 citations

Invited Review: Intracellular signaling in contracting skeletal muscle

2002 • 268 citations

Location and function of three sites phosphorylated on rat acetyl‐CoA carboxylase by the AMP‐activated protein kinase

1990 • 262 citations

Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis

2003 • 233 citations

Contraction Regulation of Akt in Rat Skeletal Muscle

2002 • 199 citations

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

2003 • 192 citations

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

2002 • 184 citations

Analysis of the LKB1-STRAD-MO25 complex

2004 • 160 citations

Identification of the sucrose non‐fermenting related kinase SNRK, as a novel LKB1 substrate

2005 • 158 citations

Yeast Pak1 Kinase Associates with and Activates Snf1

2003 • 147 citations

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

2002 • 128 citations

Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart

2005 • 107 citations

Myocardial Ischemia Differentially Regulates LKB1 and an Alternate 5′-AMP-activated Protein Kinase Kinase

2004 • 106 citations

IGF-1 phosphorylates AMPK-α subunit in ATM-dependent and LKB1-independent manner

2004 • 95 citations

5??? Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise

2004 • 79 citations